WO2003080841A8 - Calcineurin activators - Google Patents

Calcineurin activators

Info

Publication number
WO2003080841A8
WO2003080841A8 PCT/JP2002/006063 JP0206063W WO03080841A8 WO 2003080841 A8 WO2003080841 A8 WO 2003080841A8 JP 0206063 W JP0206063 W JP 0206063W WO 03080841 A8 WO03080841 A8 WO 03080841A8
Authority
WO
WIPO (PCT)
Prior art keywords
protein
subunits
killer
calcineurin
klkp
Prior art date
Application number
PCT/JP2002/006063
Other languages
French (fr)
Japanese (ja)
Other versions
WO2003080841A1 (en
Inventor
Hiroko Kitamoto
Tokichi Miyakawa
Original Assignee
Nat Inst Of Agrobio Sciences
Hiroko Kitamoto
Tokichi Miyakawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Inst Of Agrobio Sciences, Hiroko Kitamoto, Tokichi Miyakawa filed Critical Nat Inst Of Agrobio Sciences
Priority to JP2003578567A priority Critical patent/JP4500991B2/en
Priority to CA002479908A priority patent/CA2479908A1/en
Publication of WO2003080841A1 publication Critical patent/WO2003080841A1/en
Publication of WO2003080841A8 publication Critical patent/WO2003080841A8/en
Priority to US11/441,098 priority patent/US20060241042A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Calcineurin activators containing the following protein (a) or (b) as the active ingredient and having an effect of elevating intracellular calcium ion concentration due to flow of calcium ion into eucaryotic cells. (a) A killer protein KLKP produced by a killer yeast Kluyveromyces lactis which has three subunits respectively comprising the amino acid sequences represented by SEQ ID NOS:2 to 4. (b) A protein having three subunits as in the above protein (a), wherein at least one of the subunits has an amino acid sequence suffers from deletion, substitution or addition of one or several amino acids, and having the activity of the Kluyveromyces lactis killer protein (KLKP).
PCT/JP2002/006063 2002-03-22 2002-06-18 Calcineurin activators WO2003080841A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2003578567A JP4500991B2 (en) 2002-03-22 2002-06-18 Calcineurin activator
CA002479908A CA2479908A1 (en) 2002-03-22 2002-06-18 Calcineurin activator
US11/441,098 US20060241042A1 (en) 2002-03-22 2006-05-26 Calcineurin activators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002081415 2002-03-22
JP2002-81415 2002-03-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10507683 A-371-Of-International 2002-06-18
US11/441,098 Division US20060241042A1 (en) 2002-03-22 2006-05-26 Calcineurin activators

Publications (2)

Publication Number Publication Date
WO2003080841A1 WO2003080841A1 (en) 2003-10-02
WO2003080841A8 true WO2003080841A8 (en) 2003-12-04

Family

ID=28449120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/006063 WO2003080841A1 (en) 2002-03-22 2002-06-18 Calcineurin activators

Country Status (3)

Country Link
JP (1) JP4500991B2 (en)
CA (1) CA2479908A1 (en)
WO (1) WO2003080841A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017138660A1 (en) * 2016-02-12 2017-08-17 国立大学法人 岡山大学 Immune function inspection method, cancer patient categorization method, cancer treatment efficacy prediction method, agent for increasing intracellular calcium ion concentration, agent for increasing selective function of effector memory (em) and effector (eff) in tumor tissue, and method for monitoring efficacy of cancer drug

Also Published As

Publication number Publication date
JPWO2003080841A1 (en) 2005-07-28
WO2003080841A1 (en) 2003-10-02
JP4500991B2 (en) 2010-07-14
CA2479908A1 (en) 2003-10-02

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