WO2003066820A3 - Nucleic acid molecules encoding cd1-derived endosomal targeting proteins and uses thereof - Google Patents

Nucleic acid molecules encoding cd1-derived endosomal targeting proteins and uses thereof Download PDF

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Publication number
WO2003066820A3
WO2003066820A3 PCT/US2003/003550 US0303550W WO03066820A3 WO 2003066820 A3 WO2003066820 A3 WO 2003066820A3 US 0303550 W US0303550 W US 0303550W WO 03066820 A3 WO03066820 A3 WO 03066820A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
interest
methods
endosomal targeting
nucleic acid
Prior art date
Application number
PCT/US2003/003550
Other languages
French (fr)
Other versions
WO2003066820A2 (en
Inventor
Robert L Modlin
Original Assignee
Univ California
Robert L Modlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Robert L Modlin filed Critical Univ California
Priority to AU2003216184A priority Critical patent/AU2003216184A1/en
Publication of WO2003066820A2 publication Critical patent/WO2003066820A2/en
Publication of WO2003066820A3 publication Critical patent/WO2003066820A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides chimeric nucleic acid molecules encoding CD1 fusion proteins, comprising a leader peptide sequence, a CD1 endosomal targeting sequence, and an antigen of interest. In the CD1 fusion protein, the leader peptide sequence and CD1 endosomal targeting sequence direct production, processing, trafficking, and cell surface presentation of the antigen of interest via the MHCII antigen presenting pathway. The invention also provides methods for producing the CD1 fusion protein or the antigen of interest or fragments thereof, methods for targeting the antigen of interest to the MHCII antigen presenting pathway, and methods for presenting on a cell the antigen of interest. Additionally, the present invention provides methods for inducing in a subject an immune response mediated by a CD1 endosomal targeting sequence, methods for inducing in a subject an immune response to an antigen of interest, and methods for inducing in a subject an immune response mediated by an MHCII antigen presenting pathway.
PCT/US2003/003550 2002-02-05 2003-02-05 Nucleic acid molecules encoding cd1-derived endosomal targeting proteins and uses thereof WO2003066820A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003216184A AU2003216184A1 (en) 2002-02-05 2003-02-05 Nucleic acid molecules encoding cd1-derived endosomal targeting proteins and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35543202P 2002-02-05 2002-02-05
US60/355,432 2002-02-05

Publications (2)

Publication Number Publication Date
WO2003066820A2 WO2003066820A2 (en) 2003-08-14
WO2003066820A3 true WO2003066820A3 (en) 2003-11-13

Family

ID=27734518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003550 WO2003066820A2 (en) 2002-02-05 2003-02-05 Nucleic acid molecules encoding cd1-derived endosomal targeting proteins and uses thereof

Country Status (2)

Country Link
AU (1) AU2003216184A1 (en)
WO (1) WO2003066820A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10347710B4 (en) 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Recombinant vaccines and their use
US20070269457A1 (en) * 2006-05-16 2007-11-22 The Buck Institute For Age Research Immunotherapeutic compositions and methods
US9279011B2 (en) 2009-05-05 2016-03-08 The Johns Hopkins University Phosphopeptides as melanoma vaccines
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
CA2807942C (en) 2010-08-10 2021-07-27 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
MX2016010835A (en) 2014-02-21 2017-07-11 Anokion Sa Glycotargeting therapeutics.
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10370419B2 (en) 2014-12-09 2019-08-06 The Board Of Regents Of The University Of Textas System Tuberculosis vaccine compositions and related methods
KR20180006402A (en) * 2015-05-22 2018-01-17 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Methods and compositions related to antigen-presenting proteins
EP3638296A1 (en) 2017-06-16 2020-04-22 The University Of Chicago Compositions and methods for inducing immune tolerance
CN111868077A (en) * 2018-01-17 2020-10-30 南特生物公司 Enhanced immunogenicity of GPI-anchored antigens
CN115552011A (en) * 2020-03-11 2022-12-30 免疫生物公司 COVID-19 treatment and methods
CN116554300B (en) * 2023-04-27 2023-10-24 湖北医药学院 Polypeptide capable of interacting with clostridium difficile toxin TcdB and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020071842A1 (en) * 2000-06-05 2002-06-13 Gumperz Jenny E. Soluble CD1 compositions and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020071842A1 (en) * 2000-06-05 2002-06-13 Gumperz Jenny E. Soluble CD1 compositions and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BILSLAND C.A.G. ET AL.: "The identification of the b2-microglobulin binding antigen encoded by the CD1D gene", EUR. J. IMMUNOL., vol. 21, 1991, pages 71 - 78, XP002965999 *
GEHO D.H. ET AL.: "Glycosyl-phosphatidylinositol reanchoring unmasks distinct antigen-presenting pathways for CD1b and CD1c", J. IMMUNOL., vol. 165, 2000, pages 1272 - 1277, XP002966000 *
SUGITA M. ET AL.: "Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs", SCIENCE, July 1996 (1996-07-01), pages 349 - 352, XP002965998 *
SUGITA M. ET AL.: "Pathways for lipid antigen presentation by CD1 molecules-nowhere for intracellular pathogens to hide", TRAFFIC, vol. 1, 2000, pages 295 - 300, XP002965997 *

Also Published As

Publication number Publication date
WO2003066820A2 (en) 2003-08-14
AU2003216184A1 (en) 2003-09-02
AU2003216184A8 (en) 2003-09-02

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