WO2003070316A3 - Arrangement for receiving electrical signals from living cells and for stimulation - Google Patents

Arrangement for receiving electrical signals from living cells and for stimulation Download PDF

Info

Publication number
WO2003070316A3
WO2003070316A3 PCT/AT2003/000055 AT0300055W WO03070316A3 WO 2003070316 A3 WO2003070316 A3 WO 2003070316A3 AT 0300055 W AT0300055 W AT 0300055W WO 03070316 A3 WO03070316 A3 WO 03070316A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrangement
cell
stimulation
output
electrical signals
Prior art date
Application number
PCT/AT2003/000055
Other languages
German (de)
French (fr)
Other versions
WO2003070316A2 (en
Inventor
Emmerich Bertagnolli
Original Assignee
Innovationsagentur Gmbh
Emmerich Bertagnolli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovationsagentur Gmbh, Emmerich Bertagnolli filed Critical Innovationsagentur Gmbh
Priority to EP03706118A priority Critical patent/EP1476218A2/en
Priority to AU2003208165A priority patent/AU2003208165A1/en
Publication of WO2003070316A2 publication Critical patent/WO2003070316A2/en
Publication of WO2003070316A3 publication Critical patent/WO2003070316A3/en
Priority to US10/922,449 priority patent/US20050101995A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/06—Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons
    • G06N3/061—Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using biological neurons, e.g. biological neurons connected to an integrated circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin

Abstract

The invention relates to an arrangement for coupling a living cell, especially a neurone, to an electronic circuit for receiving directly or indirectly electrically active cell signals and/or for electrically stimulating the cell. Said arrangement comprises a passive electronic element (C1, R1) which is connected to a reference potential (M) by means of a connection and is connected to a switched output of an electronic switch (T1) by means of another connection. The input of said switch can be connected to a signal source or a voltage source (point B). An electroconductive contact element (1) can be brought into contact with the cell (2) and is connected between the output of the electrical switch (point P) and the connection of the passive electronic component (C1, R1) which is connected to said output.
PCT/AT2003/000055 2002-02-19 2003-02-19 Arrangement for receiving electrical signals from living cells and for stimulation WO2003070316A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03706118A EP1476218A2 (en) 2002-02-19 2003-02-19 Arrangement for receiving electrical signals from living cells and for the selective transmission of electrical stimulation to living cells
AU2003208165A AU2003208165A1 (en) 2002-02-19 2003-02-19 Arrangement for receiving electrical signals from living cells and for stimulation
US10/922,449 US20050101995A1 (en) 2002-02-19 2004-08-19 Arrangement for receiving electrical signals from living cells and for the selective transmission of electrical stimulation to living cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT2512002 2002-02-19
ATA251/2002 2002-02-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/922,449 Continuation US20050101995A1 (en) 2002-02-19 2004-08-19 Arrangement for receiving electrical signals from living cells and for the selective transmission of electrical stimulation to living cells

Publications (2)

Publication Number Publication Date
WO2003070316A2 WO2003070316A2 (en) 2003-08-28
WO2003070316A3 true WO2003070316A3 (en) 2004-01-08

Family

ID=27739926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2003/000055 WO2003070316A2 (en) 2002-02-19 2003-02-19 Arrangement for receiving electrical signals from living cells and for stimulation

Country Status (3)

Country Link
EP (1) EP1476218A2 (en)
AU (1) AU2003208165A1 (en)
WO (1) WO2003070316A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10351201B3 (en) * 2003-11-03 2005-07-14 Infineon Technologies Ag Neuro-sensor and process to manufacture a semiconductor neuro-sensor on a transistorized foundation structure

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001807A1 (en) * 1985-09-20 1987-03-26 H.S.G. Venture Neurological and biological molecular electro-optical devices and method
US5248899A (en) * 1992-02-07 1993-09-28 Dan Haronian Neural network using photoelectric substance
EP0645162A1 (en) * 1993-09-29 1995-03-29 Tech Pulse Cc Nerve stimulation apparatus and method
US5801428A (en) * 1996-06-12 1998-09-01 Siemens Aktiengesellschaft MOS transistor for biotechnical applications

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001807A1 (en) * 1985-09-20 1987-03-26 H.S.G. Venture Neurological and biological molecular electro-optical devices and method
US5248899A (en) * 1992-02-07 1993-09-28 Dan Haronian Neural network using photoelectric substance
EP0645162A1 (en) * 1993-09-29 1995-03-29 Tech Pulse Cc Nerve stimulation apparatus and method
US5801428A (en) * 1996-06-12 1998-09-01 Siemens Aktiengesellschaft MOS transistor for biotechnical applications

Also Published As

Publication number Publication date
EP1476218A2 (en) 2004-11-17
AU2003208165A8 (en) 2003-09-09
AU2003208165A1 (en) 2003-09-09
WO2003070316A2 (en) 2003-08-28

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