WO2003074994A3 - A method for detecting the impacts of interfering effects on experimental data - Google Patents

A method for detecting the impacts of interfering effects on experimental data Download PDF

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Publication number
WO2003074994A3
WO2003074994A3 PCT/EP2003/002206 EP0302206W WO03074994A3 WO 2003074994 A3 WO2003074994 A3 WO 2003074994A3 EP 0302206 W EP0302206 W EP 0302206W WO 03074994 A3 WO03074994 A3 WO 03074994A3
Authority
WO
WIPO (PCT)
Prior art keywords
experimental data
interfering effects
values
impacts
detecting
Prior art date
Application number
PCT/EP2003/002206
Other languages
French (fr)
Other versions
WO2003074994A2 (en
Inventor
Christian Eggeling
Kaupo Palo
Nicolas Fay
Maciej Hoffman-Wecker
Pierre Ilouga
Original Assignee
Evotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Ag filed Critical Evotec Ag
Priority to AU2003212303A priority Critical patent/AU2003212303A1/en
Priority to EP03708176A priority patent/EP1481236B1/en
Priority to DE60317049T priority patent/DE60317049T2/en
Publication of WO2003074994A2 publication Critical patent/WO2003074994A2/en
Publication of WO2003074994A3 publication Critical patent/WO2003074994A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of Mechanical Vibrations Or Ultrasonic Waves (AREA)

Abstract

A method of detecting impacts of interfering effects on experimental data resulting, e.g., from fluorescence measurements comprises the steps of: (i) providing the experimental data, (ii) determining values of one or a plurality of identification parameters, e.g. fluorescence intensity, from said data, (iii) creating a histogram or distribution of said values, (iv) determining one or a plurality of thresholds for said values from said histogram, which thresholds are indicative of interfering effects, (v) analysing said values whether or not they fulfill one or a plurality of criteria with respect to said thresholds, and (vi) determining those experimental data which are influenced and/or those experimental data which are not affected by the interfering effects.
PCT/EP2003/002206 2002-03-04 2003-03-04 A method for detecting the impacts of interfering effects on experimental data WO2003074994A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003212303A AU2003212303A1 (en) 2002-03-04 2003-03-04 A method for detecting the impacts of interfering effects on experimental data
EP03708176A EP1481236B1 (en) 2002-03-04 2003-03-04 A method for detecting the impacts of interfering effects on experimental data
DE60317049T DE60317049T2 (en) 2002-03-04 2003-03-04 METHOD FOR DETECTING THE IMPACT OF INTERFERENCE TO MEASUREMENT DATA

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004899A EP1343001A1 (en) 2002-03-04 2002-03-04 A method for identifying the impacts of interfering effects on secondary light emission data
EP02004899.7 2002-03-04

Publications (2)

Publication Number Publication Date
WO2003074994A2 WO2003074994A2 (en) 2003-09-12
WO2003074994A3 true WO2003074994A3 (en) 2003-12-24

Family

ID=27741125

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002206 WO2003074994A2 (en) 2002-03-04 2003-03-04 A method for detecting the impacts of interfering effects on experimental data

Country Status (5)

Country Link
EP (2) EP1343001A1 (en)
AT (1) ATE376668T1 (en)
AU (1) AU2003212303A1 (en)
DE (1) DE60317049T2 (en)
WO (1) WO2003074994A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010047237B4 (en) 2010-08-13 2021-07-01 Leica Microsystems Cms Gmbh Method for separating detection signals in the beam path of an optical device
KR20220052911A (en) * 2019-06-27 2022-04-28 에뮬레이트, 인크. Dispensing compounds in microfluidic devices

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5757022A (en) * 1995-10-19 1998-05-26 Fuji Photo Film Co., Ltd. Image processing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733721A (en) * 1992-11-20 1998-03-31 The Board Of Regents Of The University Of Oklahoma Cell analysis method using quantitative fluorescence image analysis
GB9621122D0 (en) * 1996-10-10 1996-11-27 Cambridge Imaging Ltd Improvements in and relating to methods and apparatus for assay analysis
AU6227900A (en) * 1999-07-21 2001-02-13 Tropix, Inc. Luminescence detection workstation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5757022A (en) * 1995-10-19 1998-05-26 Fuji Photo Film Co., Ltd. Image processing apparatus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DANZER K ET AL: "Chemometrik", 2001, SPRINGER, HEIDELBERG, BERLIN, XP002250629 *
KASK P ET AL: "TWO-DIMENSIONAL FLUORESCENCE INTENSITY DISTRIBUTION ANALYSIS: THEORY AND APPLICATIONS", BIOPHYSICAL JOURNAL, NEW YORK, US, US, vol. 78, no. 4, April 2000 (2000-04-01), pages 1703 - 1713, XP001006012, ISSN: 0006-3495 *

Also Published As

Publication number Publication date
WO2003074994A2 (en) 2003-09-12
DE60317049T2 (en) 2008-07-31
ATE376668T1 (en) 2007-11-15
AU2003212303A1 (en) 2003-09-16
EP1481236B1 (en) 2007-10-24
EP1481236A2 (en) 2004-12-01
DE60317049D1 (en) 2007-12-06
EP1343001A1 (en) 2003-09-10

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