WO2003076621A3 - Vpr modulators and uses thereof - Google Patents

Vpr modulators and uses thereof Download PDF

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Publication number
WO2003076621A3
WO2003076621A3 PCT/CA2003/000325 CA0300325W WO03076621A3 WO 2003076621 A3 WO2003076621 A3 WO 2003076621A3 CA 0300325 W CA0300325 W CA 0300325W WO 03076621 A3 WO03076621 A3 WO 03076621A3
Authority
WO
WIPO (PCT)
Prior art keywords
vpr
modulators
binding
compounds
invention further
Prior art date
Application number
PCT/CA2003/000325
Other languages
French (fr)
Other versions
WO2003076621A2 (en
Inventor
Eric A Cohen
Xiao-Jian Yao
Pierre Belhumeur
Julie Lemay
Original Assignee
Univ Montreal
Eric A Cohen
Xiao-Jian Yao
Pierre Belhumeur
Julie Lemay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montreal, Eric A Cohen, Xiao-Jian Yao, Pierre Belhumeur, Julie Lemay filed Critical Univ Montreal
Priority to AU2003209879A priority Critical patent/AU2003209879A1/en
Publication of WO2003076621A2 publication Critical patent/WO2003076621A2/en
Publication of WO2003076621A3 publication Critical patent/WO2003076621A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to compunds capable of binding to and/or modulating the activity of a Vpr or functional derivative thereof. The invention further relates to methods, products and uses of these compounds for modulation of Vpr-related activity, binding and detection of Vpr, as well as for therapy, diagnosis and/or prognostication of Vpr-related disease. The invention further relates to a method of screening in yeast for the identification of such compounds.
PCT/CA2003/000325 2002-03-08 2003-03-07 Vpr modulators and uses thereof WO2003076621A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003209879A AU2003209879A1 (en) 2002-03-08 2003-03-07 Vpr modulators and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36238402P 2002-03-08 2002-03-08
US60/362,384 2002-03-08

Publications (2)

Publication Number Publication Date
WO2003076621A2 WO2003076621A2 (en) 2003-09-18
WO2003076621A3 true WO2003076621A3 (en) 2003-11-13

Family

ID=27805168

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/000325 WO2003076621A2 (en) 2002-03-08 2003-03-07 Vpr modulators and uses thereof

Country Status (2)

Country Link
AU (1) AU2003209879A1 (en)
WO (1) WO2003076621A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7803765B2 (en) 1999-05-05 2010-09-28 Phylogica Limited Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom
CA2568644C (en) * 2004-06-03 2015-11-24 Phylogica Limited Peptide modulators of cellular phenotype and bi-nucleic acid fragment library
JP2008001598A (en) * 2004-10-12 2008-01-10 Institute Of Physical & Chemical Research Medicinal composition containing apoptosis inducer
JP5576610B2 (en) 2006-02-20 2014-08-20 フィロジカ リミテッド Peptide structure library construction and screening method
CA2663545A1 (en) 2006-09-19 2008-03-27 Phylogica Limited Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof
US8822409B2 (en) 2007-06-20 2014-09-02 Phylogica Limited Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001015511A2 (en) * 1999-09-01 2001-03-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, dna and viruses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001015511A2 (en) * 1999-09-01 2001-03-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, dna and viruses

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J KULKOSKY ET AL.: "A novel VPR peptide interactor fused to integrase (IN) restores integration activity to IN-defective HIV-1 virions", VIROLOGY., vol. 255, 1999, ACADEMIC PRESS,ORLANDO., US, pages 77 - 85, XP002252227, ISSN: 0042-6822 *
M BOUHAMDAN ET AL.: "Diversity of HIV-1 VPR interactions involves usage of the WXF motif of host cell proteins", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 14, 3 April 1998 (1998-04-03), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, pages 8009 - 8016, XP002252225, ISSN: 0021-9258 *
N OKUI ET AL.: "Packageable antiviral therapeutivd against human immunodeficiency virus type I; virion targeted virus inactivation by incorporation of a single-chain antibody against viral integrase into progeny virions", HUMAN GENE THERAPY., vol. 11, 1 March 2000 (2000-03-01), XX, XX, pages 537 - 546, XP002252226, ISSN: 1043-0342 *
X YAO ET AL.: "Genetic selection of peptide inhibitors of human immunodeficiency virus type I VPR", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 277, no. 50, 13 December 2002 (2002-12-13), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, pages 48816 - 48826, XP002252228, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2003209879A8 (en) 2003-09-22
AU2003209879A1 (en) 2003-09-22
WO2003076621A2 (en) 2003-09-18

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