WO2003083437A3 - Method and apparatus for identifying molecular species on a conductive surface - Google Patents

Method and apparatus for identifying molecular species on a conductive surface Download PDF

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Publication number
WO2003083437A3
WO2003083437A3 PCT/US2003/008813 US0308813W WO03083437A3 WO 2003083437 A3 WO2003083437 A3 WO 2003083437A3 US 0308813 W US0308813 W US 0308813W WO 03083437 A3 WO03083437 A3 WO 03083437A3
Authority
WO
WIPO (PCT)
Prior art keywords
nano
probe
conductive surface
molecular species
molecules
Prior art date
Application number
PCT/US2003/008813
Other languages
French (fr)
Other versions
WO2003083437A2 (en
Inventor
Iii Louis C Brousseau
Original Assignee
Quantum Logic Devices Inc
Iii Louis C Brousseau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Logic Devices Inc, Iii Louis C Brousseau filed Critical Quantum Logic Devices Inc
Priority to AU2003215025A priority Critical patent/AU2003215025A1/en
Publication of WO2003083437A2 publication Critical patent/WO2003083437A2/en
Publication of WO2003083437A3 publication Critical patent/WO2003083437A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
    • G01Q60/10—STM [Scanning Tunnelling Microscopy] or apparatus therefor, e.g. STM probes
    • G01Q60/16—Probes, their manufacture, or their related instrumentation, e.g. holders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q70/00—General aspects of SPM probes, their manufacture or their related instrumentation, insofar as they are not specially adapted to a single SPM technique covered by group G01Q60/00
    • G01Q70/16—Probe manufacture
    • G01Q70/18—Functionalisation

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A nano-probe for performing single electron molecular orbital tunneling spectroscopy (SEMOTS) is disclosed. Unlike the conventional probes, the nano-probe is capable of obtaining highly resolved spectra of single molecule electronic structures on conductive surfaces. The increase in spectral resolution allows the unique spectrum of adsorbed molecules to be collected into a database and subsequently used to identify adsorbates on surface on unknown samples. The nano-probe can be utilized for genetic sequencing of single molecules of deoxyribose nucleic acid and other oligonucleotides based on the differences in orbital energy spectra of the nucleotide bases.
PCT/US2003/008813 2002-03-22 2003-03-21 Method and apparatus for identifying molecular species on a conductive surface WO2003083437A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003215025A AU2003215025A1 (en) 2002-03-22 2003-03-21 Method and apparatus for identifying molecular species on a conductive surface

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36684002P 2002-03-22 2002-03-22
US60/366,840 2002-03-22

Publications (2)

Publication Number Publication Date
WO2003083437A2 WO2003083437A2 (en) 2003-10-09
WO2003083437A3 true WO2003083437A3 (en) 2003-12-18

Family

ID=28675287

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008813 WO2003083437A2 (en) 2002-03-22 2003-03-21 Method and apparatus for identifying molecular species on a conductive surface

Country Status (2)

Country Link
AU (1) AU2003215025A1 (en)
WO (1) WO2003083437A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2541419C1 (en) * 2013-08-19 2015-02-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Рязанский государственный радиотехнический университет" Probe of atomic-powered microscope with nanocomposite radiating element doped by quantum points of nucleus-shell structure
CN105531379A (en) * 2013-09-13 2016-04-27 科罗拉多州立大学董事会法人团体 Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications
US10364461B2 (en) 2014-12-08 2019-07-30 The Regents Of The University Of Colorado Quantum molecular sequencing (QM-SEQ): identification of unique nanoelectronic tunneling spectroscopy fingerprints for DNA, RNA, and single nucleotide modifications
DE102015001713B4 (en) 2015-02-13 2021-08-19 Forschungszentrum Jülich GmbH Method for measuring local electric potential fields
CN112345799B (en) * 2020-11-04 2023-11-14 浙江师范大学 PH measurement method based on single-molecule electrical detection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198667A (en) * 1991-12-20 1993-03-30 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for performing scanning tunneling optical absorption spectroscopy
US5345816A (en) * 1992-12-31 1994-09-13 International Business Machine Corp. Integrated tip strain sensor for use in combination with a single axis atomic force microscope
US6252226B1 (en) * 1994-07-28 2001-06-26 General Nanotechnology, L.L.C. Nanometer scale data storage device and associated positioning system
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6296810B1 (en) * 1993-02-01 2001-10-02 Praelux Incorporated Apparatus for DNA sequencing

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198667A (en) * 1991-12-20 1993-03-30 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for performing scanning tunneling optical absorption spectroscopy
US5345816A (en) * 1992-12-31 1994-09-13 International Business Machine Corp. Integrated tip strain sensor for use in combination with a single axis atomic force microscope
US6296810B1 (en) * 1993-02-01 2001-10-02 Praelux Incorporated Apparatus for DNA sequencing
US6252226B1 (en) * 1994-07-28 2001-06-26 General Nanotechnology, L.L.C. Nanometer scale data storage device and associated positioning system
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules

Also Published As

Publication number Publication date
WO2003083437A2 (en) 2003-10-09
AU2003215025A8 (en) 2003-10-13
AU2003215025A1 (en) 2003-10-13

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