WO2003082893A3 - Theraputic methods and uses of sapogenins and their derivatives - Google Patents

Theraputic methods and uses of sapogenins and their derivatives Download PDF

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Publication number
WO2003082893A3
WO2003082893A3 PCT/GB2003/001380 GB0301380W WO03082893A3 WO 2003082893 A3 WO2003082893 A3 WO 2003082893A3 GB 0301380 W GB0301380 W GB 0301380W WO 03082893 A3 WO03082893 A3 WO 03082893A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
sapogenins
cognitive
methods
theraputic
Prior art date
Application number
PCT/GB2003/001380
Other languages
French (fr)
Other versions
WO2003082893A8 (en
WO2003082893A2 (en
Inventor
Daryl Rees
Phil Gunning
Antonia Orsi
Zongqin Xia
Yaer Hu
Original Assignee
Phytopharm Plc
Daryl Rees
Phil Gunning
Antonia Orsi
Zongqin Xia
Yaer Hu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ARP020101170A external-priority patent/AR033079A1/en
Priority to AU2003229877A priority Critical patent/AU2003229877B8/en
Priority to NZ535093A priority patent/NZ535093A/en
Priority to BR0308788-3A priority patent/BR0308788A/en
Priority to KR1020127008441A priority patent/KR20120128596A/en
Priority to EP03722713A priority patent/EP1490071B1/en
Priority to CA2477787A priority patent/CA2477787C/en
Priority to CN038071886A priority patent/CN1642558B/en
Priority to US10/507,000 priority patent/US20050130948A1/en
Priority to IL16416103A priority patent/IL164161A0/en
Application filed by Phytopharm Plc, Daryl Rees, Phil Gunning, Antonia Orsi, Zongqin Xia, Yaer Hu filed Critical Phytopharm Plc
Priority to DE60326437T priority patent/DE60326437D1/en
Priority to KR1020047014567A priority patent/KR101130212B1/en
Priority to JP2003580357A priority patent/JP4573157B2/en
Priority to MXPA04009321A priority patent/MXPA04009321A/en
Publication of WO2003082893A2 publication Critical patent/WO2003082893A2/en
Publication of WO2003082893A8 publication Critical patent/WO2003082893A8/en
Publication of WO2003082893A3 publication Critical patent/WO2003082893A3/en
Priority to NO20044468A priority patent/NO20044468L/en
Priority to HR20041009A priority patent/HRP20041009A2/en
Priority to HK04110420.5A priority patent/HK1067546A1/en
Priority to AU2008207565A priority patent/AU2008207565A1/en
Priority to US13/085,225 priority patent/US20110190249A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)

Abstract

The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.
PCT/GB2003/001380 2002-03-27 2003-03-27 Theraputic methods and uses of sapogenins and their derivatives WO2003082893A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE60326437T DE60326437D1 (en) 2002-03-27 2003-03-27 THERAPEUTIC USE OF SAPOGENINES
KR1020047014567A KR101130212B1 (en) 2002-03-27 2003-03-27 Theraputic methods and uses of SAPOGENIN and their derivatives
NZ535093A NZ535093A (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
KR1020127008441A KR20120128596A (en) 2002-03-27 2003-03-27 Theraputic methods and uses of sapogenin and their derivatives
EP03722713A EP1490071B1 (en) 2002-03-27 2003-03-27 Therapeutic uses of sapogenins
CA2477787A CA2477787C (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
CN038071886A CN1642558B (en) 2002-03-27 2003-03-27 Use of sapogenins and derivatives thereof
US10/507,000 US20050130948A1 (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
JP2003580357A JP4573157B2 (en) 2002-03-27 2003-03-27 Method of treatment and use of sapogenin and its derivatives
AU2003229877A AU2003229877B8 (en) 2002-03-27 2003-03-27 Theraputic methods and uses of sapogenins and their derivatives
MXPA04009321A MXPA04009321A (en) 2002-03-27 2003-03-27 Theraputic methods and uses of sapogenins and their derivatives.
BR0308788-3A BR0308788A (en) 2002-03-27 2003-03-27 Therapeutic processes and uses of sapogenins and their derivatives
IL16416103A IL164161A0 (en) 2002-03-27 2003-03-27 Therapeutic methods and uses of sapogenins and their derivatives
NO20044468A NO20044468L (en) 2002-03-27 2004-10-20 Use of sapogenins and hence in the manufacture of drugs
HR20041009A HRP20041009A2 (en) 2002-03-27 2004-10-27 Theraputic methods and uses of sapogenins and their derivatives
HK04110420.5A HK1067546A1 (en) 2002-03-27 2004-12-31 Therapeutic uses of sapogenins
AU2008207565A AU2008207565A1 (en) 2002-03-27 2008-08-27 Therapeutic methods and uses of sapogenins and their derivatives
US13/085,225 US20110190249A1 (en) 2002-03-27 2011-04-12 Therapeutic methods and uses of sapogenins and their derivatives

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
ARP020101170A AR033079A1 (en) 2001-03-28 2002-03-27 SAPOGENINE DERIVATIVES, SYNTHESIS AND USE, AND METHODS BASED ON USE
ARP020101170 2002-03-27
US36817802P 2002-03-28 2002-03-28
PCT/GB2002/001578 WO2002079221A2 (en) 2001-03-28 2002-03-28 Sapogenin derivatives, their synthesis and use
GBPCT/GB02/01578 2002-03-28
US60/368,178 2002-03-28

Publications (3)

Publication Number Publication Date
WO2003082893A2 WO2003082893A2 (en) 2003-10-09
WO2003082893A8 WO2003082893A8 (en) 2003-12-31
WO2003082893A3 true WO2003082893A3 (en) 2004-04-15

Family

ID=30001210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/001380 WO2003082893A2 (en) 2002-03-27 2003-03-27 Theraputic methods and uses of sapogenins and their derivatives

Country Status (10)

Country Link
KR (1) KR20100093621A (en)
CN (1) CN1642558B (en)
AT (1) ATE424211T1 (en)
IL (1) IL164161A0 (en)
NZ (2) NZ547344A (en)
PE (1) PE20040306A1 (en)
PL (1) PL213697B1 (en)
RU (1) RU2332999C2 (en)
TW (1) TWI329016B (en)
WO (1) WO2003082893A2 (en)

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GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) * 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
JP5166272B2 (en) 2005-10-28 2013-03-21 キム・スンヨウ An extract of a plant of the genus Yamaceae, and a composition for preventing or treating peripheral neuropathy containing the same
EP2389182A1 (en) 2009-01-24 2011-11-30 Phytopharm PLC Treatment of neurotrophic factor mediated disorders
US20130210786A1 (en) 2010-07-20 2013-08-15 Patrick Alexander Howson Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
CN113956315B (en) 2011-09-08 2024-08-09 萨奇治疗股份有限公司 Neuroactive steroids, compositions, and uses thereof
CU20110244A7 (en) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem SPI-ESTEROID SYSTEMS WITH NEUROACTIVE AND ANTI-INFLAMMATORY EFFECTS
WO2013149580A1 (en) * 2012-04-03 2013-10-10 Chiming Che Timosaponin compounds
EP3932932A1 (en) 2013-03-13 2022-01-05 Sage Therapeutics, Inc. Neuroactive steriods and methods of use thereof
CN103232520A (en) * 2013-05-13 2013-08-07 中国药科大学 Spirosteroid compounds and preparation method and medical application thereof
US10259840B2 (en) 2014-06-18 2019-04-16 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10696712B2 (en) 2015-07-06 2020-06-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MX2020011449A (en) 2015-07-06 2022-02-28 Sage Therapeutics Inc Oxysterols and methods of use thereof.
CA2991313C (en) 2015-07-06 2023-12-19 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
AU2017240157B2 (en) 2016-04-01 2022-10-20 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MD3481846T2 (en) 2016-07-07 2021-11-30 Sage Therapeutics Inc 11-substituted 24-hydroxysterols for use in the treatment of NMDA related conditions
CA3038900A1 (en) 2016-09-30 2018-04-05 Sage Therapeutics, Inc. C7 substituted oxysterols and methods as nmda modulators
NZ752732A (en) 2016-10-18 2024-08-30 Sage Therapeutics Inc Oxysterols and methods of use thereof
AU2017345399B2 (en) 2016-10-18 2022-02-24 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CN108264535A (en) * 2016-12-30 2018-07-10 中国科学院上海药物研究所 A kind of antidepressant compounds and its preparation method and application
RU2635485C1 (en) * 2017-03-21 2017-11-13 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Method for optic nerve atrophy treatment after craniocerebral injury
CN109988218B (en) * 2017-12-29 2022-11-25 中国科学院上海药物研究所 Sarsasapogenin derivative and preparation method and application thereof
EP3572085A1 (en) 2018-05-25 2019-11-27 Neuro-Sys Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound
CN112457362B (en) * 2019-09-06 2023-09-19 上海青东生物科技有限公司 Halogenated tetracyclic triterpene derivative and preparation and application thereof

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Also Published As

Publication number Publication date
WO2003082893A8 (en) 2003-12-31
TW200400042A (en) 2004-01-01
IL164161A0 (en) 2005-12-18
CN1642558B (en) 2012-05-30
KR20100093621A (en) 2010-08-25
NZ547344A (en) 2007-11-30
ATE424211T1 (en) 2009-03-15
TWI329016B (en) 2010-08-21
WO2003082893A2 (en) 2003-10-09
CN1642558A (en) 2005-07-20
PL213697B1 (en) 2013-04-30
PE20040306A1 (en) 2004-05-29
PL372941A1 (en) 2005-08-08
NZ547897A (en) 2008-02-29
RU2004130281A (en) 2006-01-20
RU2332999C2 (en) 2008-09-10

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