WO2003084980A3 - Peptide amphiphile solutions and self assembled peptide nanofiber networks - Google Patents

Peptide amphiphile solutions and self assembled peptide nanofiber networks Download PDF

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Publication number
WO2003084980A3
WO2003084980A3 PCT/US2003/010051 US0310051W WO03084980A3 WO 2003084980 A3 WO2003084980 A3 WO 2003084980A3 US 0310051 W US0310051 W US 0310051W WO 03084980 A3 WO03084980 A3 WO 03084980A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
cells
self
peptide amphiphile
nanofiber networks
Prior art date
Application number
PCT/US2003/010051
Other languages
French (fr)
Other versions
WO2003084980A2 (en
Inventor
Samuel I Stupp
Jeffrey D Hartgerink
Elia Beniash
Original Assignee
Univ Northwestern
Samuel I Stupp
Jeffrey D Hartgerink
Elia Beniash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern, Samuel I Stupp, Jeffrey D Hartgerink, Elia Beniash filed Critical Univ Northwestern
Priority to AU2003222167A priority Critical patent/AU2003222167A1/en
Publication of WO2003084980A2 publication Critical patent/WO2003084980A2/en
Publication of WO2003084980A3 publication Critical patent/WO2003084980A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Peptide amphiphile self assembly and gelation to form nanofiber networks having cells within the network are described. The molecular structure of peptide amphiphiles and compositions including them suitable for forming nanofiber networks with cells under physiological conditions are also described. Methods to incorporate dissociated cells into self-assembled peptide amphiphile gels for molding of implants, in situ molding in animals, and injection of peptide amphiphile and cell compositions into an animal for tissue engineering and tissue repair applications are disclosed. The methods and compositions of the present invention are used to grow animal cells in a self assembled nanofiber network.
PCT/US2003/010051 2002-04-02 2003-04-02 Peptide amphiphile solutions and self assembled peptide nanofiber networks WO2003084980A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003222167A AU2003222167A1 (en) 2002-04-02 2003-04-02 Peptide amphiphile solutions and self assembled peptide nanofiber networks

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36963802P 2002-04-02 2002-04-02
US60/369,638 2002-04-02

Publications (2)

Publication Number Publication Date
WO2003084980A2 WO2003084980A2 (en) 2003-10-16
WO2003084980A3 true WO2003084980A3 (en) 2003-12-11

Family

ID=28791973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/010051 WO2003084980A2 (en) 2002-04-02 2003-04-02 Peptide amphiphile solutions and self assembled peptide nanofiber networks

Country Status (2)

Country Link
AU (1) AU2003222167A1 (en)
WO (1) WO2003084980A2 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002365162A1 (en) 2001-11-14 2003-07-09 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
KR20050100397A (en) 2003-02-11 2005-10-18 노오쓰웨스턴 유니버시티 Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US7704740B2 (en) 2003-11-05 2010-04-27 Michigan State University Nanofibrillar structure and applications including cell and tissue culture
WO2005056576A2 (en) 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
EP1696945B1 (en) 2003-12-05 2012-01-18 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
EP3031466B1 (en) * 2004-07-06 2018-11-28 3D Matrix, Inc. Purified amphiphilic peptide compositions and uses thereof
NZ555294A (en) 2005-01-21 2010-07-30 Univ Northwestern Methods and amphiphilic compositions for treating damaged nerve cells
MX2007010771A (en) 2005-03-04 2008-03-10 Univ Northwestern Angiogenic heparin binding peptide amphiphiles.
US9162005B2 (en) 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
KR20100102750A (en) 2005-04-25 2010-09-24 메사추세츠 인스티튜트 오브 테크놀로지 Compositions and methods for promoting hemostasis and other physiological activities
ES2673947T3 (en) * 2006-04-25 2018-06-26 Massachusetts Institute Of Technology Compositions and methods to affect the movement of pollutants, body fluids or other entities and / or affect other physiological conditions
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
EP2146733B1 (en) 2007-03-14 2020-11-25 Arch Biosurgery, Inc. Treatment of leaky or damaged tight junctions and enhancing extracellular matrix
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
GB0807102D0 (en) * 2008-04-18 2008-05-21 Ici Plc Process and composition
WO2010019651A1 (en) * 2008-08-13 2010-02-18 Dow Global Technologies Inc. Peptide-coated fibers
WO2010041636A1 (en) 2008-10-06 2010-04-15 株式会社スリー・ディー・マトリックス Tissue plug
WO2010120830A1 (en) 2009-04-13 2010-10-21 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
WO2011072482A1 (en) 2009-12-14 2011-06-23 The University Of Hong Kong Nano cancer barrier device(ncbd) to immobilize and inhibit the division of metastic cancer stem cells
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
EP3466964A1 (en) 2012-07-06 2019-04-10 3-D Matrix Ltd. Fill-finish process for peptide solutions
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
JP6502352B2 (en) 2013-08-22 2019-04-17 アーチ・バイオサージェリー・インコーポレイテッド Implantable mesh for controlling fluid movement
WO2015138514A1 (en) 2014-03-10 2015-09-17 3-D Matrix, Ltd. Self-assembling peptide compositions
WO2015136370A2 (en) 2014-03-10 2015-09-17 3-D Matrix, Ltd. Sterilization and filtration of peptide compositions
US10245299B2 (en) 2014-03-10 2019-04-02 3-D Matrix, Ltd. Autoassembling peptides for the treatment of pulmonary bulla
DE102015000363A1 (en) 2015-01-20 2016-07-21 Emc Microcollections Gmbh New modular functionalizable peptide hydrogels
EP3362079B1 (en) 2015-10-14 2022-04-06 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
US10814038B2 (en) 2016-01-06 2020-10-27 3-D Matrix, Ltd. Combination compositions
US11324703B2 (en) 2017-12-15 2022-05-10 3-D Matrix, Ltd. Surfactant peptide nanostructures and uses thereof in drug delivery
GB201908522D0 (en) * 2019-06-13 2019-07-31 Univ Newcastle Supramolecular structures

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH0399096A (en) * 1989-09-11 1991-04-24 Agency Of Ind Science & Technol Length control of short fiber-type helical molecule associated form
WO1997014713A1 (en) * 1995-10-17 1997-04-24 Coletica Amphiphilic complexes, method for preparing same and compositions containing such complexes
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0399096A (en) * 1989-09-11 1991-04-24 Agency Of Ind Science & Technol Length control of short fiber-type helical molecule associated form
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
WO1997014713A1 (en) * 1995-10-17 1997-04-24 Coletica Amphiphilic complexes, method for preparing same and compositions containing such complexes
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HARTGERINK ET AL.: "Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 8, 16 April 2002 (2002-04-16), pages 5133 - 5138, XP002972643 *
HARTGERINK ET AL.: "Self-assembly and mineralization of peptide-amphiphile nanofibers", SCIENCE, vol. 294, 23 November 2001 (2001-11-23), pages 1684 - 1688, XP002972644 *
SHIMIZU ET AL.: "Self-assembling properties of synthetic peptidic lipids", BIOCHIM. BIOPHYS. ACTA, vol. 1147, 1993, pages 50 - 58, XP002092500 *
YU ET AL.: "Self-assembling amphiphiles for construction of protein molecular architecture", J. AM. CHEM. SOC., vol. 118, 1996, pages 12515 - 12520, XP002972642 *

Also Published As

Publication number Publication date
AU2003222167A1 (en) 2003-10-20
AU2003222167A8 (en) 2003-10-20
WO2003084980A2 (en) 2003-10-16

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