WO2003086453A8 - Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis - Google Patents

Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis

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Publication number
WO2003086453A8
WO2003086453A8 PCT/IT2002/000231 IT0200231W WO03086453A8 WO 2003086453 A8 WO2003086453 A8 WO 2003086453A8 IT 0200231 W IT0200231 W IT 0200231W WO 03086453 A8 WO03086453 A8 WO 03086453A8
Authority
WO
WIPO (PCT)
Prior art keywords
neuroaminidase
antigen
recombinant
positiveness
genomic sequence
Prior art date
Application number
PCT/IT2002/000231
Other languages
French (fr)
Other versions
WO2003086453A9 (en
WO2003086453A1 (en
Inventor
Ilaria Capua
Stefano Marangon
Giovanni Cattoli
Original Assignee
Ilaria Capua
Stefano Marangon
Giovanni Cattoli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ilaria Capua, Stefano Marangon, Giovanni Cattoli filed Critical Ilaria Capua
Priority to AU2002253542A priority Critical patent/AU2002253542B2/en
Priority to EP02722692A priority patent/EP1494708A1/en
Priority to EP07015810A priority patent/EP1980268A2/en
Priority to PCT/IT2002/000231 priority patent/WO2003086453A1/en
Priority to CA002482244A priority patent/CA2482244A1/en
Priority to JP2003583471A priority patent/JP2005538343A/en
Priority to US10/511,229 priority patent/US20060121447A1/en
Priority to IT000306A priority patent/ITPD20020306A1/en
Publication of WO2003086453A1 publication Critical patent/WO2003086453A1/en
Publication of WO2003086453A8 publication Critical patent/WO2003086453A8/en
Publication of WO2003086453A9 publication Critical patent/WO2003086453A9/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)

Abstract

Within the prophylaxis strategies for the control of type A avian influenza caused by viral infection with specific epidemic strain H7N1, a vaccination process is envisaged comprising the preparation of a heterologous vaccine that is administered to an animal population, said vaccine featuring the same subtype of viral haemoagglutinin HA7 and a different subtype of neuroaminidase NA3, and thereafter detecting the viralinfection positiveness by contacting an antigen with at least one genomic sequence that codes for a neuroaminidase NA1 protein with the biological fluids collected from the animals. By subsequently revealing an antigen-antibody reaction by means of a test for detecting positiveness (iIFA, ELISA among others), the vaccinated animals can be discriminated from the other ones. The recombinant antigen is represented by the recombinant glycoprotein neuroaminidase NA1, the genomic sequence of which is carried by a baculovirus and expressed in insect cell.
PCT/IT2002/000231 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis WO2003086453A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2002253542A AU2002253542B2 (en) 2002-04-12 2002-04-12 Purified subfragment encoding neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
EP02722692A EP1494708A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
EP07015810A EP1980268A2 (en) 2002-04-12 2002-04-12 Vaccination methods against avian influenza virus
PCT/IT2002/000231 WO2003086453A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
CA002482244A CA2482244A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
JP2003583471A JP2005538343A (en) 2002-04-12 2002-04-12 Purified subfragment encoding neuraminidase, recombinant neuraminidase, and its use in animal prevention
US10/511,229 US20060121447A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
IT000306A ITPD20020306A1 (en) 2002-04-12 2002-12-03 PURIFIED CODING SUBFRAGMENT FOR NEURAMINIDASE, RECOMBINANT NEURAMINIDASE AND THEIR USE IN ZOOPROPHYLAXIS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2002/000231 WO2003086453A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis

Publications (3)

Publication Number Publication Date
WO2003086453A1 WO2003086453A1 (en) 2003-10-23
WO2003086453A8 true WO2003086453A8 (en) 2004-12-29
WO2003086453A9 WO2003086453A9 (en) 2005-04-14

Family

ID=29227537

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2002/000231 WO2003086453A1 (en) 2002-04-12 2002-04-12 Purified subfragment codifying for neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis

Country Status (7)

Country Link
US (1) US20060121447A1 (en)
EP (2) EP1494708A1 (en)
JP (1) JP2005538343A (en)
AU (1) AU2002253542B2 (en)
CA (1) CA2482244A1 (en)
IT (1) ITPD20020306A1 (en)
WO (1) WO2003086453A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2573007A1 (en) * 2004-07-02 2006-03-30 Henry L. Niman Copy choice recombination and uses thereof
TWI365074B (en) * 2004-10-07 2012-06-01 Wyeth Corp Multivalent avian influenza vaccines
CN103451158B (en) * 2005-04-21 2018-11-23 佛罗里达大学研究基金公司 The substance and method controlled for respiratory disease in canid
US11865172B2 (en) 2005-04-21 2024-01-09 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
US7959929B2 (en) 2005-04-21 2011-06-14 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
US9072701B2 (en) 2006-04-21 2015-07-07 St. Jude Children's Research Hospital Avian influenza viruses, vaccines, compositions, formulations, and methods
CL2008000747A1 (en) * 2007-03-16 2008-04-25 Wyeth Corp VACCINE COMPOSITION THAT INCLUDES A FIRST AND A SECOND INACTIVATED VIRUS OF THE AVIAN INFLUENZA VIRUS; METHOD FOR VACCINATING A BIRD.
JP5182753B2 (en) * 2008-09-01 2013-04-17 富士フイルム株式会社 How to predict the risk of influenza
CN107746869A (en) * 2009-12-28 2018-03-02 赛诺菲疫苗技术公司 The production of heterologous polypeptide in microalgae, the extracellular body of microalgae, composition and its production and use
JP6623534B2 (en) * 2015-03-27 2019-12-25 東ソー株式会社 Binding factor for influenza virus RNA detection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751225B1 (en) * 1996-07-19 1998-11-27 Rhone Merieux AVIAN POLYNUCLEOTIDE VACCINE FORMULA

Also Published As

Publication number Publication date
CA2482244A1 (en) 2003-10-23
WO2003086453A9 (en) 2005-04-14
EP1494708A1 (en) 2005-01-12
JP2005538343A (en) 2005-12-15
ITPD20020306A1 (en) 2003-10-13
WO2003086453A1 (en) 2003-10-23
US20060121447A1 (en) 2006-06-08
AU2002253542A1 (en) 2003-10-27
AU2002253542B2 (en) 2007-06-07
EP1980268A2 (en) 2008-10-15

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