WO2003064999A3 - Methods for identifying modulators of receptor tyrosine kinases - Google Patents

Methods for identifying modulators of receptor tyrosine kinases Download PDF

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Publication number
WO2003064999A3
WO2003064999A3 PCT/US2003/002192 US0302192W WO03064999A3 WO 2003064999 A3 WO2003064999 A3 WO 2003064999A3 US 0302192 W US0302192 W US 0302192W WO 03064999 A3 WO03064999 A3 WO 03064999A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
receptor tyrosine
jki
tyrosine kinases
site
Prior art date
Application number
PCT/US2003/002192
Other languages
French (fr)
Other versions
WO2003064999A2 (en
Inventor
Stevan Hubbard
Jeffrey H Till
Shiqing Li
Evan Stein
Nicole Covino
Original Assignee
Univ New York
Stevan Hubbard
Jeffrey H Till
Shiqing Li
Evan Stein
Nicole Covino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York, Stevan Hubbard, Jeffrey H Till, Shiqing Li, Evan Stein, Nicole Covino filed Critical Univ New York
Priority to AU2003217247A priority Critical patent/AU2003217247A1/en
Publication of WO2003064999A2 publication Critical patent/WO2003064999A2/en
Publication of WO2003064999A3 publication Critical patent/WO2003064999A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Abstract

Screening methods for identifying small molecules capable of binding to the juxtamembrane-kinase interaction (JKI) site of the tyrosine kinase domain of the insulin receptor (IRK) to prevent or lessen constitutive inhibition of kinase activity. More generally, the invention relates to screening methods for identifying small molecules capable of binding to the JKI site of a tyrosine kinase domain, to modulate kinase activity in a receptor molecule comprising a JKI site.
PCT/US2003/002192 2002-01-25 2003-01-24 Methods for identifying modulators of receptor tyrosine kinases WO2003064999A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003217247A AU2003217247A1 (en) 2002-01-25 2003-01-24 Methods for identifying modulators of receptor tyrosine kinases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35192402P 2002-01-25 2002-01-25
US60/351,924 2002-01-25

Publications (2)

Publication Number Publication Date
WO2003064999A2 WO2003064999A2 (en) 2003-08-07
WO2003064999A3 true WO2003064999A3 (en) 2004-02-26

Family

ID=27663036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/002192 WO2003064999A2 (en) 2002-01-25 2003-01-24 Methods for identifying modulators of receptor tyrosine kinases

Country Status (2)

Country Link
AU (1) AU2003217247A1 (en)
WO (1) WO2003064999A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2047252B1 (en) * 2006-06-22 2013-01-23 Walter and Eliza Hall Institute of Medical Research Structure of the insulin receptor ectodomain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514981B1 (en) * 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514981B1 (en) * 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds

Also Published As

Publication number Publication date
AU2003217247A1 (en) 2003-09-02
WO2003064999A2 (en) 2003-08-07

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