WO2003076463A8 - Listeria monocytogenes ctsr mutants presenting low virulence and stress-resistance - Google Patents

Listeria monocytogenes ctsr mutants presenting low virulence and stress-resistance

Info

Publication number
WO2003076463A8
WO2003076463A8 PCT/NL2003/000178 NL0300178W WO03076463A8 WO 2003076463 A8 WO2003076463 A8 WO 2003076463A8 NL 0300178 W NL0300178 W NL 0300178W WO 03076463 A8 WO03076463 A8 WO 03076463A8
Authority
WO
WIPO (PCT)
Prior art keywords
ctsr
stress
resistance
protein
altered
Prior art date
Application number
PCT/NL2003/000178
Other languages
French (fr)
Other versions
WO2003076463A3 (en
WO2003076463A2 (en
Inventor
Kimon Andreas Karatzas
Maria Henrica Jacoba Bennik
Tjakko Abee
Michiel Kleerebezem
Vos Willem Meindert De
Original Assignee
Wageningen Ct For Food Science
Kimon Andreas Karatzas
Maria Henrica Jacoba Bennik
Tjakko Abee
Michiel Kleerebezem
Vos Willem Meindert De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wageningen Ct For Food Science, Kimon Andreas Karatzas, Maria Henrica Jacoba Bennik, Tjakko Abee, Michiel Kleerebezem, Vos Willem Meindert De filed Critical Wageningen Ct For Food Science
Priority to AU2003218833A priority Critical patent/AU2003218833A1/en
Publication of WO2003076463A2 publication Critical patent/WO2003076463A2/en
Publication of WO2003076463A3 publication Critical patent/WO2003076463A3/en
Publication of WO2003076463A8 publication Critical patent/WO2003076463A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/335—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to Gram positive bacteria with increased stress tolerance, reduced virulence, and/or reduced mobility, as a result of an altered CtsR protein. The alteration of the CtsR protein in particular concerns an alteration of the conserved glycine-rich region in the CtsR protein. The invention further relates to nucleic acid encoding the altered CtsR proteins. The altered Gram positive bacteria may be used in fermentation processes and may be used as delivery vehicles for site specific delivery of therapeutic proteins such as vaccines.
PCT/NL2003/000178 2002-03-11 2003-03-11 Listeria monocytogenes ctsr mutants presenting low virulence and stress-resistance WO2003076463A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003218833A AU2003218833A1 (en) 2002-03-11 2003-03-11 Listeria monocytogenes ctsr mutants presenting low virulence and stress-resistance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02075946 2002-03-11
EP02075946.0 2002-03-11

Publications (3)

Publication Number Publication Date
WO2003076463A2 WO2003076463A2 (en) 2003-09-18
WO2003076463A3 WO2003076463A3 (en) 2003-12-11
WO2003076463A8 true WO2003076463A8 (en) 2004-10-07

Family

ID=27798858

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2003/000178 WO2003076463A2 (en) 2002-03-11 2003-03-11 Listeria monocytogenes ctsr mutants presenting low virulence and stress-resistance

Country Status (2)

Country Link
AU (1) AU2003218833A1 (en)
WO (1) WO2003076463A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1680508B1 (en) * 2003-10-28 2011-03-30 Friesland Brands B.V. Site-specific intestinal delivery and/or production of biologically active substances
EP4355762A1 (en) * 2021-06-17 2024-04-24 DSM IP Assets B.V. Improved bacillus host cell

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077335A2 (en) * 2000-04-11 2001-10-18 Institut Pasteur Listeria monocytogenes genome, polypeptides and uses

Also Published As

Publication number Publication date
WO2003076463A3 (en) 2003-12-11
AU2003218833A1 (en) 2003-09-22
AU2003218833A8 (en) 2003-09-22
WO2003076463A2 (en) 2003-09-18

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