WO2003076388A3 - Bis-aniline derivatives useful as potassium channels modulators - Google Patents

Bis-aniline derivatives useful as potassium channels modulators Download PDF

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Publication number
WO2003076388A3
WO2003076388A3 PCT/EP2003/002490 EP0302490W WO03076388A3 WO 2003076388 A3 WO2003076388 A3 WO 2003076388A3 EP 0302490 W EP0302490 W EP 0302490W WO 03076388 A3 WO03076388 A3 WO 03076388A3
Authority
WO
WIPO (PCT)
Prior art keywords
bis
potassium channels
derivatives useful
aniline derivatives
modulators
Prior art date
Application number
PCT/EP2003/002490
Other languages
French (fr)
Other versions
WO2003076388A2 (en
Inventor
Heiko Rauer
Wael Saeb
Bernd Kramer
Juergen Kraus
Claudia Klemenz
Gabriel Garcia
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Priority to AU2003218729A priority Critical patent/AU2003218729A1/en
Publication of WO2003076388A2 publication Critical patent/WO2003076388A2/en
Publication of WO2003076388A3 publication Critical patent/WO2003076388A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to compounds having the Formula (I) or a salt, or a physiologically functional derivative, or a prodrug thereof, wherein the amine substituent is in the meta or para-position to the amine moiety of the compound of Formula (I); (A) and (B) each independently represent an aromatic hydrocarbon group which optionally contains one or more heteroatoms selected from the group consisting of S, O and N, wherein the heteroatom N is optionally substituted with R5 , and/or the heteroatom S is optionally bonded to =O or (=O)2.
PCT/EP2003/002490 2002-03-12 2003-03-11 Bis-aniline derivatives useful as potassium channels modulators WO2003076388A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003218729A AU2003218729A1 (en) 2002-03-12 2003-03-11 Bis-aniline derivatives useful as potassium channels modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10210679.7 2002-03-12
DE10210679 2002-03-12

Publications (2)

Publication Number Publication Date
WO2003076388A2 WO2003076388A2 (en) 2003-09-18
WO2003076388A3 true WO2003076388A3 (en) 2004-02-05

Family

ID=27797664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002490 WO2003076388A2 (en) 2002-03-12 2003-03-11 Bis-aniline derivatives useful as potassium channels modulators

Country Status (2)

Country Link
AU (1) AU2003218729A1 (en)
WO (1) WO2003076388A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6275703B2 (en) * 2012-06-08 2018-02-07 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション FBXO3 inhibitor

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB787659A (en) * 1955-03-14 1957-12-11 Allen & Hanburys Ltd Penicillin salts of organic bases
US3764625A (en) * 1969-04-01 1973-10-09 United States Borax Chem Trifluoromethyl-1,3-phenylenediamine compounds
DD123049A1 (en) * 1975-12-23 1976-11-20
US4268603A (en) * 1978-12-07 1981-05-19 Tokyo Ohka Kogyo Kabushiki Kaisha Photoresist compositions
DD238805A1 (en) * 1985-06-27 1986-09-03 Wolfen Filmfab Veb PROCESS FOR PREPARING LAYERING COMPOSITIONS WITH PHOTOELY PROPER PROPERTIES
JP2000111480A (en) * 1998-10-06 2000-04-21 Kazuko Matsumoto New labelling reagent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB787659A (en) * 1955-03-14 1957-12-11 Allen & Hanburys Ltd Penicillin salts of organic bases
US3764625A (en) * 1969-04-01 1973-10-09 United States Borax Chem Trifluoromethyl-1,3-phenylenediamine compounds
DD123049A1 (en) * 1975-12-23 1976-11-20
US4268603A (en) * 1978-12-07 1981-05-19 Tokyo Ohka Kogyo Kabushiki Kaisha Photoresist compositions
DD238805A1 (en) * 1985-06-27 1986-09-03 Wolfen Filmfab Veb PROCESS FOR PREPARING LAYERING COMPOSITIONS WITH PHOTOELY PROPER PROPERTIES
JP2000111480A (en) * 1998-10-06 2000-04-21 Kazuko Matsumoto New labelling reagent

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ACTA POL. PHARM., vol. 36, no. 5, 1979, pages 523 - 528 *
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN., vol. 67, no. 1, 1994, JAPAN PUBLICATIONS TRADING CO. TOKYO., JP, pages 196 - 202, ISSN: 0009-2673 *
CHEMICAL ABSTRACTS, vol. 93, no. 17, 27 October 1980, Columbus, Ohio, US; abstract no. 167833f, KOZAKIEWICZ, IRENA: "Synthesis of 4-2-(2,4-dichloro-5-sulfamoylnemzamido)-ethyl benzenesulfonamide and its reactions with some amines." page 638; column 1; XP002243031 *
CHEMISCHE BERICHTE., vol. 25, 1892, WEINHEIM DE, pages 3583 *
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002243032 *
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOEDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002243033 *
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENCHAFTEN, FRANKFURT AM MAIN, DE; XP002258265 *
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002258266 *
DAVID PARKER ET AL.: "Reaction chemistry of tri-substituted mesitylene derivatives...", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2., 1997, LETCHWORTH GB, pages 1445 - 1452, XP002243030 *
HELVETICA CHIMICA ACTA., vol. 85, no. 1, January 2002 (2002-01-01), VERLAG HELVETICA CHIMICA ACTA. BASEL., CH, pages 1 - 8, ISSN: 0018-019X *
K. STURM ET AL.: "5-Sulfamoylorthanilic acids, a sulfonamide series with salidiuretic activity", JOURNAL OF MEDICINAL CHEMISTRY., vol. 26, 1983, WASHINGTON US, pages 1174 - 1187, XP002243028 *
MOL. CRYST. LIQ. CRYST. SCI. TECHNOL. SECT. A, vol. 210, 1992, pages 21 - 30 *
YAIR SPRINZAK: "Reduction and benzylation by means of benzyl alcohol.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 78, 1956, DC US, pages 3207 - 3208, XP002243029 *

Also Published As

Publication number Publication date
AU2003218729A8 (en) 2003-09-22
AU2003218729A1 (en) 2003-09-22
WO2003076388A2 (en) 2003-09-18

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