WO2003055550A1

WO2003055550A1 - Device for inhaling powder-like medicinal agents

Info

Publication number: WO2003055550A1
Application number: PCT/RU2001/000564
Authority: WO
Inventors: Aleksandr Grigorievich Chuchalin; Gennady Grigorievich Ryazhsky; Evgeny Viktorovich Babarskov
Original assignee: Chuchalin Aleksandr Grigorievi; Gennady Grigorievich Ryazhsky; Evgeny Viktorovich Babarskov
Priority date: 2001-12-25
Filing date: 2001-12-25
Publication date: 2003-07-10
Also published as: AU2002251610A1

Abstract

The invention relates to medical equipment. The inventive device for inhaling powder-like medicinal agents comprises a body provided with air intake and aerosol output orifices which are connected with the aid of an air conduit. The inventive dispergator is embodied in the form of a cylindrical chamber provided with an input socket which is tangentially arranged near a first base and an output socket which is coaxially arranged and passing through said base. Said output socket is recessed into the cylindrical chamber in such away that the input hole thereof is disposed in an axial direction between said socket and a second base. The inventive device also comprises a universal reusable demountable head, whose input socket is provided with a jointing sleeve for the connection thereof to the air conduit. Said head comprises the dispergator, a reservoir for collecting coarsely dispersed powder particles embodied in such a way that it is coaxially collapsible with respect to the cylindrical chamber of the dispergator and connected to the hollow thereof with the aid of a slotted hole which is embodied in the lateral wall thereof near a second base.

Description

SERVICES FOR ΗGΑLATION ΕΚΑΡСΕΚΑΡЫΧ СΡΕДСΤΒ

Β ΒIDΕ ПΟΡΟШΚΑ

ΑΟΑΑΤΤ ΤΕΧΗИΚИ

The invention is subject to medical technology, and the name κ

DEVICES FOR INDIVIDUAL INTRODUCTION

Easy-to-use drugs for light people.

ΡΕΤΕΧΗΕΤΒΤΒΡΟΒΕΗΡΟΒΕΗΡΟΒΕΗΡΟΒΕΗΡΟΒΕΗΡΟΒΕΗΡΟΒΕΗ ΤΕΧΗΤΕΧΗΡΟΒΕΗΚ

When using inhalation devices for inhalation purposes

DRUGS DISCUSSES A PROBLEM RELATED TO

significant medicinal products in the result of it

Precipitation in the upper air. At the same time, it is inhaled.

Doses benefit from the weakening of the healing effect and cause

undesirable effects. Due to loose bulk properties and

high adhesion to tehnologicheskimi to the impairments of the tonnal dispersion

Dosage of various medicinal products are known to be of concern to them

exact delivery. Therefore, many manufacturers of new products

inhaled medicinal products in case of release of parchment

mixtures of active particulate matter less than 10

μm, with partitioned particles of a foreign carrier with a size of 30-100

ukm, and the widespread use of devices intended for their use.

SIGNIFICANT FOX (DR. 26) One of the technical results, to achieve short-circuiting

SUMMARY OF INVENTIONS IN THIS AREA, DISCLOSURE OF AGRICULTURAL PRODUCTS

General medicine, and also the department

subdivision of particles of the inhalation of respirable dispersible fraction.

Known device for inhalation [1], which is supplied by inhalation

Cameras that take the device in the form of a small drum with the recipients

cameras and mouthpiece. The mouthpiece is equipped with a message service.

an air channel with an external operating device at a level

a displaced output outlet of the incoming camera.

The main mouthpiece and the rotational axis of the drum are the corner in

range from 70 ° to 110 °.

The inhalant [2] has been known, which is a short-lived inhalant, the medication for

DOSAGE FOR DRUGS, DISPERSION CAMERA, EXIT CHANNEL AND

a mouthpiece made with a large camera.

As is evident from the components described above, none of them

does not guarantee the user to protect against the loss of a distributed unit

Particles are inspiratory flow and the other way, as well as separate

the particles are located in the industrial area and may be trapped in the air

ποτοκοm. Separate agglomerates of the medicinal product reduce

The measured dose, and even the second, this dose may increase for

THROUGH THAT THERE AGREEMENTS CARRIED OUT BY AIR TRAINS MAY

SIGNIFICANT FOX (DR. 26) ADD TO EXTENDED DOSE, WHICH LEADS TO DECREASE OF PRECISION

dozryvki.

Known devices for the introduction of drugs [3], quick

It contains the operating system, which are connected by the central

In contrast, a bunker and a mixing chamber, which is connected to

atmospheric air ducts. The mouthpiece is movable,

and on it the dose is secured in the form of a part with the floor, apart from that, on

the mouthpiece is also locked with a closed screen.

Also known are devices for administering drugs [4],

The main compartment is equipped with a bunker and fresh dishes, in which

It is located in an open area with a boot screen, a dual channel and

tourism boom. In the bus terminal, you can use the mouthpiece

with access to land, inclined by liability, and even on

on the mouthpiece, with the possibility of regulation, a protective screen is used.

The indicated inventions: [3], [4] are aimed at achieving the effect

reduce the cost of treatment of the patient and his / her

lungs.

However, part of the large agglomeration of drug particles is not

Dispersed in a dispersion, either remains in it, or falls in

aerosol flow and settles in the throat, causing a number of undesirable

local and systemic side effects (urinary cough,

SIGNIFICANT FOX (DR. 26) disputes, oral candidiasis and others.), Particularly Displaced

the use of inhaled glucocorticosteroids.

A related invention is an inhaler for administration

medicinal products in the form of a powder [5]. DEVICES CONNECT WITH

Inlets for air inlet and outlet connected

drive with a dispersion installed in it. Dispersion

performed in the form of a direct cycle with tangential implications in

Lateral wall for air inlet and axial opening in the base for

Deliveries of a ready-mixed mixture, can be supplied with a ready-made mixture and a product made with

It is possible to move the dose from the tank to the air.

Inhalation works the following way. Air through the air

inhalation, measured delivery through a non-sterile outlet

in the basics of the cycle, he is carried away by the whirlwind that recognizes it. Β

The result of multiple collisions of particles is a cyclone and

Partial destruction of agglomerates of particles occurs between themselves and

A generatable fraction coming out of an inhalation is generated

medicinal product.

On the other hand, and with such a combination of inhalation, partly

Particle parts of a medicinal product are not

Disintegrated in the dispersion, or stays in it, or falls into disrepair

SIGNIFICANT FOX (DR. 26)

aerosol and seated in the mouth, which can cause a number of undesirable

PERSONAL EFFECTS

The closest proposed device is the ishalat for

the introduction of medicinal products in the form of a powder [6], which is convenient

remove the particulate particles from the produced air supply and

It contains a compartment with requirements for entering the air and leaving the airport,

connected to the air, a distributor was installed in the drive. Β

In addition, a container is installed for medical treatment and delivery, and

ALSO CAPACITY FOR DISPOSAL OF GROUP DISPERSION PARTICLES, DISPERSION

made in the form of a cylindrical camera with a tangentially mounted

at its first base of the device and installed

output section deepened into a cylindrical camera, and the tank

for disassembling group particles, it is communicated with a cylindrical camera

By means of a slotted hole made at its base.

However, the above inhalation [6] is not universal and does not

Possesses some convenient for its use by customers

the facilities are not economical and ergonomic.

ΡΑСΚΡЫΤИΕ ΕΟΟΡΕΤΕΗΡΕΤΕΗ

With the result of human life, to reach the other direction

The proposed invention is the creation of such a device for

Italizations of medicinal products in the form of a powder, which, having

SIGNIFICANT FOX (DR. 26) Conveniently manufactured and economical in size and

The cost of construction, would have been nice to some, convenient for him

use by users of the assumptions would be

reasonably economical and ergonomic. SUMMARY OF THE INVENTION

directed to the establishment of such a device for inhalation of drugs

assets in the form of a product, which would make it possible to reliably share

UNIVERSAL PARTICULAR PARTICLES AND LARGE AGRICULTURES

LOCAL PRODUCTIVITY FROM RESPONSIBLE FACTION ACTIVE

The component would have an esthetically pleasing appearance

and, if operated, would be technically reliable, protect

PREPARATORY MEDICINAL PRODUCT FOR IMPORTANT IMPURITIES.

The device must be such that it can be operated

DRUG DRUG AND DRY FOR ANY TREATMENT AND ANYONE TRANSPORT AND

Real Estate. Otherwise, device operation

Exclude frequent inhalation inhalation.

The product is achieved by inhalation devices.

medicinal products in the form of a powder, including

inlet, for air inlet and outlet, connected

drive, dispersed in the form of a cylindrical

Cameras with tangentially installed in the base of the input

Patient and fully installed, coming through the same

SIGNIFICANT FOX (DR. 26) 7

Base, outlet, deepened into a cylindrical camera

So that it is located in the entire north direction of the country.

between the input and the second base, the capacity for the sink,

Container disassembling container, communicated with

With a cylindrical camera with a slit hole,

Performed in its lateral position at the second base, the result,

performed with the option of moving the dose to

The drive also includes a multi-purpose, versatile facility

USE, REMOVABLE NOZZLE, INCLUDED INPUT

connecting coupling made from an elastic material for

connecting the nozzle to the drive, the nozzle includes a distributor,

capacity for disassembling subdivisions of particles carried out by

random-disks with a cylindrical camshaft

so that the level of the mixture does not reach the slotted hole

Any convenient extension of the nozzle, and even this device may

to be completed as a unit, as well as external, and the capacity for a unit

GROUP DISPERSAL PARTICLES The product may be made from a distribution unit.

material. The device has a protective case that protects you from

rash and protection against entry contamination for entry

the air inlet and outlet, the outlet is equipped with a mouthpiece and

completed form of a removable block. Иψ and therefore, the connector

SIGNIFICANT FOX PΤIL 26 8

made by a hermetic, or equipped with adjustable

values for securing the accessories of the nozzle and at the same time as

inhalers of any type. DEVICES THANKS TO ITS CONSTRUCTION

It may be from any material.

Devices for inhalation of medicinal products in the form of a powder

Shown in Figure 1 (Figure 1). Fig. 2 (Fig. 2) is provided

multi-purpose universal nozzle, section Α-Α,

section BB. In Figure 3 (Fig. 3), the connection to the universal

nozzles for multiple use with a generous inhaler.

Devices for inhalation of medicinal products in the form of a powder

Includes room 1 with steps 2 and 3, for air inlet and outlet

aerosol, connected to the air 4, dispersion 5, performed

in the form of a cylindrical camera 8 with a tangentially mounted

Base unit with input unit 9 and optionally installed,

If you exit through the same base, exit unit 10,

deepened into a cylindrical camera such that it is

Conclusion in the general direction is between the input unit and

second base, storage space for tank 6, storage tank for dump

PARTY DISPOSAL PARTICLE 12, COMMUNICATED WITH THE PARTY

cylindrical camera with slit hole 11,

SIGNIFICANT FOX PΤIL 26 Performed in its lateral position at the second base, result 7,

performed with the option of moving the dose to

airway. The device additionally includes a universal

multi-use, detachable nozzle 13, input end

It is equipped with a connecting connector 14, made from an elastic

material, to connect the nozzle to the drive, nozzle

many uses include dispersion 5, storage capacity

subdivision of unit 12, performed by a disassembled unit

coaxial with a cylindrical camera so that the level

A good mix does not reach slit hole 11 and any

Industrial nozzle attachment. The device has a protective case

15, protecting the rash of the rash and protecting the rain

Pollution for entering the air and leaving the airport. Βыχοдній

The unit is equipped with a mouthpiece 16 and is made in the form of a removable unit.

Connector 14 Meat was made hermetic.

The connector may also be equipped with accessories 17

Adjustable value for securing the accessory of the nozzle

many uses and in conjunction with inhalants of any kind

τiπa.

Devices for the search for medicinal products in the form of a powder

It works as follows. If you need access to 7 doses, please contact

SIGNIFICANT FOX (DR. 26) 10

mixtures are transferred from tank 6 to air 4. In the process

inhalation of air through inhalation devices, dose of inhalation

the mixture is carried away by the flow, and through the input unit 9, it starts in

a cylindrical camera 8, in which there is an intense vortex

flow. The coming air is moving at a harmless

crashes along the cylindrical lateral camcorder 8 to her

in general knowledge, i.e. at the end of the cylindrical camera, where,

changing the axial component of the velocity by 180 °, in the form of tapering

the wiring harness begins to move to the base of the base and

Launches into the outlet 10.

Carrier particles through the operation of a central force

Comes to the side of the camcorder 8 and carried away by the project

air flows to its second base, forming a larger ring

Concentrated Dispersed Phase Out of Contact

inertia through a slotted opening 11 to an additional capacity of 12 for

collection of group particles. Active Particles Active

Component of the medical unit, separated from the carrier particles,

The end-to-end action of the central military force is carried away by the air

Open the outlet 10 and get into easy care.

OTHER RESPONSE TO OUTPUT PUBLIC UNIT

It is located between the input unit and the second base

SIGNIFICANT FOX (DR. 26) eleven

cylindrical cameras, τ, e. the outlet is in the outlet

Handle that excludes falling into a negative subdistribution of particles

agro-food and foreign carrier as a result

There is a flap of the input wall of the unit and the cylindrical camera. Κροome

Therefore, the convenient use of the outgoing unit allows you to avoid

Crashes into a neglected group of displaced particles as a result of it

accidental rash from an additional capacity.

To improve ergonomic properties, the proposed device

It can be performed as a unit, as well as a unit. Κροме τοгο, for

the convenience of using it by the user, a container for the reset

GROUP DISPERSAL PARTICLES The product may be made from a distribution unit.

material. For convenient transport in the device, please use

a protective cover that protects the rash and protects

There is no pollution for the entrance of the air and the exit of the airport. Βыχοдній

The handset may be equipped with a mouthpiece and may be made as

removable block. The coupling has been made hermetic, either

equipped with adjustable values for maintenance

Accessory nozzles for use with inhalers of any type,

which provides unambiguous benefits for the users of this data.

device.

SIGNIFICANT FOX (DR. 26) 12

The device is universal, but it may be made of

any material.

In general, the proposed device for inhalation of medicinal products is

a product in the form of a powder, having a relatively simple manufacture and

economical volume and cost of ownership, apart from that, which

It reliably separates sub-dispersed particles from foreign sources.

carrier and large agglomerates of the drug store

The active fraction of the active component is comfortable for

USE OF USERS, ACCESSORIES.

The proposed device is quite economical in manufacture and

ergonomically sensitive and natural features, and

Operationally reliable, protects the user-friendly

MEDICINAL PRODUCTS FOR IMPORTANT IMPURITIES. Operations

the device protects the drug from the rash and any

business and industrial development. Τ ο τ τ τ,,,, convenient

The operation of the device excludes the frequent inhalation treatment.

SIGNIFICANT FOX (DR. 26) thirteen

PUSHNY PΡIΡIΜΕΗSΤ

Devices for inhalation of medicinal products in the form of a powder

it is universal and may be manufactured from any material. Various

Types of its constituents are subject to the invention. Experienced

Samples are waiting for quality and reliability of the user-friendly equipment

device. Dealing with such products is possible even on

A relatively small industrial accident. Introduction and Implementation

DEVICES IN SERIAL PRODUCTS ARE SMALL.

CALCULATIONS AND FUNCTIONS:

1. Patent No. 2097069, CL Α 61 Μ 15/00, Bull. Ν ° 33, 1997

2. Patent ΡΦ Μ> 2100035, cl. Α 61 Μ 15/00, Bull. He 36, 1997

3. Patent Л L δ 2014096, κl. Α 61 Μ 15/00, 13/00, Bull. Ν ° C, 1994

4. Patent Ν ° 2014097, cl. Α 61 Μ 15/00, 13/00, Bull. Ν ° 11, 1994

5. Patent ΡΦ Ν ° 2002467, cl. Α 61 Μ 15/00, Bull. ! Ν ° 41-42, 1993

6. Patent ΡΦ ÷ Ν ° 2163149, cl. Α 61 Μ 15/00, Bull. "5, 2001

SIGNIFICANT FOX (DR. 26)

Claims

14

ΦΟΡΜУЛΑ ИБΟБΡΕΤΕΗИЯ

Ι.A device for inhalation of medicinal products in the form of a solution,

inclusive housing with answers for the entrance of the air and the exit of the airport,

connected to the drive, a dispersion made in the form

cylindrical cameras with tangentially mounted at the front

Bases of the input unit and the installed unit,

on the other hand, through the same understanding, on the output side, deepened into

A cylindrical camera such that it is connected to

The main direction is between the input unit and the second one.

Base, container for storage, container for dumping unit

particles of the chamber, which is communicated with the surface of the cylindrical camera

With direct slotted hole made in its side wall at

on the other hand, access made with the possibility of accommodation

doze in the air, which differs in that

Includes universal, multi-use, removable

the nozzle is equipped with a connecting coupling,

made from an elastic material to connect the nozzle to

Inlet, nozzle includes disperse, container for assembly

subdivision of partitioned units carried out by a disassembled unit

inconsequentially with a pan-cam camera, so that is

SIGNIFICANT FOX (DR. 26) fifteen

A good mix does not reach a slit hole without any

Special nozzle orientation.

2. INSTRUMENTS π 1, which is different in that it is performed

popular.

3. The device is π 1, which is different in that it is completed by the unit.

4. DEVICES π 1-3, characterized by the fact that the capacity for the dump

subdivision of particles is carried out from the sales material.

5. Devices of any kind from pp.1-4, which differs in that it has

a protective cover that protects the rash and protects

There is no pollution for the entrance of the air and the exit of the airport.

6. Devices of any kind from ππ. 1-5, characterized by the fact that the output

The unit is equipped with a mouthpiece and is made in the form of a removable unit.

7. Devices of any kind from pp.1-6, differing in that

the connector is made hermetic.

8. Devices of any kind from ππ. 1-6, characterized in that

the connector is equipped with adjustable values for

Providing accessory equipment for inhalation and inhalation

Anything like that.

9. Devices of any kind from ππ. 1-8, characterized in that it was carried out

from any material.

SIGNIFICANT FOX (DR. 26)