WO2003077984A1 - Dispositifs d'occlusion de lumieres implantables et methodes associees - Google Patents

Dispositifs d'occlusion de lumieres implantables et methodes associees Download PDF

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Publication number
WO2003077984A1
WO2003077984A1 PCT/US2003/008015 US0308015W WO03077984A1 WO 2003077984 A1 WO2003077984 A1 WO 2003077984A1 US 0308015 W US0308015 W US 0308015W WO 03077984 A1 WO03077984 A1 WO 03077984A1
Authority
WO
WIPO (PCT)
Prior art keywords
lumen
frame
configuration
flexible member
self
Prior art date
Application number
PCT/US2003/008015
Other languages
English (en)
Inventor
John A. Reggie
Joshua Makower
J. Christopher Flaherty
Original Assignee
Transvascular, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transvascular, Inc. filed Critical Transvascular, Inc.
Priority to AU2003214193A priority Critical patent/AU2003214193A1/en
Publication of WO2003077984A1 publication Critical patent/WO2003077984A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
    • A61B2017/00557—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated inflatable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes

Definitions

  • the present invention relates generally to medical devices and methods and more particularly to implantable devices for occluding the lumens of blood vessels or other luminal anatomical structures and their methods of use.
  • Implantable embolic devices are used to occlude the lumens of blood vessels or other anatomical conduits of the body. Such embolic devices have been used for a variety of therapeutic purposes. For example, certain procedures known as PICVATM and PICABTM are being developed by TransVascular, Inc. of Menlo Park, California. These procedures utilize native veins as in situ bypass conduits for diseased arteries. In such procedures, it is typically desirable to place at least one embolic blocker in the lumen of the vein into which arterial blood has been routed to in such procedures , including blocking of blood flow in veins into which arterial blood has been routed to facilitate the intended flow of arterial blood through the vein in a direction opposite normal venous flow.
  • embolic devices of the prior art may be useable to effectively block flow though some blood vessels or other body conduits, are remains a need in the art for the development of new implantable embolic devices and methods for catheter based, transluminal delivery and implantation of such devices.
  • the present invention provides an implantable embolic device for blocking the flow of body fluid through an anatomical conduit that has a wall and a lumen (e.g., blood vessel, duct, passageway, respiratory passage, bronchus, lymphatic, iatrogenically created channel or opening, shunt, etc.).
  • the implantable embolic device comprises a generally tubular, radially expandable frame member and a flexible occluder member attached to the frame member.
  • the flexible occluder member may be formed of any suitable material, such as expanded polytetrafluoroethylene (ePTFE), that is generally in the form of a tube having an open first end and a substantially closed second end.
  • ePTFE expanded polytetrafluoroethylene
  • the open first end of the flexible occluder member is affixed (or otherwise held in abutment with) to the frame member.
  • the device is initially disposed in a first radially collapsed configuration wherein it may be transluminally advanced into the lumen of the anatomical conduit in which it is to be implanted. Thereafter, the device is expandable to a second radially expanded configuration wherein it will engage the wall of the anatomical conduit such that the closed end of the flexible member will substantially block the flow of body fluid through the lumen of the anatomical conduit.
  • the frame member may be self-expanding or pressure expandable and may be formed of any suitable material, such as metal or plastic.
  • the frame is formed of a nickel titanium alloy that is superelastic at normal body temperature of 37°C.
  • the flexible occluder member may have an opening (e.g., a small hole or self-sealing opening) formed in its closed end. A catheter, guidewire or other object may be passed through such opening. Where the opening is self-sealing, the opening will resume a substantially closed configuration after such catheter guidewire or other object is removed, such that no body fluid or no more than a clinically insignificant amount of body fluid will leak though such opening. In other embodiments the opening may simply be so small in size that it the amount of body fluid that leaks through such opening is not clinically significant or does not defeat the intended embolic function of the device.
  • the flexible occluder member may cover a portion of the frame adjacent its first end while a portion of the frame adjacent its second end remains uncovered.
  • Such partially covered embodiment of the device may be implanted in the lumen of a blood vessel or other body conduit such that pressure of body fluid distal to the first end of the frame is greater than the pressure of body fluid proximal to the second end of the frame. This serves to ensure that at least the uncovered portion of the frame will remain in firm frictional engagement even if the pressure of body fluid creates some gap or space between the covered portion of the frame and the adjacent wall of the anatomical conduit. Also, in self expanding embodiments, such partial covering of the frame will allow the uncovered portion of the frame to remain expandable without being constrained or restricted by the flexible covering.
  • an embolic device of the foregoing character is mounted on a delivery catheter for catheter-based transluminal delivery and implantation of the device.
  • the delivery catheter may comprise an outer tube having a wall and a lumen and an inner tube having a wall and a lumen, with the inner tube being disposed within the lumen of the outer tube.
  • the embolic device is mounted on the outer tube while in its first radially collapsed configuration.
  • a generally cylindrical balloon or other radially expandable member may be positioned on the delivery catheter beneath the embolic device to effect radial expansion and implantation of the embolic device.
  • the embolic device may be initially loaded into the lumen of the outer tube and advanced therefrom by a pusher element or other suitable ejection apparatus.
  • the embolic device may be mounted about the exterior of the outer tube and one or more constraining members (e.g., a retractable sheath, severable skin or covering, retractable clip(s)s, etc.) will radially constrain the embolic device, holding it in its first collapsed configuration until such time as it is desired to allow the device to radially expand in situ to its second radially expanded configuration.
  • constraining members e.g., a retractable sheath, severable skin or covering, retractable clip(s)s, etc.
  • a distal portion of the delivery catheter's inner tube may initially extend through such opening.
  • a guidewire or other elongate apparatus may extend through the lumen of the inner tube to a location distal of the embolic device.
  • radiographic contrast agent, medicaments or other substances may be injected through the lumen of the inner tube.
  • the embolic device may be re-traversed subsequent to its implantation by advancing a guidewire, catheter or other elongate apparatus through the opening.
  • Figure 1 is a side view of one embodiment of an embolic device of the present invention.
  • Figures 2a-2f are a step-by-step showing of one example of a method for assembling the embolic device of Figure 1.
  • Figures 3a-3d are a step-by-step showing of one example of a method for transluminal catheter based delivery of the embolic device shown in Figure 1.
  • Figure 3d is a perspective view of the embolic device of Figure 1 implanted in the lumen of a blood vessel wherein the pressure of the blood distal to the device has created a gap between a covered portion of the device and the surrounding blood vessel wall while the uncovered portion of the device remains in abutting coaptation with the surrounding blood vessel wall.
  • FIG. 1 shows one example of an embolic device 10 of the present invention.
  • the embolic device 10 comprises a generally tubular frame member 12 and a flexible member 14 .
  • the device 10 has a proximal end PE and a distal end DE.
  • the flexible member 14 is generally in the form of a tube having an open first end 16 and a substantially closed second end 18.
  • the open first end 16 of the flexible member 14 is affixed to the frame member 12, as shown.
  • the embolic device 10 is initially disposable in a first configuration (se Figure
  • the frame member 12 may be formed of any suitable radially expandable material such as a metal or plastic.
  • the frame member 12 is formed of a stainless steal that is plastically deformable.
  • the frame member 12 comprises a plurality of zigzag rings 25 that are connected in alignment with one another by linking segments 23.
  • Each zig-zag ring 25 of the frame 12 comprises a plurality of generally straight segments 22 connected to one another at angles so as to form apices 24 and troughs 26, as shown.
  • the frame member 12 may be formed of resilient material that, when unconstrained, will self-expand from the first configuration (Figure 3a) to the second configuration ( Figure 3b).
  • Such self-expanding embodiments of the device 10 may be mounted on or in a delivery catheter that is constructed to constrain the device in its first configuration while it is being transluminally advanced into the lumen of the body conduit and to then to allow the operator to remove the constraint from the device 10, thereby allowing the device 10 to self-expand to its second configuration within the lumen of the anatomical conduit.
  • the frame member 12 may be formed of plastically deformable material may be expanded from its first configuration to its second configuration by exertion of outwardly directed radial force upon said frame member.
  • Such pressure-expandable embodiments of the device 10 may be mounted on or in a delivery catheter that is equipped with a balloon or other radially expandable member useable to exert outwardly directed radial force upon the frame member 12 causing the device 10 to expand to its second configuration within the lumen of the anatomical conduit (see Figures 3a-3b and discussion set forth herebelow).
  • the embolic device shown in the drawings includes an optional self-sealing opening 21 formed in the closed end 18 of the flexible member 14.
  • a compression band 20 is positioned about the distal end of the flexible member 14 to compress it to a closed configuration.
  • a catheter, guidewire or other elongate apparatus may be advanced through the self-sealing opening 21 during delivery of the device or afterthe device has been implanted in the lumen of a body conduit.
  • the compression band is preferably formed of elastic or superelastic material (e.g., a rubber band, elastic thread(s), superelastic NiTi alloy, etc.)
  • the compression band 20 is formed of nickel titanium alloy that is superelastic at body temperature and is generally of a zig-zag shape, as shown.
  • the compression band 20 will dilate as a catheter, guidewire or other elongate apparatus is advance though the self-sealing opening 21 , with the flexible member 14 being firmly compressed therearound so as to deter leakage.
  • the compression band 20 will resiliently and/or elastically compress the opening 21 closed such that little or no body fluid will leak through such opening 21.
  • the compression band 20 may be constructed so as not to cause complete closure of the self sealing opening 21.
  • the self-sealing opening may be replaced by a small opening that is large enough to permit passage therethrough of a guidewire, catheter or other device but yet small enough to allow leakage of only a volume of body fluid that is not sufficiently large to defeat or substantially interfere with the intended clinical function of the device.
  • Figures 2a-2e show one example of a method for assembling the embolic device 10.
  • a plurality of longitudinally oriented slits 28 are formed in one end of a tubular workpiece 14(pre) formed of flexible material such as ePTFE.
  • the formation of these slits 28 creates a plurality of strips 30 at one end of the workpiece 14(pre), each such strip 30 having a free end 32 and an attached end 34.
  • the slits 28 extend approximately one half the length of the tubular workpiece 14(pre).
  • FIGs 3a-3d show in step-by-step fashion a method for delivery and implantation of a pressure expandable embodiment of the embolic device 10.
  • the embolic device 10 is initially mounted upon a delivery catheter 40.
  • This delivery catheter 40 comprises an outer tube 42 which has a wall and a lumen extending longitudinally therethrough and an inner tube 44 which also has a wall and a lumen.
  • the inner tube 44 is disposed within the lumen of the outertube 42.
  • a generally cylindrical balloon 48 is mounted about the outer surface of a portion of the outer tube 42 and the embolic device 10 is mounted over the balloon 48 in its second radially collapsed configuration (Figure 3a).
  • a distal portion of the inner tube 44 extends beyond the distal end of the outer tube 42 and through the self-sealing opening 21.
  • a tapered region 46 may optionally be formed at the distal end of the inner tube 44 to facilitate dilation of the self-sealing opening 21 as the inner tube is advanced therethrough.
  • a guidewire GW or other apparatus may pass through the lumen of the inner tube 44 and out of its distal end.
  • radiographic contrast media or other substances may be injected through the lumen of the inner tube 44 before or after radial expansion of the embolic device 10.
  • a fluid may be placed in the lumen of the inner tube and a pressure transducer may be attached to permit monitoring or pressures within the lumen L of the anatomical conduit AC.
  • the delivery catheter 40 having the embolic device 10 mounted thereon in its collapsed configuration is advanced into the lumen L of the anatomical conduit AC in which the device is to be implanted.
  • Radiographically visible markers may be formed on the delivery catheter 40 and/or embolic device 14 to enable the operator to verify that the embolic member is at the desired position of implantation.
  • the balloon 48 is inflated so as to radially expand the embolic device, as shown in figure 3b.
  • the expanded frame 12 frictionally engages the wall of the anatomical conduit AC.
  • the balloon is then deflated and the delivery catheter 40 and any guidewire GW or other device is removed as shown in Figure 3c. This causes the self sealing opening 21 to close and the closed end 18 of the flexible member substantially occludes the lumen L of the anatomical conduit AC.
  • the pressure of body fluid within the lumen L of the anatomical conduit AC, distal to the implanted device 10, is greater than the pressure within the lumen L proximal to the implanted device.
  • This pressure differential causes the closed end 18 of the flexible member to invert into the interior of the frame 12, as shown.
  • the wall of the anatomical conduit AC distal to the device 10 may dilate due to increased pressure or for other reasons. Such dilation of the anatomical conduit wall may result in formation of a gap or space 50 between the distal portion 54 of the device 10 (which is covered by the flexible member) and the adjacent wall of the anatomical conduit.
  • any body fluid that seeps from the gap 50 past the distal portion of the device 10 will pas through the openings in the uncovered frame 12 and will not result in disruption of the contact between the proximal portion 52 of the device 10 and the surrounding anatomical conduit wall. This helps to deter any migration or movement of the implanted device 10.
  • the embolic device As will be appreciated from the above-set-forth description, the embolic device
  • the embolic device 10 of the present invention causes rapid or substantially instantaneous occlusion of the vessel lumen and does not rely on changes that must occur over time, as may be the case with other approaches like glues and implantable occlusion coils.
  • a single embolic device 10 serves to occlude a vessel lumen whereas a number of coils or multiple applications of glue could be required in some cases.
  • the over-the-wire, balloon expandable version of this device 10 does not become "free-floating" in the blood stream. The physician retains control over the device 10 either via the delivery catheter 10 or guidewire, if deployed.
  • This approach provides a high degree of control over position of the embolic device 10 and occupies only a short length of occluded vessel as opposed to certain types of occlusion coils that may create a mass several centimeters long within a blood vessel. Also, the device 10 provides permanent occlusion of the anatomical conduit and does not tend to recannalize overtime as may occur with some other occlusion techniques.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne des dispositifs d'embolisation implantables destinés à occlure des vaisseaux sanguins et d'autres conduits anatomiques et comprenant une armature radialement extensible (12) généralement tubulaire (10) ainsi qu'un élément d'occlusion souple (14) fixé à cette armature (12). L'élément d'occlusion souple (14) peut présenter une forme généralement tubulaire et comporter une extrémité fermée (18) et une extrémité ouverte (16). L'extrémité ouverte (16) est fixée à l'armature (12) et l'extrémité fermée sert à bloquer sensiblement l'écoulement de sang à travers la lumière du conduit anatomique. Dans certains modes de réalisation, une ouverture de petite taille ou auto-obturante (21) est formée dans l'extrémité fermée (18) de l'élément d'occlusion souple (14) de façon qu'un fil-guide, un cathéter (40) ou un autre dispositif puisse passer à travers cette ouverture pendant l'introduction du dispositif et/ou après l'implantation de ce dispositif.
PCT/US2003/008015 2002-03-15 2003-03-17 Dispositifs d'occlusion de lumieres implantables et methodes associees WO2003077984A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003214193A AU2003214193A1 (en) 2002-03-15 2003-03-17 Implantable lumen occluding devices and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36443902P 2002-03-15 2002-03-15
US60/364,439 2002-03-15

Publications (1)

Publication Number Publication Date
WO2003077984A1 true WO2003077984A1 (fr) 2003-09-25

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WO (1) WO2003077984A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1547545A1 (fr) * 2003-12-26 2005-06-29 Terumo Kabushiki Kaisha Dispositif de capture d'embole et arrangement pour le déployer de ce dernier
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8864790B2 (en) 2006-04-17 2014-10-21 Covidien Lp System and method for mechanically positioning intravascular implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9023094B2 (en) 2007-06-25 2015-05-05 Microvention, Inc. Self-expanding prosthesis
US9050095B2 (en) 2004-09-22 2015-06-09 Covidien Lp Medical implant
US9198665B2 (en) 2004-09-22 2015-12-01 Covidien Lp Micro-spiral implantation device
US9289215B2 (en) 2007-03-13 2016-03-22 Covidien Lp Implant including a coil and a stretch-resistant member
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9622753B2 (en) 2001-07-20 2017-04-18 Microvention, Inc. Aneurysm treatment device and method of use
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US10058330B2 (en) 2011-05-11 2018-08-28 Microvention, Inc. Device for occluding a lumen
CN112087972A (zh) * 2018-05-08 2020-12-15 W.L.戈尔及同仁股份有限公司 阻塞设备

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6364895B1 (en) * 1999-10-07 2002-04-02 Prodesco, Inc. Intraluminal filter

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6364895B1 (en) * 1999-10-07 2002-04-02 Prodesco, Inc. Intraluminal filter

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8562667B2 (en) 2001-07-20 2013-10-22 Microvention, Inc. Aneurysm treatment device and method of use
US9622753B2 (en) 2001-07-20 2017-04-18 Microvention, Inc. Aneurysm treatment device and method of use
JP2005185759A (ja) * 2003-12-26 2005-07-14 Terumo Corp 塞栓部材捕捉用具および塞栓部材捕捉用具留置用器具
EP1547545A1 (fr) * 2003-12-26 2005-06-29 Terumo Kabushiki Kaisha Dispositif de capture d'embole et arrangement pour le déployer de ce dernier
US9050095B2 (en) 2004-09-22 2015-06-09 Covidien Lp Medical implant
US9198665B2 (en) 2004-09-22 2015-12-01 Covidien Lp Micro-spiral implantation device
US8864790B2 (en) 2006-04-17 2014-10-21 Covidien Lp System and method for mechanically positioning intravascular implants
US9289215B2 (en) 2007-03-13 2016-03-22 Covidien Lp Implant including a coil and a stretch-resistant member
US9023094B2 (en) 2007-06-25 2015-05-05 Microvention, Inc. Self-expanding prosthesis
US10058330B2 (en) 2011-05-11 2018-08-28 Microvention, Inc. Device for occluding a lumen
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US10335155B2 (en) 2011-11-30 2019-07-02 Covidien Lp Positioning and detaching implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US10893868B2 (en) 2012-01-20 2021-01-19 Covidien Lp Aneurysm treatment coils
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
CN112087972A (zh) * 2018-05-08 2020-12-15 W.L.戈尔及同仁股份有限公司 阻塞设备
US11564693B2 (en) 2018-05-08 2023-01-31 W. L. Gore & Associates, Inc. Occluder devices

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