WO2003064616A3 - Compounds and methods for inducing growth arrest and apoptosis - Google Patents

Compounds and methods for inducing growth arrest and apoptosis Download PDF

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Publication number
WO2003064616A3
WO2003064616A3 PCT/US2003/002942 US0302942W WO03064616A3 WO 2003064616 A3 WO2003064616 A3 WO 2003064616A3 US 0302942 W US0302942 W US 0302942W WO 03064616 A3 WO03064616 A3 WO 03064616A3
Authority
WO
WIPO (PCT)
Prior art keywords
apoptosis
growth arrest
compounds
methods
inducing growth
Prior art date
Application number
PCT/US2003/002942
Other languages
French (fr)
Other versions
WO2003064616A2 (en
Inventor
Stacey Jill Baker
E Premkumar Reddy
Original Assignee
Univ Temple
Stacey Jill Baker
E Premkumar Reddy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple, Stacey Jill Baker, E Premkumar Reddy filed Critical Univ Temple
Priority to AU2003210771A priority Critical patent/AU2003210771A1/en
Publication of WO2003064616A2 publication Critical patent/WO2003064616A2/en
Publication of WO2003064616A3 publication Critical patent/WO2003064616A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Growth arrest and apoptosis in cells can be induced in cells which are resistant to apoptosis with SUAP and derivatives, homologs and analogs of SUAP. Detection of endogenous SUAP expression can also be used as a marker of apoptosis in cells undergoing apoptosis-inducing therapeutic treatments.
PCT/US2003/002942 2002-01-31 2003-01-31 Compounds and methods for inducing growth arrest and apoptosis WO2003064616A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003210771A AU2003210771A1 (en) 2002-01-31 2003-01-31 Compounds and methods for inducing growth arrest and apoptosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35362202P 2002-01-31 2002-01-31
US60/353,622 2002-01-31

Publications (2)

Publication Number Publication Date
WO2003064616A2 WO2003064616A2 (en) 2003-08-07
WO2003064616A3 true WO2003064616A3 (en) 2005-02-24

Family

ID=27663230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/002942 WO2003064616A2 (en) 2002-01-31 2003-01-31 Compounds and methods for inducing growth arrest and apoptosis

Country Status (2)

Country Link
AU (1) AU2003210771A1 (en)
WO (1) WO2003064616A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074906A2 (en) * 2001-03-16 2002-09-26 Eli Lilly And Company Lp mammalian proteins; related reagents
AU2003226209B2 (en) * 2002-03-21 2008-10-23 Dana-Farber Cancer Institute, Inc. Inhibition of cell death responses induced by oxidative stress

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BAKER S.J.: "Small unstable apoptotic protein, an apoptosis-associated protein, suppresses proliferation of myeloid cells", CANCER RESEARCH, vol. 63, 1 February 2003 (2003-02-01), pages 705 - 712, XP002982904 *

Also Published As

Publication number Publication date
AU2003210771A1 (en) 2003-09-02
WO2003064616A2 (en) 2003-08-07

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