WO2003072602A3 - Protein complexes and methods for their use - Google Patents

Protein complexes and methods for their use Download PDF

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Publication number
WO2003072602A3
WO2003072602A3 PCT/EP2002/050003 EP0250003W WO03072602A3 WO 2003072602 A3 WO2003072602 A3 WO 2003072602A3 EP 0250003 W EP0250003 W EP 0250003W WO 03072602 A3 WO03072602 A3 WO 03072602A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
protein complexes
complexes
protein
proteins
Prior art date
Application number
PCT/EP2002/050003
Other languages
French (fr)
Other versions
WO2003072602A2 (en
Inventor
Andreas Bauer
Anne-Claude Gavin
Gulio Superti-Furga
Bernhard Kuester
Joerg Schultz
Martina Marzioch
Paola Grandi
Roland Krause
Ulrich Kruse
Alejandro Merino
Angela Bauch
Anne-Marie Michon
Christina Leutwein
Jens Rick
Original Assignee
Cellzome Ag
Andreas Bauer
Anne-Claude Gavin
Gulio Superti-Furga
Bernhard Kuester
Joerg Schultz
Martina Marzioch
Paola Grandi
Roland Krause
Ulrich Kruse
Alejandro Merino
Angela Bauch
Anne-Marie Michon
Christina Leutwein
Jens Rick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01130253A external-priority patent/EP1258494A1/en
Application filed by Cellzome Ag, Andreas Bauer, Anne-Claude Gavin, Gulio Superti-Furga, Bernhard Kuester, Joerg Schultz, Martina Marzioch, Paola Grandi, Roland Krause, Ulrich Kruse, Alejandro Merino, Angela Bauch, Anne-Marie Michon, Christina Leutwein, Jens Rick filed Critical Cellzome Ag
Priority to AU2002367554A priority Critical patent/AU2002367554A1/en
Priority to CA002471307A priority patent/CA2471307A1/en
Publication of WO2003072602A2 publication Critical patent/WO2003072602A2/en
Publication of WO2003072602A3 publication Critical patent/WO2003072602A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Abstract

The present invention relates to multiprotein complexes from eukaryotes. The complexes are obtainable by using a protein as a bait and isolating the set of proteins which is attached thereto from cells. Such protein complexes may comprise up to 30 distinct proteins.
PCT/EP2002/050003 2001-12-20 2002-12-20 Protein complexes and methods for their use WO2003072602A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002367554A AU2002367554A1 (en) 2001-12-20 2002-12-20 Protein complexes and methods for their use
CA002471307A CA2471307A1 (en) 2001-12-20 2002-12-20 Protein complexes and methods for their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01130253.6 2001-12-20
EP01130253A EP1258494A1 (en) 2001-05-15 2001-12-20 Multiprotein complexes from eukaryotes

Publications (2)

Publication Number Publication Date
WO2003072602A2 WO2003072602A2 (en) 2003-09-04
WO2003072602A3 true WO2003072602A3 (en) 2004-04-15

Family

ID=27763328

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/050003 WO2003072602A2 (en) 2001-12-20 2002-12-20 Protein complexes and methods for their use

Country Status (3)

Country Link
AU (1) AU2002367554A1 (en)
CA (1) CA2471307A1 (en)
WO (1) WO2003072602A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394330B2 (en) 2012-03-21 2016-07-19 Alios Biopharma, Inc. Solid forms of a thiophosphoramidate nucleotide prodrug

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005079367A2 (en) 2004-02-13 2005-09-01 Martek Biosciences Corporation Schizochytrium fatty acid synthase (fas) and products and methods related thereto
CN100577805C (en) * 2005-03-16 2010-01-06 中国科学院沈阳应用生态研究所 Method of modifying gene and obtained recombinant gene and encoded protin
CN1861789B (en) * 2005-05-13 2010-04-28 中国科学院沈阳应用生态研究所 Integrated gene recombined process, recombined gene and coding protein obtained thereby
CA2687964A1 (en) 2007-06-01 2009-02-19 The Trustees Of Princeton University Treatment of viral infections by modulation of host cell metabolic pathways
RU2483107C2 (en) * 2007-07-31 2013-05-27 Сэ5 Лигно Текнолоджиз ин Лунд АБ Polypeptide having nadh-dependent hmf-reductase activity
PT104619A (en) * 2008-06-13 2009-12-14 Biocant Ct De Inovacao Em Biot PROTEIN COMPLEXES AND SCREENING METHODS
CN103209987B (en) 2010-09-22 2017-06-06 艾丽奥斯生物制药有限公司 Substituted nucleotide analog
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc Substituted phosphorothioate nucleotide analogs
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
KR102589523B1 (en) * 2017-02-17 2023-10-17 히야신스 바이오로지컬스 아이엔씨. Cell lines and methods for producing polyketides in yeast
CN113774074A (en) * 2020-06-05 2021-12-10 复旦大学 Peptide fragment-based targeted proteome accurate quantification method
WO2024030080A1 (en) * 2022-08-05 2024-02-08 Nanyang Technological University Adp-actin-specific protein and motifs to remodel actin cytoskeleton in living cells and in vitro biochemistry

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CONESA CHRISTINE ET AL: "On the subunit composition, stoichiometry, and phosphorylation of the yeast transcription factor TFIIIC/tau.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 24, 1993, pages 18047 - 18052, XP002255320, ISSN: 0021-9258 *
DEPREZ ERIC ET AL: "A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein.", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 12, December 1999 (1999-12-01), pages 8042 - 8051, XP002255321, ISSN: 0270-7306 *
ESCRIBANO V ET AL: "Hypothetical 145.6 KDA protein in RPL1B-CEG1 Intergenic region", SWISS-PROT, XP002199347 *
GELBART M E ET AL: "Interactions of Isw2 Chromatin Remodelling Complex with nucleosomal Arrays: Analyses Using Recombinant Yeast Histones and Immobilized Templates", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 21, no. 6, March 2001 (2001-03-01), pages 2098 - 2106, XP002199344, ISSN: 0270-7306 *
HUANG Y ET AL: "Isolation and Cloning of Four Subunits of a Fission Yeast TFIIIC Complex That Includes an Ortholog of the Human Regulatory Protein TFIIICbeta", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 275, no. 40, 6 October 2001 (2001-10-06), pages 31480 - 31487, XP002199346, ISSN: 0021-9258 *
PURRELLO M ET AL: "Genes for human general transcription initiation factors TFIIIB, TFIIIB-associated proteins, TFIIIC2 and PTF/SNAPC: functional and positional candidates for tumour predisposition or inherited genetic diseases?", ONCOGENE. ENGLAND 9 AUG 2001, vol. 20, no. 35, 9 August 2001 (2001-08-09), pages 4877 - 4883, XP002255322, ISSN: 0950-9232 *
RIGAUT G ET AL: "A generic protein purification method for protein complex characterization and proteome exploration", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 10, October 1999 (1999-10-01), pages 1030 - 1032, XP002179540, ISSN: 1087-0156 *
TSUKIYAMA T ET AL: "Characterisation of the Imitation Switch subfamily of ATP-dependent Chromatin-remodeling factors in Saccharomyces cerevisiae", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 13, 1999, pages 686 - 697, XP002199345, ISSN: 0890-9369 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394330B2 (en) 2012-03-21 2016-07-19 Alios Biopharma, Inc. Solid forms of a thiophosphoramidate nucleotide prodrug

Also Published As

Publication number Publication date
AU2002367554A1 (en) 2003-09-09
WO2003072602A2 (en) 2003-09-04
CA2471307A1 (en) 2003-09-04

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