WO2003086512A1 - Dispositif d'administration d'un produit injectable - Google Patents

Dispositif d'administration d'un produit injectable Download PDF

Info

Publication number
WO2003086512A1
WO2003086512A1 PCT/CH2003/000239 CH0300239W WO03086512A1 WO 2003086512 A1 WO2003086512 A1 WO 2003086512A1 CH 0300239 W CH0300239 W CH 0300239W WO 03086512 A1 WO03086512 A1 WO 03086512A1
Authority
WO
WIPO (PCT)
Prior art keywords
drive member
feed direction
metering
displacement
product
Prior art date
Application number
PCT/CH2003/000239
Other languages
German (de)
English (en)
Inventor
Fritz Kirchhofer
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Priority to EP03709542A priority Critical patent/EP1558307A1/fr
Priority to AU2003213971A priority patent/AU2003213971A1/en
Publication of WO2003086512A1 publication Critical patent/WO2003086512A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A61M2005/31506—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit formed as a single piece, e.g. moulded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps

Definitions

  • the invention relates to a device for administering an injectable product according to the preamble of claim 1.
  • An injection device as the invention also relates, is known from WO 00/41753.
  • the injection device comprises a housing, a product reservoir with a piston displaceably accommodated therein, the displacement of which displaces product from the reservoir, a drive device and a metering device.
  • the drive device comprises a drive member which is displaceable in the feed device and an output member which is prevented from moving against the feed direction, but is moved by the drive member when the drive member is displaced in the feed direction and thereby pushes the piston in the feed direction, so that Product is displaced from the reservoir.
  • the pourable product dose is set by means of a metering device.
  • the dosing device comprises the drive member and the dosing member for setting the distal end position of the drive member.
  • the dosing member is rotatably mounted in the housing about the displacement axis of the drive member. It preferably has a metering stop that rotates spirally about this axis of displacement, preferably with a continuous course with a constant slope relative to the axis of displacement of the drive member, against which the drive member strikes during a displacement into the distal position, ie the angular position of the metering member determines the distal position of the drive member ,
  • the pourable product dose is preferably selected by rotating the metering element in discrete steps.
  • the dosing element locks in the rotational angle locking positions formed regularly between the housing and the dosing element. A rotation of the dosing member between two adjacent locking positions corresponds to an adjustable, smallest product dose.
  • FR-A-2 701 211 discloses an injection device for administering an injectable product, with a rear housing sleeve, in the interior of which a longitudinally displaceable output member is provided, which acts on the piston of a product reservoir arranged in the front housing sleeve.
  • the drive member is displaced in the feed direction and the driven member, which is round in cross section and provided with circumferential recesses, is also moved by locking means.
  • the drive element also serves for metering.
  • longitudinal slots of different lengths are provided in the peripheral wall of the rear housing half, into which a cam attached to the drive member engages. To adjust the dose, the cam must be pressed in and the feed sleeve turned.
  • DE 195 49 676 discloses an injection device with a housing for receiving a product reservoir for the product to be injected and an output member in the form of a polygonal toothed rack which can be displaced axially by means of a drive member, the toothed rack having at least two axially offset rows of teeth which interact with the drive member via locking means , Due to the axial displacement of the teeth, at least one locking means is not in engagement with the driven member.
  • Newer injection devices in particular those which are disposed of as a whole after administration of the last product dose, are made entirely of plastic.
  • An embodiment of the output element in the form of a toothed rack or a rod provided with recesses is subject to technical limits insofar as the spacing of the teeth of a row of teeth or recesses cannot be arbitrarily reduced due to injection molding problems.
  • significantly higher production costs arise because the output element cannot be continuously machined, but rather individual ones Teeth or recesses must be planed or ground to the exact position.
  • Checking the exactness of the arrangement and the presence of equally spaced teeth of a row of teeth or recesses and in particular of axially offset rows of teeth is very complex and requires visual checks of each individual rack. With larger quantities, this is very time and cost intensive.
  • the invention has set itself the task of creating an output member for one of the aforementioned devices for administering an injectable product, which enables simple checking of product errors or the functional accuracy of such devices.
  • the output member is designed in the form of a threaded rod and the locking means / drivers are designed in accordance with the thread pitch.
  • Such a configuration allows the mechanical checking of the exactness of the thread pitch of the output member, locking means and driver by means of a thread gauge.
  • a continuous channel in the corresponding molded part ensures that a continuous thread is arranged on the output member due to the flow behavior of plastic.
  • the metering member is preferably mounted rotatably and axially displaceably in the housing about the displacement axis of the drive member, while the input and output members are not rotatably mounted in the housing.
  • Fig. 1 shows an injection device with a metering device in a longitudinal section
  • Fig. 2 shows a metering member with a projecting drive member and corresponding locking means
  • Fig. 3 shows an output member according to the invention
  • the injection device has a housing with a front housing sleeve 1 and a rear housing sleeve 10 firmly connected to it.
  • the front housing sleeve serves as a receptacle for an ampoule 2.
  • the ampoule 2 contains a liquid product in the form of an active ingredient solution, for example insulin.
  • a piston 3 is accommodated in the ampoule 2.
  • the product By moving the piston 3 in the feed direction towards an ampoule outlet 4, the product is displaced from the ampoule 2 through its outlet 4 and poured out through an injection needle N.
  • the front housing sleeve 1 is protected by a cap K.
  • the needle N is protected again by a needle cap.
  • the displacement of the piston 3 in the feed direction is brought about by a drive device which is accommodated in the rear housing sleeve 10.
  • the Antriebsein direction comprises as a driven member, a threaded rod 5, which acts directly on the piston 3, and a drive member 6.
  • the drive member 6 is mounted in the rear housing sleeve 10 in and against the direction of advance of the piston 3 along a displacement axis V straight.
  • a metering element designed as a sleeve body is secured against displacement with the rear housing sleeve 10, but is rotatably connected about the common longitudinal axis, which coincides with the displacement axis V.
  • the dosing member 15 projects with a front sleeve part 17 into the rear housing sleeve 10. Its rear sleeve part protrudes from the rear housing sleeve 10.
  • the rear sleeve part of the metering element 15 is provided with a profiling 16 in order to be able to manually rotate the metering element 15 in a hand-safe manner.
  • the metering member 15 In front of the profiling 16, the metering member 15 carries a clearly visible dose scale all around its outer circumferential surface, which is matched to fixed rotational angle positions in which the metering member 15 is locked against the rear housing sleeve 10.
  • the locking mechanism between the metering member 15 and the rear housing sleeve 10 is raised by 21 on the outer jacket of the front sleeve part 17 of the metering member 15 and depressions in the inner jacket of the rear housing sleeve 10 are formed.
  • the depressions are circumferentially arranged at the same height next to one another at the same height on the inner casing of the rear housing sleeve 10.
  • the plurality of elevations 21 In the fixed rotational angle locking positions of the metering element 15, the plurality of elevations 21 are received exactly in the respectively opposite recesses in the inner casing of the rear housing sleeve 10.
  • the metering member 15 is penetrated by the drive member 6.
  • the dosing member 15 concentrically surrounds a distal part of the drive member 6 and also of the driven member 5.
  • the cover 9 projects with a sleeve part into an annular gap formed between the drive member 6 and the metering member 15.
  • the cover 9 also carries a marking in its jacket region protruding from the dosing member 15, which in cooperation with the marking of the dosing member 15 enables the exact determination of the total amount of product administered from the ampoule 2 even after several full rotations of the dosing member 15.
  • the maximum dose path length that can be covered in the feed direction by the drive member 6 and the rack 5 is set, and thus also the maximum product dose that can be dispensed during an injection.
  • the front sleeve part 17 of the dosing member 15 is formed spirally on its front, proximal end face 18, i.e. the front sleeve part 17 progressively drops in a circumferential direction with respect to the displacement axis V of the drive member 6 from a foremost end portion.
  • the metering takes place in a foremost, proximal end position of the drive member 6 in relation to the feed direction, in which a stop cam or collar 13 protruding radially from the outer lateral surface of the drive member 6 bears against a stop formed by the rear housing sleeve 10.
  • the metering member 15 is rotated about the displacement axis V relative to the rear housing sleeve 10 until it has reached the desired dosing or angular position.
  • a clear metering distance remains between a further collar or cam, which also projects from the outer circumferential surface of the drive member 6 and forms a metering stop and is therefore referred to in the further metering cam 14, and the proximal end face 18 of the metering member 15 opposite this metering cam 14 ,
  • the drive member 6 can be retracted relative to the rear housing sleeve 10 and thus also relative to the piston 3 against the feed direction.
  • the withdrawal is carried out manually by pulling on the lid 9.
  • the dosing distance is equal to the dose path length in the subsequent administration.
  • the locking means 11 and 12 are locking cams, each on one of the front
  • End of an elastically resilient tongue are formed and radially inward from its tongue, corresponding to the slope of the threaded rod 5, on the
  • Threaded rod 5 to protrude.
  • the locking means 11 and 12 cooperate with the thread of the threaded rod 5 facing them, in such a way that they have a
  • At least one to four or more locking means (11, 12) should be designed for safe use.
  • FIG. 2. 2 shows the drive member 6 immediately before reaching its distal end position, ie the stop position on the dosing member 15.
  • the two dosing stops interacting for this purpose namely the proximal, spirally rotating end face 18 of the dosing member 15 and the metering cams 14 projecting transversely from the drive member 6 have the same constant slope ⁇ relative to the displacement axis V. For the spiral metering stop 18, this results in the recognizable, continuous course with the constant slope ⁇ .
  • a single edge 19 extends parallel to the displacement axis V and connects the proximal tip of the dosing stop 18 to its distal base.
  • the proximal end face 18 of the metering element 15 does not have any further edges.
  • the metering stop 14 formed by the metering cam 14 is adapted, at least on its surface opposite the spiral metering stop 18, to that of the spiral metering stop 18 such that the metering cam 14 in the arrangement shown in FIG. 2 consists of the drive and metering member on the metering stop 18 with a 360 ° rotation as can be pushed along on an inclined plane.
  • the dosing steps of the injection device are defined exclusively by the locking mechanism between the rear housing sleeve 10 and the dosing member 15.
  • the metering cam 14 of the drive member 6 forming the metering stop 14 can be designed independently of the fineness of the metering steps in an optimal manner with regard to its mechanical strength.
  • the metering stop 14 extends on the outer jacket of the drive member 6 over an angle which is approximately five times as large as the angular distance between two immediately successive rotational angular locking positions of the metering member 15.
  • the threaded rod is formed by a rod with a round cross-section, the outer surface of which is provided with a single-thread or multi-thread (Fig. 3).
  • the threaded rod has a distal area 51, the outer surface of which is not provided with threads. This area 51 serves to guide the driven member 5 in the drive member 6.
  • vertical longitudinal grooves 8, 8 ′ are provided on the threaded rod 5, which engage in corresponding counter elements (not shown) of the drive member 6 in order to twist the threaded rod 5 relative to the drive member 6 to prevent.
  • the threaded rod 5 can have at least one longitudinal groove 8 or, for example, four longitudinal grooves 8, 8 ', which the Divide the threaded rod into four 90 ° thread segments.
  • the longitudinal grooves 8, 8 ′ run along the entire threaded part of the threaded rod 5 and end in the distal region 51.
  • the displacement of the threaded rod 5 in the feed direction is effected by the drive member 6.
  • the drive member 6 runs in the feed direction in four tongues, which have radially inwardly projecting locking cams at their front ends.
  • Three drivers 7a-c designed in this way are shown in FIG. 2. At least one to four or more drivers should be designed for safe use.
  • the locking means 11, 12 mentioned above and the catches 7a-c shown in FIG. 2 are identical in form and mode of operation in the exemplary embodiment. Both are formed by latching cams on resilient tongues.
  • the slope of the locking cams as best seen on the locking cam 7b in Fig. 2 corresponds to the thread pitch of the threaded rod.
  • the needle N is preferably a 31 G or 32 G needle.

Abstract

L'invention concerne un dispositif pour l'administration dosée d'un produit injectable. Ce dispositif comprend un corps (1, 10), pourvu d'un réservoir (2) destiné au produit, un piston (3), qui, lors d'un déplacement dans un sens d'avancement, refoule du produit contenu dans ce réservoir (2) vers un orifice de sortie (4) de ce dernier, un élément d'entraînement (6), pouvant être déplacé dans le sens d'avancement jusqu'à une position finale proximale et en sens inverse jusqu'à une position finale distale le long d'un axe de déplacement (V), un élément mené (5), bloqué contre tout glissement inverse au sens d'avancement et entraîné par l'élément d'entraînement (6) lors d'un déplacement de cet élément d'entraînement (6) dans le sens d'avancement, de manière à pousser le piston (3) dans le sens d'avancement, ledit élément mené (5) étant conçu sous forme de tige filetée à section transversale circulaire.
PCT/CH2003/000239 2002-04-17 2003-04-11 Dispositif d'administration d'un produit injectable WO2003086512A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03709542A EP1558307A1 (fr) 2002-04-17 2003-04-11 Dispositif d'administration d'un produit injectable
AU2003213971A AU2003213971A1 (en) 2002-04-17 2003-04-11 Device for administering an injectable product

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH6382002 2002-04-17
CH638/02 2002-04-17

Publications (1)

Publication Number Publication Date
WO2003086512A1 true WO2003086512A1 (fr) 2003-10-23

Family

ID=29220547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2003/000239 WO2003086512A1 (fr) 2002-04-17 2003-04-11 Dispositif d'administration d'un produit injectable

Country Status (3)

Country Link
EP (1) EP1558307A1 (fr)
AU (1) AU2003213971A1 (fr)
WO (1) WO2003086512A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046770A1 (fr) * 2003-11-03 2005-05-26 Haselmeier S.A.R.L. Appareil d'injection
WO2006114010A1 (fr) * 2005-04-25 2006-11-02 Tecpharma Licensing Ag Compensation de longueur pour un dispositif de reglage d'un dispositif d'injection
US7291132B2 (en) 2003-08-12 2007-11-06 Eli Lilly And Company Medication dispensing apparatus with triple screw threads for mechanical advantage
WO2014096396A1 (fr) * 2012-12-21 2014-06-26 Novo Nordisk A/S Appareil de modification de l'état d'un système d'administration de médicaments

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB622848A (en) * 1947-01-16 1949-05-09 Duncan Menzies Mclintock Improvements in hypodermic syringes
FR2701211A1 (fr) 1993-02-08 1994-08-12 Aguettant Lab Instrument doseur, notamment d'injection.
WO2000023133A2 (fr) * 1998-10-21 2000-04-27 Medico Development Investment Company Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede
WO2000041753A1 (fr) 1999-01-12 2000-07-20 Disetronic Licensing Ag Dispositif d'administration d'un produit injectable
US6228067B1 (en) * 1997-03-03 2001-05-08 B D MEDICO S.à.R.L. Injection device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB622848A (en) * 1947-01-16 1949-05-09 Duncan Menzies Mclintock Improvements in hypodermic syringes
FR2701211A1 (fr) 1993-02-08 1994-08-12 Aguettant Lab Instrument doseur, notamment d'injection.
US5807346A (en) * 1993-02-08 1998-09-15 Laboratoire Aguettant Metering instrument, particularly for injecting medicinal liquid
US6228067B1 (en) * 1997-03-03 2001-05-08 B D MEDICO S.à.R.L. Injection device
WO2000023133A2 (fr) * 1998-10-21 2000-04-27 Medico Development Investment Company Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede
WO2000041753A1 (fr) 1999-01-12 2000-07-20 Disetronic Licensing Ag Dispositif d'administration d'un produit injectable

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291132B2 (en) 2003-08-12 2007-11-06 Eli Lilly And Company Medication dispensing apparatus with triple screw threads for mechanical advantage
US7427275B2 (en) 2003-08-12 2008-09-23 Eli Lilly And Company Medication dispensing apparatus with triple screw threads for mechanical advantage
WO2005046770A1 (fr) * 2003-11-03 2005-05-26 Haselmeier S.A.R.L. Appareil d'injection
US8747367B2 (en) 2003-11-03 2014-06-10 Haselmeier Gmbh Injection device
WO2006114010A1 (fr) * 2005-04-25 2006-11-02 Tecpharma Licensing Ag Compensation de longueur pour un dispositif de reglage d'un dispositif d'injection
AU2006239705B2 (en) * 2005-04-25 2009-07-02 Tecpharma Licensing Ag Longitudinal compensation for an adjusting device of an injection device
WO2014096396A1 (fr) * 2012-12-21 2014-06-26 Novo Nordisk A/S Appareil de modification de l'état d'un système d'administration de médicaments
CN105025960A (zh) * 2012-12-21 2015-11-04 诺和诺德股份有限公司 用于药物传输装置的状态改变器械
US10117996B2 (en) 2012-12-21 2018-11-06 Novo Nordisk A/S State changing appliance for a drug delivery device

Also Published As

Publication number Publication date
EP1558307A1 (fr) 2005-08-03
AU2003213971A1 (en) 2003-10-27

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