WO2003066844A3 - Cytochrome p450 protein - Google Patents

Cytochrome p450 protein Download PDF

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Publication number
WO2003066844A3
WO2003066844A3 PCT/GB2003/000545 GB0300545W WO03066844A3 WO 2003066844 A3 WO2003066844 A3 WO 2003066844A3 GB 0300545 W GB0300545 W GB 0300545W WO 03066844 A3 WO03066844 A3 WO 03066844A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
cytochrome
intp003
diagnosis
disease
Prior art date
Application number
PCT/GB2003/000545
Other languages
French (fr)
Other versions
WO2003066844A2 (en
Inventor
Richard Joseph Fagan
Christopher Benjamin Phelps
Ellie Louise James
Sarah Helen Kamp
Kirsty Louisa-Jane Leake
Katheryn Elizabeth Allen
Nelly Collinet
Janet Marjorie Allen
Original Assignee
Inpharmatica Ltd
Richard Joseph Fagan
Christopher Benjamin Phelps
Ellie Louise James
Sarah Helen Kamp
Kirsty Louisa-Jane Leake
Katheryn Elizabeth Allen
Nelly Collinet
Janet Marjorie Allen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inpharmatica Ltd, Richard Joseph Fagan, Christopher Benjamin Phelps, Ellie Louise James, Sarah Helen Kamp, Kirsty Louisa-Jane Leake, Katheryn Elizabeth Allen, Nelly Collinet, Janet Marjorie Allen filed Critical Inpharmatica Ltd
Priority to AU2003244413A priority Critical patent/AU2003244413A1/en
Priority to EP03737382A priority patent/EP1474506A2/en
Priority to CA002475230A priority patent/CA2475230A1/en
Publication of WO2003066844A2 publication Critical patent/WO2003066844A2/en
Publication of WO2003066844A3 publication Critical patent/WO2003066844A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/1303—Leukotriene-B4 20-monooxygenase (1.14.13.30), i.e. leukotriene-B4-omega-hydroxylase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to a novel protein (INTP003), herein identified as a P450 and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.
PCT/GB2003/000545 2002-02-06 2003-02-06 Cytochrome p450 protein WO2003066844A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003244413A AU2003244413A1 (en) 2002-02-06 2003-02-06 Cytochrome p450 protein
EP03737382A EP1474506A2 (en) 2002-02-06 2003-02-06 Cytochrome p450 protein
CA002475230A CA2475230A1 (en) 2002-02-06 2003-02-06 Cytochrome p450 protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0202748A GB0202748D0 (en) 2002-02-06 2002-02-06 Protein
GB0202748.0 2002-02-06

Publications (2)

Publication Number Publication Date
WO2003066844A2 WO2003066844A2 (en) 2003-08-14
WO2003066844A3 true WO2003066844A3 (en) 2003-09-12

Family

ID=9930517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/000545 WO2003066844A2 (en) 2002-02-06 2003-02-06 Cytochrome p450 protein

Country Status (5)

Country Link
EP (1) EP1474506A2 (en)
AU (1) AU2003244413A1 (en)
CA (1) CA2475230A1 (en)
GB (1) GB0202748D0 (en)
WO (1) WO2003066844A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1782806A1 (en) * 2005-11-04 2007-05-09 Centre National de Genotypage Compositions for treating dermatological and neurological disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001059127A2 (en) * 2000-02-11 2001-08-16 Incyte Genomics, Inc. Drug metabolizing enzymes
US20020022254A1 (en) * 2000-07-28 2002-02-21 Karl Guegler Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
WO2002050277A2 (en) * 2000-12-21 2002-06-27 Curagen Corporation Protein and nucleic acids encoding same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001059127A2 (en) * 2000-02-11 2001-08-16 Incyte Genomics, Inc. Drug metabolizing enzymes
US20020022254A1 (en) * 2000-07-28 2002-02-21 Karl Guegler Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
WO2002050277A2 (en) * 2000-12-21 2002-06-27 Curagen Corporation Protein and nucleic acids encoding same

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BYLUND JOHAN ET AL: "cDNA cloning and expression of CYP4F12, a novel human cytochrome P450.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 280, no. 3, 26 January 2001 (2001-01-26), pages 892 - 897, XP002246900, ISSN: 0006-291X *
DATABASE EMBL [online] 1 July 2002 (2002-07-01), "Human drug metabolizing enzyme cDNA", XP002246907, retrieved from EBI Database accession no. AAD32741 *
DATABASE EMBL [online] 1 October 1996 (1996-10-01), "CPF5 rat", XP002246904, retrieved from EBI Database accession no. P51870 *
DATABASE EMBL [online] 15 December 1998 (1998-12-15), "CPF2 human", XP002246903, retrieved from EBI Database accession no. P78329 *
DATABASE EMBL [online] 2 May 2001 (2001-05-02), "602621407F1 NCI cGAP Skn3 Homo sapiens cDNA", XP002246905, retrieved from EBI Database accession no. BG675134 *
DATABASE EMBL [online] 21 October 2002 (2002-10-21), "cDNA encoding human Nov10 protein", XP002246906, retrieved from EBI Database accession no. ABS51084 *
HASHIZUME TAKANORI ET AL: "cDNA cloning and expression of a novel cytochrome P450 (CYP4F12) from human small intestine.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 280, no. 4, 2 February 2001 (2001-02-02), pages 1135 - 1141, XP002246901, ISSN: 0006-291X *
KIKUTA Y ET AL: "CLONING AND EXPRESSION OF A NOVEL FORM OF LEUKOTRIENE B4 OMEGA-HYDROXYLASE FROM HUMAN LIVER", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 348, no. 1, July 1994 (1994-07-01), pages 70 - 74, XP002945915, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
EP1474506A2 (en) 2004-11-10
GB0202748D0 (en) 2002-03-27
AU2003244413A8 (en) 2003-09-02
WO2003066844A2 (en) 2003-08-14
AU2003244413A1 (en) 2003-09-02
CA2475230A1 (en) 2003-08-14

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