WO2003059352A3 - Use of a novel class of drugs for the treatment of parasitic diseases - Google Patents

Use of a novel class of drugs for the treatment of parasitic diseases Download PDF

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Publication number
WO2003059352A3
WO2003059352A3 PCT/FR2003/000107 FR0300107W WO03059352A3 WO 2003059352 A3 WO2003059352 A3 WO 2003059352A3 FR 0300107 W FR0300107 W FR 0300107W WO 03059352 A3 WO03059352 A3 WO 03059352A3
Authority
WO
WIPO (PCT)
Prior art keywords
drugs
treatment
parasitic diseases
novel class
parasitic
Prior art date
Application number
PCT/FR2003/000107
Other languages
French (fr)
Other versions
WO2003059352A2 (en
WO2003059352B1 (en
Inventor
Stanislas Tomavo
Florence Dzierszinski
Alexandra Coppin
Bels Frederic De
Jean-Claude Ameisen
Original Assignee
Centre Nat Rech Scient
Stanislas Tomavo
Florence Dzierszinski
Alexandra Coppin
Bels Frederic De
Jean-Claude Ameisen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Stanislas Tomavo, Florence Dzierszinski, Alexandra Coppin, Bels Frederic De, Jean-Claude Ameisen filed Critical Centre Nat Rech Scient
Priority to AU2003214317A priority Critical patent/AU2003214317A1/en
Publication of WO2003059352A2 publication Critical patent/WO2003059352A2/en
Publication of WO2003059352A3 publication Critical patent/WO2003059352A3/en
Publication of WO2003059352B1 publication Critical patent/WO2003059352B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to the use of at least one ligand molecule of the peripheral benzodiazepine receptor (PBR) for the production of drugs that are intended for the treatment of parasitic diseases.
PCT/FR2003/000107 2002-01-15 2003-01-14 Use of a novel class of drugs for the treatment of parasitic diseases WO2003059352A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003214317A AU2003214317A1 (en) 2002-01-15 2003-01-14 Use of a novel class of drugs for the treatment of parasitic diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0200439A FR2834637A1 (en) 2002-01-15 2002-01-15 USE OF A NEW CLASS OF MEDICAMENTS FOR THE TREATMENT OF PARASITIC DISEASES
FR02/00439 2002-01-15

Publications (3)

Publication Number Publication Date
WO2003059352A2 WO2003059352A2 (en) 2003-07-24
WO2003059352A3 true WO2003059352A3 (en) 2004-03-11
WO2003059352B1 WO2003059352B1 (en) 2004-04-15

Family

ID=8871295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/000107 WO2003059352A2 (en) 2002-01-15 2003-01-14 Use of a novel class of drugs for the treatment of parasitic diseases

Country Status (3)

Country Link
AU (1) AU2003214317A1 (en)
FR (1) FR2834637A1 (en)
WO (1) WO2003059352A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2894478B1 (en) * 2005-12-08 2008-06-06 Anticiper Et Developper L Inno APPLICATION OF ISOQUINOLINE CARBOXAMIDE AND ITS DERIVATIVES AS BACTERIAL VIRULENCE INHIBITORS AS REPLACEMENT OR COMPLEMENT TO CLASSIC ANTIBIOTICS
WO2007088528A1 (en) * 2006-02-03 2007-08-09 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Microtubule targeting agents
GB0907284D0 (en) 2009-04-28 2009-06-10 Queen Mary & Westfield College Compounds for inducing cellular apoptosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046890A (en) * 1974-06-28 1977-09-06 Hoffmann-La Roche Inc. Benzodiazepine derivatives
US5182387A (en) * 1991-10-30 1993-01-26 Merrell Dow Pharmaceuticals Inc. Bis-dibenzoazepine compounds
WO2001051922A2 (en) * 2000-01-14 2001-07-19 Mitokor Identification of peripheral benzodiazepine receptor binding agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046890A (en) * 1974-06-28 1977-09-06 Hoffmann-La Roche Inc. Benzodiazepine derivatives
US5182387A (en) * 1991-10-30 1993-01-26 Merrell Dow Pharmaceuticals Inc. Bis-dibenzoazepine compounds
WO2001051922A2 (en) * 2000-01-14 2001-07-19 Mitokor Identification of peripheral benzodiazepine receptor binding agents

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BENNETT J L: "CHARACTERISTICS OF ANTI SCHISTOSOMAL BENZODIAZEPINE BINDING SITES IN SCHISTOSOMA-MANSONI", JOURNAL OF PARASITOLOGY, vol. 66, no. 5, 1980, pages 742 - 747, XP008006844, ISSN: 0022-3395 *
DE CARNERI, IVO: "Drug sensitivity of Hartmannella and Naegleria causative agents of meningoencephalitis", RIV. PARASSITOL. (1970), 31(1), 1-8, XP008006854 *
DZIERSZINSKI, FLORENCE ET AL: "Ligands of the peripheral benzodiazepine receptor are potent inhibitors of Plasmodium falciparum and Toxoplasma gondii in vitro", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY ( 2002 ), 46(10), 3197-3207, XP002239758 *
ESTAMBALE, B. B. A. ET AL: "The efficacy of 22,23-dihydroavermectin B1 (Ivermectin) acting singly or in combination with a benzodiazepine on microfilariae of Onchocerca species and Brugia pahangi (an in vitro study)", ZENTRALBL. BAKTERIOL. (1989), 271(2), 249-55, XP008006852 *
GELLRICH SYLKE ET AL: "In vitro effects of benzodiazepines against Leishmania mexicana amazoniensis and Trypanosoma cruzi.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 104, no. 4, 1995, Annual Meeting of the Society for Investigative Dermatology;Chicago, Illinois, USA; May 24-28, 1995, pages 686, XP008006846, ISSN: 0022-202X *
NEAL, R. A. ET AL: "In vitro anti-leishmanial activity of compounds in current clinical use for unrelated diseases", DRUGS EXP. CLIN. RES. (1988), 14(10), 621-8, XP008005467 *
PAX R ET AL: "A BENZODIAZEPINE DERIVATIVE AND PRAZIQUANTEL EFFECTS ON MUSCULATURE OF SCHISTOSOMA-MANSONI AND SCHISTOSOMA-JAPONICUM", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 304, no. 3, 1978, EN, pages 309 - 316, XP008006838, ISSN: 0028-1298 *
ZUCCOTTO, F. ET AL: "Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2001), 36(5), 395-405, XP004254750 *

Also Published As

Publication number Publication date
WO2003059352A2 (en) 2003-07-24
AU2003214317A1 (en) 2003-07-30
WO2003059352B1 (en) 2004-04-15
FR2834637A1 (en) 2003-07-18

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