WO2003081223A3 - Sensors with variable response behavior - Google Patents

Sensors with variable response behavior Download PDF

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Publication number
WO2003081223A3
WO2003081223A3 PCT/US2002/027676 US0227676W WO03081223A3 WO 2003081223 A3 WO2003081223 A3 WO 2003081223A3 US 0227676 W US0227676 W US 0227676W WO 03081223 A3 WO03081223 A3 WO 03081223A3
Authority
WO
WIPO (PCT)
Prior art keywords
film
electrodes
chemical
pathogen
change
Prior art date
Application number
PCT/US2002/027676
Other languages
French (fr)
Other versions
WO2003081223A2 (en
Inventor
Thomas B Stanford
Ast Camille I Van
Frederick G Yamagishi
Original Assignee
Hrl Lab Llc
Thomas B Stanford
Ast Camille I Van
Frederick G Yamagishi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/028717 external-priority patent/WO2002029378A2/en
Application filed by Hrl Lab Llc, Thomas B Stanford, Ast Camille I Van, Frederick G Yamagishi filed Critical Hrl Lab Llc
Priority to AU2002367632A priority Critical patent/AU2002367632A1/en
Publication of WO2003081223A2 publication Critical patent/WO2003081223A2/en
Publication of WO2003081223A3 publication Critical patent/WO2003081223A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

A sensor and method for detecting biological and chemical agents comprising metal interdigitized electrodes coated with hybrid polymer-based conducting film and an instrument for applying electrical voltage to the electrodes and registering the change in electrical current. The hybrid film also comprises indicator biomolecules encapsulated within the film or attached to it. The bioindicator molecules preferably comprise enzyme acetylcholinesterase. When these indicator biomolecules come in a contact with a pathogen, chemical and/or morphological changes occur in the film and electrical current flowing through the electrodes is modulated. The pathogen comprise inhibitors of enzymes, preferably organophosphates, thiophosphates or phosphonates. The change in current indicates the presence of a biological and chemical agent and is registered.
PCT/US2002/027676 2001-08-29 2002-08-29 Sensors with variable response behavior WO2003081223A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002367632A AU2002367632A1 (en) 2001-08-29 2002-08-29 Sensors with variable response behavior

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31611101P 2001-08-29 2001-08-29
US60/316,111 2001-08-29
PCT/US2001/028717 WO2002029378A2 (en) 2000-10-03 2001-09-14 Sensor for chemical and biological materials
USPCT/US01/28717 2001-09-14

Publications (2)

Publication Number Publication Date
WO2003081223A2 WO2003081223A2 (en) 2003-10-02
WO2003081223A3 true WO2003081223A3 (en) 2003-12-24

Family

ID=29738603

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/027676 WO2003081223A2 (en) 2001-08-29 2002-08-29 Sensors with variable response behavior

Country Status (2)

Country Link
AU (1) AU2002367632A1 (en)
WO (1) WO2003081223A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1912062B1 (en) * 2006-10-13 2010-09-08 Sabanci Universitesi A biosensor and chemical sensor implementation using RF and microwave device, circuits and systems
DK178111B1 (en) * 2013-10-24 2015-05-26 Københavns Uni Sol-gel based matrix

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009808A2 (en) * 1987-06-05 1988-12-15 Arthur D. Little, Inc. Receptor-based biosensors
WO1998019153A1 (en) * 1996-10-26 1998-05-07 The Victoria University Of Manchester Sensor employing impedance measurements
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US5928609A (en) * 1994-09-06 1999-07-27 Bloodhound Sensors, Ltd. Odor sensor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009808A2 (en) * 1987-06-05 1988-12-15 Arthur D. Little, Inc. Receptor-based biosensors
US5928609A (en) * 1994-09-06 1999-07-27 Bloodhound Sensors, Ltd. Odor sensor
WO1998019153A1 (en) * 1996-10-26 1998-05-07 The Victoria University Of Manchester Sensor employing impedance measurements
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PANDEY P C ET AL: "Acetylthiocholine/acetylcholine and thiocholine/choline electrochemical biosensors/sensors based on an organically modified sol-gel glass enzyme reactor and graphite paste electrode", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 62, no. 2, February 2000 (2000-02-01), pages 109 - 116, XP004189245, ISSN: 0925-4005 *
YAMAGISHI F G ET AL: "CONDUCTIVE POLYMER-BASED TRANSDUCERS AS VAPOR-PHASE DETECTORS", ANTEC. CONFERENCE PROCEEDINGS, XX, XX, vol. 2, no. 1, 1998, pages 1335 - 1339, XP000892545 *

Also Published As

Publication number Publication date
WO2003081223A2 (en) 2003-10-02
AU2002367632A1 (en) 2003-10-08
AU2002367632A8 (en) 2003-10-08

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