WO2003087357A3 - Nucleic acid comprising retinal-specific regulatory region - Google Patents

Nucleic acid comprising retinal-specific regulatory region Download PDF

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Publication number
WO2003087357A3
WO2003087357A3 PCT/IB2003/002015 IB0302015W WO03087357A3 WO 2003087357 A3 WO2003087357 A3 WO 2003087357A3 IB 0302015 W IB0302015 W IB 0302015W WO 03087357 A3 WO03087357 A3 WO 03087357A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
retinal
regulatory region
specific regulatory
expression
Prior art date
Application number
PCT/IB2003/002015
Other languages
French (fr)
Other versions
WO2003087357A2 (en
Inventor
Felix Loosli
Jochen Wittbrodt
Original Assignee
European Molecular Biology Lab Embl
Felix Loosli
Jochen Wittbrodt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by European Molecular Biology Lab Embl, Felix Loosli, Jochen Wittbrodt filed Critical European Molecular Biology Lab Embl
Priority to AU2003230125A priority Critical patent/AU2003230125A1/en
Publication of WO2003087357A2 publication Critical patent/WO2003087357A2/en
Publication of WO2003087357A3 publication Critical patent/WO2003087357A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to nucleic acid molecules that regulate the expression of heterologous nucleic acid sequences to which they are transcriptionally linked. In particular, the invention relates to a nucleic acid molecule that promotes the expression of a heterologous nucleic acid sequence in retinal cells. Methods of tracking retinal development and of isolating retinal progenitor cells are also provided.
PCT/IB2003/002015 2002-04-17 2003-04-17 Nucleic acid comprising retinal-specific regulatory region WO2003087357A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003230125A AU2003230125A1 (en) 2002-04-17 2003-04-17 Nucleic acid comprising retinal-specific regulatory region

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0208818.5 2002-04-17
GBGB0208818.5A GB0208818D0 (en) 2002-04-17 2002-04-17 Nucleic acid molecule

Publications (2)

Publication Number Publication Date
WO2003087357A2 WO2003087357A2 (en) 2003-10-23
WO2003087357A3 true WO2003087357A3 (en) 2004-01-29

Family

ID=9935022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/002015 WO2003087357A2 (en) 2002-04-17 2003-04-17 Nucleic acid comprising retinal-specific regulatory region

Country Status (3)

Country Link
AU (1) AU2003230125A1 (en)
GB (1) GB0208818D0 (en)
WO (1) WO2003087357A2 (en)

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 17 September 2001 (2001-09-17), LOOSLI F: "Oryzias latipes mRNA for Rx3 protein", XP002261123, Database accession no. AJ298300 *
DATABASE EMBL [online] 3 July 1997 (1997-07-03), MATHERS PH ET AL: "Xenopus laevis retinal homeobox 1A (Rx1A) mRNA, complete cds.", XP002261148, Database accession no. AF001048 *
EL-HODIRI H M ET AL: "Characterization of the Xenopus laevis Rx1A promoter in transgenic frogs", IOVS, vol. 42, no. 4, 15 March 2001 (2001-03-15), Annual Meeting of the Association for Research in Vision and Ophthalmology;Fort Lauderdale, Florida, USA; April 29-May 04, 2001, pages S657, XP001153230 *
HIRSCH NICOLAS ET AL: "Xenopus tropicalis transgenic lines and their use in the study of embryonic induction.", DEVELOPMENTAL DYNAMICS, vol. 225, no. 4, December 2002 (2002-12-01), pages 522 - 535, XP009020621, ISSN: 1058-8388 (ISSN print) *
LOOSLI FELIX ET AL: "Medaka eyeless is the key factor linking retinal determination and eye growth", DEVELOPMENT (CAMBRIDGE), vol. 128, no. 20, AJ298300, October 2001 (2001-10-01), pages 4035 - 4044, XP002261080, ISSN: 0950-1991 *
MATHERS P H ET AL: "Regulation of eye formation by the Rx and pax6 homeobox genes", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 57, no. 2, February 2000 (2000-02-01), pages 186 - 194, XP002261082, ISSN: 1420-682X *
MATHERS P H ET AL: "The Rx homeobox gene is essential for vertebrate eye development", NATURE (LONDON), vol. 387, no. 6633, AF001048, 1997, pages 603 - 607, XP001156120, ISSN: 0028-0836 *
SHASTRY BARKUR S: "Hereditary degenerative retinopathies: Optimism for somatic gene therapy", IUBMB LIFE, vol. 49, no. 6, June 2000 (2000-06-01), pages 479 - 484, XP009020622, ISSN: 1521-6543 *
ZHANG LI ET AL: "Targeted expression of the dominant-negative FGFR4a in the eye using Xrx1A regulatory sequences interferes with normal retinal development.", DEVELOPMENT (CAMBRIDGE), vol. 130, no. 17, September 2003 (2003-09-01), pages 4177 - 4186, XP009020655, ISSN: 0950-1991 *

Also Published As

Publication number Publication date
AU2003230125A8 (en) 2003-10-27
WO2003087357A2 (en) 2003-10-23
GB0208818D0 (en) 2002-05-29
AU2003230125A1 (en) 2003-10-27

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