WO2003062469A3 - Gene matn3 or matrilin-3 linked to osteoarthritis treatment - Google Patents
Gene matn3 or matrilin-3 linked to osteoarthritis treatment Download PDFInfo
- Publication number
- WO2003062469A3 WO2003062469A3 PCT/IB2003/000342 IB0300342W WO03062469A3 WO 2003062469 A3 WO2003062469 A3 WO 2003062469A3 IB 0300342 W IB0300342 W IB 0300342W WO 03062469 A3 WO03062469 A3 WO 03062469A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- matn3
- gene
- matrilin
- linked
- osteoarthritis treatment
- Prior art date
Links
- 201000008482 osteoarthritis Diseases 0.000 title abstract 3
- 102000055008 Matrilin Proteins Human genes 0.000 title 1
- 108010072582 Matrilin Proteins Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101150001762 MATN3 gene Proteins 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003201737A AU2003201737A1 (en) | 2002-01-25 | 2003-01-23 | Gene matn3 or matrilin-3 linked to osteoarthritis treatment |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45370502P | 2002-01-25 | 2002-01-25 | |
US5731202A | 2002-01-25 | 2002-01-25 | |
US60/453,705 | 2002-01-25 | ||
US43153802P | 2002-12-05 | 2002-12-05 | |
US60/431,538 | 2002-12-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003062469A2 WO2003062469A2 (en) | 2003-07-31 |
WO2003062469A3 true WO2003062469A3 (en) | 2004-06-10 |
Family
ID=32397832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/000342 WO2003062469A2 (en) | 2002-01-25 | 2003-01-23 | Gene matn3 or matrilin-3 linked to osteoarthritis treatment |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2003062469A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0408684D0 (en) * | 2004-04-19 | 2004-05-19 | Guy S And St Thomas Hospital N | Diagnostic method |
GB0408685D0 (en) * | 2004-04-19 | 2004-05-19 | Guys & St Thomas Hospital Trus | Diagnostic method |
EP2285399A2 (en) * | 2008-05-22 | 2011-02-23 | Schering Corporation | Egf-a domain-mediated modulation of pcsk9 for treating lipid disorders |
CN116196394A (en) * | 2023-01-19 | 2023-06-02 | 苏州大学 | Application of recombinant human Matrilin-3 protein in preparing medicament for treating cerebrovascular diseases |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073479A1 (en) * | 1999-05-28 | 2000-12-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
-
2003
- 2003-01-23 WO PCT/IB2003/000342 patent/WO2003062469A2/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073479A1 (en) * | 1999-05-28 | 2000-12-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
Non-Patent Citations (8)
Title |
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BELLUOCCIO D ET AL: "Characterization of human matrilin-3 (MATN3).", GENOMICS. UNITED STATES 1 NOV 1998, vol. 53, no. 3, 1 November 1998 (1998-11-01), pages 391 - 394, XP002243331, ISSN: 0888-7543 * |
BELLUOCCIO D ET AL: "Matrilin-3 from chicken cartilage.", FEBS LETTERS. NETHERLANDS 29 SEP 1997, vol. 415, no. 2, 29 September 1997 (1997-09-29), pages 212 - 216, XP002243332, ISSN: 0014-5793 * |
BRIGGS MICHAEL D ET AL: "Pseudoachondroplasia and multiple epiphyseal dysplasia: mutation review, molecular interactions, and genotype to phenotype correlations.", HUMAN MUTATION. UNITED STATES MAY 2002, vol. 19, no. 5, May 2002 (2002-05-01), pages 465 - 478, XP002243335, ISSN: 1098-1004 * |
CHAPMAN K L ET AL: "Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia.", NATURE GENETICS. UNITED STATES AUG 2001, vol. 28, no. 4, August 2001 (2001-08-01), pages 393 - 396, XP002243334, ISSN: 1061-4036 * |
STEFÁNSSON STEFÁN EINAR ET AL: "Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3.", AMERICAN JOURNAL OF HUMAN GENETICS. UNITED STATES JUN 2003, vol. 72, no. 6, June 2003 (2003-06-01), pages 1448 - 1459, XP002243329, ISSN: 0002-9297 * |
UNGER S ET AL: "Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments.", AMERICAN JOURNAL OF MEDICAL GENETICS. UNITED STATES 2001 WINTER, vol. 106, no. 4, January 2001 (2001-01-01), pages 244 - 250, XP002243336, ISSN: 0148-7299 * |
WAGENER R ET AL: "Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor.", FEBS LETTERS. NETHERLANDS 11 AUG 1997, vol. 413, no. 1, 11 August 1997 (1997-08-11), pages 129 - 134, XP002243333, ISSN: 0014-5793 * |
WAGENER R ET AL: "Structure and mapping of the mouse matrilin-3 gene (Matn3), a member of a gene family containing a U12-type AT-AC intron.", MAMMALIAN GENOME: OFFICIAL JOURNAL OF THE INTERNATIONAL MAMMALIAN GENOME SOCIETY. UNITED STATES FEB 2000, vol. 11, no. 2, February 2000 (2000-02-01), pages 85 - 90, XP002243330, ISSN: 0938-8990 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003062469A2 (en) | 2003-07-31 |
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