WO2003060124A1 - Nouvelles proteines participant a la reaction de stress par l'activation de la map kinase p38, et genes codant lesdites proteines - Google Patents

Nouvelles proteines participant a la reaction de stress par l'activation de la map kinase p38, et genes codant lesdites proteines Download PDF

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Publication number
WO2003060124A1
WO2003060124A1 PCT/JP2002/008270 JP0208270W WO03060124A1 WO 2003060124 A1 WO2003060124 A1 WO 2003060124A1 JP 0208270 W JP0208270 W JP 0208270W WO 03060124 A1 WO03060124 A1 WO 03060124A1
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WIPO (PCT)
Prior art keywords
genes
mapk
activation
stress response
response via
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PCT/JP2002/008270
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English (en)
Japanese (ja)
Inventor
Hideki Inoue
Minoru Tateno
Kunihiro Matsumoto
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Japan Science And Technology Corporation
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Publication date
Application filed by Japan Science And Technology Corporation filed Critical Japan Science And Technology Corporation
Publication of WO2003060124A1 publication Critical patent/WO2003060124A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne les protéines (a) et (b) suivantes, ainsi que des gènes codant respectivement lesdites protéines (a) et (b): (a) une protéine contenant une séquence d'acides aminés représentée par SEQ ID NO:2 ou 4; (b) une protéine contenant une séquence d'acides aminés issue d'une séquence d'acides aminés représentée par SEQ ID NO:2 ou 4, par substitution, délétion, insertion et/ou addition d'au moins un acide aminé. Les protéines selon l'invention présentent la propriété d'activer la MAP kinase p38.
PCT/JP2002/008270 2002-01-11 2002-08-14 Nouvelles proteines participant a la reaction de stress par l'activation de la map kinase p38, et genes codant lesdites proteines WO2003060124A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002005348A JP4094294B2 (ja) 2002-01-11 2002-01-11 ｐ３８ＭＡＰＫの活性化を介してストレス応答に関与する新規タンパク質およびその遺伝子
JP2002-5348 2002-01-11

Publications (1)

Publication Number Publication Date
WO2003060124A1 true WO2003060124A1 (fr) 2003-07-24

Family

ID=19191096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008270 WO2003060124A1 (fr) 2002-01-11 2002-08-14 Nouvelles proteines participant a la reaction de stress par l'activation de la map kinase p38, et genes codant lesdites proteines

Country Status (2)

Country Link
JP (1) JP4094294B2 (fr)
WO (1) WO2003060124A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001071042A2 (fr) * 2000-03-23 2001-09-27 Pe Corporation (Ny) Necessaires de detection, tels que des jeux ordonnes d'echantillons d'acide nucleique, servant a detecter l'expression d'au moins 10.000 genes de drosophila et leur utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001071042A2 (fr) * 2000-03-23 2001-09-27 Pe Corporation (Ny) Necessaires de detection, tels que des jeux ordonnes d'echantillons d'acide nucleique, servant a detecter l'expression d'au moins 10.000 genes de drosophila et leur utilisation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GERWINS P. et al., "Cloning of a novel mitogen-activated protein kinase , MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.," J.Biol.Chem., 1997, Vol. 272, No. 13, pages 8288 - 8295 *
Hideki INOUE et al., "Shojaobae MAPKKK, D-MEKK1, wa p38 MAPK no Kasseika o Kaishite Stress Oto ni Kanyo suru", Dai 24 Kai The Molecular Biology Society of Japan Nenkai Program, Koen Yoshishu, Nenkai Soshiki Iinkai, 26 November, 2001, page 685, 3p-469 *
INOUE H. et al., "A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK", The EMBO Journal 2001, Vol. 20, No. 19, pages 5421 - 5430 *

Also Published As

Publication number Publication date
JP4094294B2 (ja) 2008-06-04
JP2003204791A (ja) 2003-07-22

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