WO2003057204A3 - Modulation of iamt (pimt or pcmt) in immune system - Google Patents

Modulation of iamt (pimt or pcmt) in immune system Download PDF

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Publication number
WO2003057204A3
WO2003057204A3 PCT/EP2003/000079 EP0300079W WO03057204A3 WO 2003057204 A3 WO2003057204 A3 WO 2003057204A3 EP 0300079 W EP0300079 W EP 0300079W WO 03057204 A3 WO03057204 A3 WO 03057204A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulation
immune system
iamt
pcmt
pimt
Prior art date
Application number
PCT/EP2003/000079
Other languages
French (fr)
Other versions
WO2003057204A2 (en
Inventor
Paul Andreas Compare Cloos
Original Assignee
Nordic Bioscience As
Paul Andreas Compare Cloos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordic Bioscience As, Paul Andreas Compare Cloos filed Critical Nordic Bioscience As
Priority to AU2003235799A priority Critical patent/AU2003235799A1/en
Publication of WO2003057204A2 publication Critical patent/WO2003057204A2/en
Publication of WO2003057204A3 publication Critical patent/WO2003057204A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

Modulation of L-Isoaspartyl (D-Aspartyl) O-Methyltransferase activity in immune system associated cells enables the prevention or alleviation of an autoimmune response by decreasing self-antigen presentation or T-cell proliferation.
PCT/EP2003/000079 2002-01-08 2003-01-07 Modulation of iamt (pimt or pcmt) in immune system WO2003057204A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003235799A AU2003235799A1 (en) 2002-01-08 2003-01-07 Modulation of iamt (pimt or pcmt) in immune system

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34670902P 2002-01-08 2002-01-08
US60/346,709 2002-01-08
DKPA200200026 2002-01-08
DKPA200200026 2002-01-08

Publications (2)

Publication Number Publication Date
WO2003057204A2 WO2003057204A2 (en) 2003-07-17
WO2003057204A3 true WO2003057204A3 (en) 2004-02-05

Family

ID=26069124

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000079 WO2003057204A2 (en) 2002-01-08 2003-01-07 Modulation of iamt (pimt or pcmt) in immune system

Country Status (2)

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AU (1) AU2003235799A1 (en)
WO (1) WO2003057204A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1680120A2 (en) 2003-11-03 2006-07-19 Probiodrug AG Combinations useful for the treatment of neuronal disorders
FR2862661B1 (en) * 2003-11-26 2007-10-05 Agronomique Inst Nat Rech USE OF L-ISOASPARTYL METHYLTRANSFERASE AS A MARKER FOR LONGEVITY OF SEEDS.
CN1918131B (en) 2004-02-05 2011-05-04 前体生物药物股份公司 Novel inhibitors of glutaminyl cyclase
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
SI2091948T1 (en) 2006-11-30 2012-07-31 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
DK2142514T3 (en) 2007-04-18 2015-03-23 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (en) 2010-03-03 2016-11-16 プロビオドルグ エージー Inhibitors of glutaminyl cyclase
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
JP6050264B2 (en) 2011-03-16 2016-12-21 プロビオドルグ エージー Benzimidazole derivatives as inhibitors of glutaminyl cyclase
PL3461819T3 (en) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitors of glutaminyl cyclase

Citations (10)

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Publication number Priority date Publication date Assignee Title
US3100207A (en) * 1959-07-08 1963-08-06 Smith Kline French Lab 10-aminoalkylbenzo[b,f]thiepin and -dibenz[b,f]oxepin derivatives
GB1080979A (en) * 1964-11-03 1967-08-31 J U Geigy A G New thiepin and wxepin derivatives
GB1098347A (en) * 1964-06-29 1968-01-10 Geigy Ag J R New oxepin derivatives, their production and use
US3641056A (en) * 1970-01-06 1972-02-08 Ciba Geigy Corp 10-(aminomethyl)- and (aminoethyl)-dibenz (b f)oxepins
EP0726265A1 (en) * 1995-02-08 1996-08-14 Ciba-Geigy Ag 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity
WO1997045422A1 (en) * 1996-05-30 1997-12-04 Novartis Ag ANTI-NEURODEGENERATIVELY EFFECTIVE 10-AMINOALIPHATYL-DIBENZ[b,f]OXEPINE SALTS
WO1998015647A1 (en) * 1996-10-08 1998-04-16 Novartis Ag Modulation of apoptosis
WO2001083719A2 (en) * 2000-04-28 2001-11-08 Millennium Pharmaceuticals, Inc. 25692, a novel human o-methyltransferase family member and uses thereof
WO2002008395A2 (en) * 2000-07-14 2002-01-31 Millennium Pharmaceuticals, Inc. Putative human methyltransferase family member and uses thereof
WO2002052016A2 (en) * 2000-12-26 2002-07-04 Bayer Aktiengesellschaft Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3100207A (en) * 1959-07-08 1963-08-06 Smith Kline French Lab 10-aminoalkylbenzo[b,f]thiepin and -dibenz[b,f]oxepin derivatives
GB1098347A (en) * 1964-06-29 1968-01-10 Geigy Ag J R New oxepin derivatives, their production and use
GB1080979A (en) * 1964-11-03 1967-08-31 J U Geigy A G New thiepin and wxepin derivatives
US3641056A (en) * 1970-01-06 1972-02-08 Ciba Geigy Corp 10-(aminomethyl)- and (aminoethyl)-dibenz (b f)oxepins
EP0726265A1 (en) * 1995-02-08 1996-08-14 Ciba-Geigy Ag 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity
US5780500A (en) * 1995-02-08 1998-07-14 Novartis Corporation Anti-neurodegeneratively active 10-aminoaliphatyl-dibenzi b,f! oxepines
WO1997045422A1 (en) * 1996-05-30 1997-12-04 Novartis Ag ANTI-NEURODEGENERATIVELY EFFECTIVE 10-AMINOALIPHATYL-DIBENZ[b,f]OXEPINE SALTS
WO1998015647A1 (en) * 1996-10-08 1998-04-16 Novartis Ag Modulation of apoptosis
WO2001083719A2 (en) * 2000-04-28 2001-11-08 Millennium Pharmaceuticals, Inc. 25692, a novel human o-methyltransferase family member and uses thereof
WO2002008395A2 (en) * 2000-07-14 2002-01-31 Millennium Pharmaceuticals, Inc. Putative human methyltransferase family member and uses thereof
WO2002052016A2 (en) * 2000-12-26 2002-07-04 Bayer Aktiengesellschaft Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme

Non-Patent Citations (6)

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Title
DOROTEA MÜCK-SELER ET AL: "TCH-346 novartis.", I DRUGS, vol. 3, no. 5, 2000, pages 530 - 535, XP002902887, ISSN: 1369-7056 *
HUEBSCHER K J ET AL: "Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis.", GENE, vol. 240, 1999, pages 333 - 341, XP002902939, ISSN: 0378-1119 *
PERNA A F ET AL: "Metabolic consequences of Hyperhomocysteinemia in uremia.", AMERICAN JOURNAL OF KIDNEY DISEASES, vol. 38, no. 4 suppl 1, October 2001 (2001-10-01), pages s85 - s90, XP002902941, ISSN: 0272-6386 *
TSAI W ET AL: "Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 203, no. 1, 30 August 1994 (1994-08-30), pages 491 - 497, XP002902942, ISSN: 0006-291x *
XIAODONG CHENG ET AL: "Adomet- dependent methylation, DNA methyltransferases and base flipping.", NUCLEIC ACIDS RESEARCH SURVEY AND SUMMARY, vol. 29, no. 18, 2001, XP002902940 *
ZIMMERMANN K ET AL: "Dibenzoxepines as treatments for neurodegenerative diseases.", PURE APPL. CHEM., vol. 71, no. 11, 1999, pages 2039 - 2046, XP002902886 *

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Publication number Publication date
WO2003057204A2 (en) 2003-07-17
AU2003235799A8 (en) 2003-07-24
AU2003235799A1 (en) 2003-07-24

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