WO2003087124A3 - Peptides hmgn2 et molecules associees a ecotaxie selective vers des vaisseaux sanguins tumoraux et cellules tumorales - Google Patents

Peptides hmgn2 et molecules associees a ecotaxie selective vers des vaisseaux sanguins tumoraux et cellules tumorales Download PDF

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Publication number
WO2003087124A3
WO2003087124A3 PCT/US2003/010240 US0310240W WO03087124A3 WO 2003087124 A3 WO2003087124 A3 WO 2003087124A3 US 0310240 W US0310240 W US 0310240W WO 03087124 A3 WO03087124 A3 WO 03087124A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood vessels
tumor
tumor cells
melecules
hmgn2
Prior art date
Application number
PCT/US2003/010240
Other languages
English (en)
Other versions
WO2003087124A2 (fr
Inventor
Erkki Ruoslahti
Kimmo Porkka
Sven Christian
Original Assignee
Burnham Inst
Erkki Ruoslahti
Kimmo Porkka
Sven Christian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/400,083 external-priority patent/US7544767B2/en
Application filed by Burnham Inst, Erkki Ruoslahti, Kimmo Porkka, Sven Christian filed Critical Burnham Inst
Priority to AU2003228431A priority Critical patent/AU2003228431A1/en
Publication of WO2003087124A2 publication Critical patent/WO2003087124A2/fr
Publication of WO2003087124A3 publication Critical patent/WO2003087124A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention a trait à un conjugué comprenant une groupe fonctionnel thérapeutique lié à un molécule à écotaxie se dirigeant de manière sélective vers des vaisseaux sanguins tumoraux et des cellules tumorales et se liant de manière spécifique au récepteur lié par le peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). L'invention a trait également à des procédés d'orientation d'un conjugué de l'invention vers des vaisseaux sanguins tumoraux et des cellules tumorales et d'utilisation d'un conjugué pour le traitement du cancer.
PCT/US2003/010240 2002-04-05 2003-04-02 Peptides hmgn2 et molecules associees a ecotaxie selective vers des vaisseaux sanguins tumoraux et cellules tumorales WO2003087124A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003228431A AU2003228431A1 (en) 2002-04-05 2003-04-02 Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11686602A 2002-04-05 2002-04-05
US10/116,866 2002-04-05
US10/400,083 2003-03-20
US10/400,083 US7544767B2 (en) 2002-04-05 2003-03-20 HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells

Publications (2)

Publication Number Publication Date
WO2003087124A2 WO2003087124A2 (fr) 2003-10-23
WO2003087124A3 true WO2003087124A3 (fr) 2006-08-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/010240 WO2003087124A2 (fr) 2002-04-05 2003-04-02 Peptides hmgn2 et molecules associees a ecotaxie selective vers des vaisseaux sanguins tumoraux et cellules tumorales

Country Status (2)

Country Link
AU (1) AU2003228431A1 (fr)
WO (1) WO2003087124A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7357928B2 (en) 2002-04-08 2008-04-15 University Of Louisville Research Foundation, Inc. Method for the diagnosis and prognosis of malignant diseases
US7541150B2 (en) 2002-04-08 2009-06-02 University Of Louisville Research Foundation, Inc Method for the diagnosis and prognosis of malignant diseases
CN1862258B (zh) * 2005-05-12 2012-05-30 清华大学 核仁素辅助的癌症诊断与治疗方法
US8231895B2 (en) 2008-05-22 2012-07-31 Universidade De Coimbra Targeted delivery to human diseases and disorders
US9260517B2 (en) 2009-11-17 2016-02-16 Musc Foundation For Research Development Human monoclonal antibodies to human nucleolin
WO2011119058A2 (fr) 2010-03-22 2011-09-29 Universidade De Coimbra Nanoparticules lipidiques vectorisées par le peptide f3, utiles pour le traitement de maladies liées à une angiogenèse
EP2555802A1 (fr) * 2010-04-08 2013-02-13 Sanford-Burnham Medical Research Institute Méthodes et compositions pour une administration améliorée de composés
ES2690557T3 (es) 2011-06-02 2018-11-21 University Of Louisville Research Foundation, Inc. Nanopartículas conjugadas a un agente antinucleolina
WO2016127346A1 (fr) * 2015-02-11 2016-08-18 四川大学华西医院 Variant du ligand induisant l'apoptose associé au facteur de nécrose tumorale, son procédé de préparation et son utilisation
WO2016172515A1 (fr) 2015-04-23 2016-10-27 Sanford Burnham Prebys Medical Discovery Institute Système d'administration ciblée et procédés d'utilisation correspondants
WO2016179394A1 (fr) 2015-05-05 2016-11-10 Malik Mohammad Tariq Nanoparticules conjuguées à un agent antinucléoline en tant que radiosensibiliseurs et agents de contraste d'imagerie par résonance magnétique (irm) et/ou en rayons x

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468758B1 (en) * 1998-09-23 2002-10-22 Corixa Corporation Compositions and methods for ovarian cancer therapy and diagnosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468758B1 (en) * 1998-09-23 2002-10-22 Corixa Corporation Compositions and methods for ovarian cancer therapy and diagnosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PORKKA ET AL: "A Fragment of the HMGN2 Protein Homes to the Nuclei of Tumor Cells and Tumor Endothelial Cells In Vivo", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 11, May 2002 (2002-05-01), pages 7444 - 7449, XP002904203 *
WALKER R. ET AL.: "The Partial Amino Acid Sequence of a Non-Histone Chromosomal Protein", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 73, no. 1, November 1976 (1976-11-01), pages 72 - 78, XP024845966, DOI: doi:10.1016/0006-291X(76)90498-8 *

Also Published As

Publication number Publication date
AU2003228431A8 (en) 2003-10-27
AU2003228431A1 (en) 2003-10-27
WO2003087124A2 (fr) 2003-10-23

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