WO2003058233A1 - Method of screening compound having fungal cell wall synthesis inhibitory activity - Google Patents

Method of screening compound having fungal cell wall synthesis inhibitory activity Download PDF

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Publication number
WO2003058233A1
WO2003058233A1 PCT/JP2002/013807 JP0213807W WO03058233A1 WO 2003058233 A1 WO2003058233 A1 WO 2003058233A1 JP 0213807 W JP0213807 W JP 0213807W WO 03058233 A1 WO03058233 A1 WO 03058233A1
Authority
WO
WIPO (PCT)
Prior art keywords
cell wall
fungal cell
inhibitory activity
wall synthesis
screening compound
Prior art date
Application number
PCT/JP2002/013807
Other languages
French (fr)
Japanese (ja)
Inventor
Kappei Tsukahara
Toshitaka Sato
Kazutaka Nakamoto
Mamiko Tsuchiya
Koji Sagane
Original Assignee
Eisai Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co., Ltd. filed Critical Eisai Co., Ltd.
Priority to AU2002357533A priority Critical patent/AU2002357533A1/en
Publication of WO2003058233A1 publication Critical patent/WO2003058233A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

By a simple binding assay with the use of a membrane fraction in which GWT1 protein is expressed, a compound inhibiting the transport of GPI anchor protein to fungal cell wall can be screened.
PCT/JP2002/013807 2001-12-28 2002-12-27 Method of screening compound having fungal cell wall synthesis inhibitory activity WO2003058233A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002357533A AU2002357533A1 (en) 2001-12-28 2002-12-27 Method of screening compound having fungal cell wall synthesis inhibitory activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-401947 2001-12-28
JP2001401947A JP2005168301A (en) 2001-12-28 2001-12-28 Method for screening compound having fungal cell wall synthesis-inhibiting activity

Publications (1)

Publication Number Publication Date
WO2003058233A1 true WO2003058233A1 (en) 2003-07-17

Family

ID=19189897

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/013807 WO2003058233A1 (en) 2001-12-28 2002-12-27 Method of screening compound having fungal cell wall synthesis inhibitory activity

Country Status (3)

Country Link
JP (1) JP2005168301A (en)
AU (1) AU2002357533A1 (en)
WO (1) WO2003058233A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048604A1 (en) * 2002-11-22 2004-06-10 Eisai Co., Ltd. Method of screening compound inhibiting enzymatic activity of gwt1 gene product
CN1313828C (en) * 2004-07-20 2007-05-02 中国人民解放军第二军医大学 Antifungal agent screening reagent kit

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013666A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. (8α,13Aβ)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quinolizines and intermediates thereto
WO2000001387A1 (en) * 1998-07-01 2000-01-13 Celgro, A Division Of Celgene Corporation Fungal growth inhibitors
WO2002004626A1 (en) * 2000-07-07 2002-01-17 Eisai Co., Ltd. Fungal cell wall synthesis gene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013666A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. (8α,13Aβ)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quinolizines and intermediates thereto
WO2000001387A1 (en) * 1998-07-01 2000-01-13 Celgro, A Division Of Celgene Corporation Fungal growth inhibitors
WO2002004626A1 (en) * 2000-07-07 2002-01-17 Eisai Co., Ltd. Fungal cell wall synthesis gene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAWARABAYASHI ET AL.: "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, aeropyrum pernix K1", DNA RES., vol. 6, 1999, pages 83 - 101, XP002966854 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048604A1 (en) * 2002-11-22 2004-06-10 Eisai Co., Ltd. Method of screening compound inhibiting enzymatic activity of gwt1 gene product
US8323917B2 (en) 2002-11-22 2012-12-04 National Institute Of Advanced Industrial Science And Technology Method of screening for compounds that inhibit the enzymatic activity of GWT1 gene product
CN1313828C (en) * 2004-07-20 2007-05-02 中国人民解放军第二军医大学 Antifungal agent screening reagent kit

Also Published As

Publication number Publication date
JP2005168301A (en) 2005-06-30
AU2002357533A1 (en) 2003-07-24

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