WO2003087087A3 - Heterocyclic compounds and their use as modulators of p38 map kinase - Google Patents
Heterocyclic compounds and their use as modulators of p38 map kinase Download PDFInfo
- Publication number
- WO2003087087A3 WO2003087087A3 PCT/GB2003/001507 GB0301507W WO03087087A3 WO 2003087087 A3 WO2003087087 A3 WO 2003087087A3 GB 0301507 W GB0301507 W GB 0301507W WO 03087087 A3 WO03087087 A3 WO 03087087A3
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- WIPO (PCT)
- Prior art keywords
- group
- hydrogen
- hydrocarbyl
- halogen
- map kinase
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/06—Antibacterial agents for tuberculosis
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003584043A JP2005526831A (en) | 2002-04-09 | 2003-04-08 | Pharmaceutical compounds |
EP03720680A EP1495016A2 (en) | 2002-04-09 | 2003-04-08 | Heterocyclic compounds and their use as modulators of p38 map kinase |
AU2003224257A AU2003224257A1 (en) | 2002-04-09 | 2003-04-08 | Heterocyclic compounds and their use as modulators of p38 map kinase |
US10/962,085 US20050124620A1 (en) | 2002-04-09 | 2004-10-08 | Pharmaceutical compounds |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0208248.5 | 2002-04-09 | ||
GB0208248A GB0208248D0 (en) | 2002-04-09 | 2002-04-09 | Pharmaceutical compounds |
GB0215180.1 | 2002-06-29 | ||
GB0215180A GB0215180D0 (en) | 2002-06-29 | 2002-06-29 | Pharmaceutical compounds |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/962,085 Continuation US20050124620A1 (en) | 2002-04-09 | 2004-10-08 | Pharmaceutical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003087087A2 WO2003087087A2 (en) | 2003-10-23 |
WO2003087087A3 true WO2003087087A3 (en) | 2003-12-18 |
Family
ID=29252442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/001507 WO2003087087A2 (en) | 2002-04-09 | 2003-04-08 | Heterocyclic compounds and their use as modulators of p38 map kinase |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1495016A2 (en) |
JP (1) | JP2005526831A (en) |
AU (1) | AU2003224257A1 (en) |
WO (1) | WO2003087087A2 (en) |
Cited By (6)
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US8865735B2 (en) | 2011-02-21 | 2014-10-21 | Hoffman-La Roche Inc. | Solid forms of a pharmaceutically active substance |
US9096593B2 (en) | 2009-11-06 | 2015-08-04 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
US9169250B2 (en) | 2006-11-22 | 2015-10-27 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
US9447089B2 (en) | 2009-04-03 | 2016-09-20 | Plexxikon Inc. | Compositions and uses thereof |
US9469640B2 (en) | 2007-07-17 | 2016-10-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
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US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
JP4399253B2 (en) | 2001-06-20 | 2010-01-13 | ワイス | Substituted indoleic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
JP2006505571A (en) * | 2002-10-15 | 2006-02-16 | リゲル ファーマシューテイカルズ、インコーポレイテッド | Substituted indoles and their use as HCV inhibitors |
WO2004052855A2 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
DK1569901T3 (en) | 2002-12-10 | 2009-02-16 | Wyeth Corp | Aryl, aryloxy and alkoxy-substituted 1H-indol-3-yl-glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
CA2509222A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
MXPA05012377A (en) | 2003-05-15 | 2006-05-25 | Arqule Inc | Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38. |
US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
PT1753764E (en) | 2004-06-09 | 2009-01-28 | Glaxo Group Ltd | Pyrrolopyridine derivatives |
AR050253A1 (en) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | COMPOSITE DERIVED FROM INDAZOL CARBOXAMIDE, COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT |
US7829560B2 (en) | 2004-07-08 | 2010-11-09 | Arqule, Inc. | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase |
CA2576297C (en) | 2004-08-12 | 2011-01-25 | Pfizer Inc. | Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors |
WO2006023865A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
EP1809636A1 (en) | 2004-10-19 | 2007-07-25 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase |
JP2008526988A (en) * | 2005-01-14 | 2008-07-24 | シージーアイ ファーマシューティカルズ,インコーポレーテッド | 1,3-Diaryl-substituted ureas as kinase activity modulators |
CA2603457A1 (en) * | 2005-04-07 | 2006-10-19 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
CA2618513A1 (en) * | 2005-08-11 | 2007-02-22 | Ariad Pharmaceuticals, Inc. | Unsaturated heterocyclic derivatives |
JP2009504762A (en) | 2005-08-17 | 2009-02-05 | ワイス | Substituted indoles and methods for their use |
ES2301380B1 (en) | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | NEW DERIVATIVES OF 1,7-NAFTIRIDINE. |
WO2008029168A2 (en) * | 2006-09-08 | 2008-03-13 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
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EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
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US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
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Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2695290A (en) * | 1952-03-28 | 1954-11-23 | Hoffmann La Roche | Derivatives of indole and method for the production thereof |
GB842996A (en) * | 1956-06-22 | 1960-08-04 | Irwin Neisler & Co | Pyridine derivatives |
US3300506A (en) * | 1959-10-16 | 1967-01-24 | Neisler Lab Inc | 1-indolyl substituted-2-pyridyl-ethanes |
US4496572A (en) * | 1981-08-26 | 1985-01-29 | Pfizer Inc. | Benzo-fused thromboxane synthetase inhibitors |
EP0471296A1 (en) * | 1990-08-13 | 1992-02-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs |
JPH0543544A (en) * | 1991-08-09 | 1993-02-23 | Nisshin Flour Milling Co Ltd | Indole derivative and anticancer agent resistance overcomer containing the same as active ingredient |
WO1993018026A1 (en) * | 1992-03-04 | 1993-09-16 | Beecham Group Plc | Indole ureas as 5-ht1c receptor antogonists |
EP0733628A1 (en) * | 1995-03-20 | 1996-09-25 | Eli Lilly And Company | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists |
WO1996039382A1 (en) * | 1995-06-06 | 1996-12-12 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives as 5-ht antagonists |
WO1999043654A2 (en) * | 1998-02-25 | 1999-09-02 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
US6069156A (en) * | 1995-04-10 | 2000-05-30 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as cGMP-PDE inhibitors |
WO2000046198A1 (en) * | 1999-02-05 | 2000-08-10 | Astrazeneca Ab | Anti-inflammatory indole derivatives |
WO2001047922A2 (en) * | 1999-12-24 | 2001-07-05 | Aventis Pharma Limited | Azaindoles |
-
2003
- 2003-04-08 WO PCT/GB2003/001507 patent/WO2003087087A2/en not_active Application Discontinuation
- 2003-04-08 AU AU2003224257A patent/AU2003224257A1/en not_active Abandoned
- 2003-04-08 JP JP2003584043A patent/JP2005526831A/en active Pending
- 2003-04-08 EP EP03720680A patent/EP1495016A2/en not_active Withdrawn
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2695290A (en) * | 1952-03-28 | 1954-11-23 | Hoffmann La Roche | Derivatives of indole and method for the production thereof |
GB842996A (en) * | 1956-06-22 | 1960-08-04 | Irwin Neisler & Co | Pyridine derivatives |
US3300506A (en) * | 1959-10-16 | 1967-01-24 | Neisler Lab Inc | 1-indolyl substituted-2-pyridyl-ethanes |
US4496572A (en) * | 1981-08-26 | 1985-01-29 | Pfizer Inc. | Benzo-fused thromboxane synthetase inhibitors |
EP0471296A1 (en) * | 1990-08-13 | 1992-02-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs |
JPH0543544A (en) * | 1991-08-09 | 1993-02-23 | Nisshin Flour Milling Co Ltd | Indole derivative and anticancer agent resistance overcomer containing the same as active ingredient |
WO1993018026A1 (en) * | 1992-03-04 | 1993-09-16 | Beecham Group Plc | Indole ureas as 5-ht1c receptor antogonists |
EP0733628A1 (en) * | 1995-03-20 | 1996-09-25 | Eli Lilly And Company | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists |
US6069156A (en) * | 1995-04-10 | 2000-05-30 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as cGMP-PDE inhibitors |
WO1996039382A1 (en) * | 1995-06-06 | 1996-12-12 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives as 5-ht antagonists |
WO1999043654A2 (en) * | 1998-02-25 | 1999-09-02 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
WO2000046198A1 (en) * | 1999-02-05 | 2000-08-10 | Astrazeneca Ab | Anti-inflammatory indole derivatives |
WO2001047922A2 (en) * | 1999-12-24 | 2001-07-05 | Aventis Pharma Limited | Azaindoles |
Non-Patent Citations (7)
Title |
---|
BIOCHEM. PHARMACOL., vol. 51, no. 2, 1996, US, pages 159 - 63 * |
CHEMICAL ABSTRACTS, vol. 119, no. 27, 1993, Columbus, Ohio, US; abstract no. 180651v, page 773; XP002257894 * |
CHEMICAL ABSTRACTS, vol. 124, no. 11, 1996, Columbus, Ohio, US; abstract no. 135662s, JOHN F. REINHARD JR.: "EFFECTS OF 540C91{E-3}[2-(4'-PYRIDYL)-VINYL]-INDOLE" page 148; column 1; XP002257895 * |
CHEMICAL ABSTRACTS, vol. 53, no. 11, 1959, Columbus, Ohio, US; abstract no. 9462i, J.H. MIRSKY: "CNS DEPRESSANT OF SOME INDOLYL-ETHYLPYRIDINES." page 9462; XP002257897 * |
CHEMICAL ABSTRACTS, vol. 70, no. 27, 1969, Columbus, Ohio, US; abstract no. 19857b, A.K.SHEINKMAN: "SYNTHESIS A. PHARMACOLOGY OF N-(PYRIDYLALKYL)-INDOLINES AND INDOLES." page 1973; column 2; XP002257896 * |
J. PHARMACOL. EXPTL. THERAP., vol. 125, 1959, pages 122 - 7 * |
KHIM.-FARM. ZH., vol. 2, no. 9, 1968, USSR, pages 29 - 35 * |
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US9487515B2 (en) | 2006-11-22 | 2016-11-08 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
US9469640B2 (en) | 2007-07-17 | 2016-10-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US9447089B2 (en) | 2009-04-03 | 2016-09-20 | Plexxikon Inc. | Compositions and uses thereof |
US9096593B2 (en) | 2009-11-06 | 2015-08-04 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US8865735B2 (en) | 2011-02-21 | 2014-10-21 | Hoffman-La Roche Inc. | Solid forms of a pharmaceutically active substance |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
Also Published As
Publication number | Publication date |
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AU2003224257A8 (en) | 2003-10-27 |
AU2003224257A1 (en) | 2003-10-27 |
JP2005526831A (en) | 2005-09-08 |
EP1495016A2 (en) | 2005-01-12 |
WO2003087087A2 (en) | 2003-10-23 |
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