WO2003053351A3 - A NOVEL REGULATORY ELEMENT WITHIN THE IL-Iα PROMOTER AND USES THEREOF - Google Patents

A NOVEL REGULATORY ELEMENT WITHIN THE IL-Iα PROMOTER AND USES THEREOF Download PDF

Info

Publication number
WO2003053351A3
WO2003053351A3 PCT/US2002/040134 US0240134W WO03053351A3 WO 2003053351 A3 WO2003053351 A3 WO 2003053351A3 US 0240134 W US0240134 W US 0240134W WO 03053351 A3 WO03053351 A3 WO 03053351A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulatory element
promoter
novel regulatory
aids
cancer
Prior art date
Application number
PCT/US2002/040134
Other languages
French (fr)
Other versions
WO2003053351A2 (en
Inventor
Monique A Berman
Frank Zaldivar
Karen L Imfeld
Original Assignee
Children S Hospital Of Orange
Monique A Berman
Frank Zaldivar
Karen L Imfeld
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Children S Hospital Of Orange, Monique A Berman, Frank Zaldivar, Karen L Imfeld filed Critical Children S Hospital Of Orange
Priority to AU2002360610A priority Critical patent/AU2002360610A1/en
Publication of WO2003053351A2 publication Critical patent/WO2003053351A2/en
Publication of WO2003053351A3 publication Critical patent/WO2003053351A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A novel regulatory element was identified in the promoter of Interleukin 1 alpha (IL-1α) which mediates activation of the promoter and may be involved in the symptoms and pathogenesis of immune and inflammatory diseases as well as cancer and AIDS. A protein which binds to the regulatory element and activates transcription of IL-1α was also identified. The protein and the regulatory element are used to identify and isolate pharmaceuticals which are used to treat immune and inflammatory diseases as well as cancer and AIDS.
PCT/US2002/040134 2001-12-12 2002-12-12 A NOVEL REGULATORY ELEMENT WITHIN THE IL-Iα PROMOTER AND USES THEREOF WO2003053351A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002360610A AU2002360610A1 (en) 2001-12-12 2002-12-12 A novel regulatory element within the il-ialpha promoter and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34034001P 2001-12-12 2001-12-12
US60/340,340 2001-12-12

Publications (2)

Publication Number Publication Date
WO2003053351A2 WO2003053351A2 (en) 2003-07-03
WO2003053351A3 true WO2003053351A3 (en) 2003-12-04

Family

ID=23332926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/040134 WO2003053351A2 (en) 2001-12-12 2002-12-12 A NOVEL REGULATORY ELEMENT WITHIN THE IL-Iα PROMOTER AND USES THEREOF

Country Status (2)

Country Link
AU (1) AU2002360610A1 (en)
WO (1) WO2003053351A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150050250A1 (en) * 2012-04-05 2015-02-19 University Of Southern California Cell therapy technology to deliver radio-protective peptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191269B1 (en) * 1997-05-30 2001-02-20 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
US6358732B1 (en) * 1994-08-26 2002-03-19 Aventis Pharma Deutschland Gmbh DNA for expression under control of a cell cycle-dependent promoter

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358732B1 (en) * 1994-08-26 2002-03-19 Aventis Pharma Deutschland Gmbh DNA for expression under control of a cell cycle-dependent promoter
US6191269B1 (en) * 1997-05-30 2001-02-20 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZALDIVAR ET AL.: "Identification of a novel regulatory element in the human interleukin 1 alpha (IL-1a) gene promoter", CYTOKINE, vol. 20, no. 3, November 2002 (2002-11-01), pages 130 - 135, XP002965525 *

Also Published As

Publication number Publication date
AU2002360610A8 (en) 2003-07-09
AU2002360610A1 (en) 2003-07-09
WO2003053351A2 (en) 2003-07-03

Similar Documents

Publication Publication Date Title
HK1121174A1 (en) Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use
AT500379B1 (en) TAU PROTEINS
WO2003086451A8 (en) Asthma-related anti-il-13 immunoglobulin derived proteins, compositions, methods and uses
AR038568A1 (en) ANTI-A BETA ANTIBODIES AND ITS USE
BRPI0514124A (en) human monoclonal antibodies to human il-4
WO2003045317A3 (en) Therapeutic protein and treatments
WO2003057856A3 (en) Dominant negative proteins and methods thereof
DE60133366D1 (en) IRAQ-4 COMPOSITIONS AND ITS USES
DE50205029D1 (en) INFLAMMATORY PEPTIDES AND THEIR USES
JP2004511492A5 (en)
WO2004065406A3 (en) Rantes-derived peptides with anti-hiv activity
WO2006109045A3 (en) Cathepsin s antibody
WO2003053351A3 (en) A NOVEL REGULATORY ELEMENT WITHIN THE IL-Iα PROMOTER AND USES THEREOF
WO2001064876A3 (en) Human schizophrenia gene
EP2116616A3 (en) Genes differentially expressed in activated T cells and uses thereof
PT723552E (en) OLIGOPEPTIDES DERIVED FROM REAGENT PROTEIN FRAGMENTS
ECSP034872A (en) NEW HETEROCICLOS 3
WO2003048317A3 (en) Antibodies to magmas and uses thereof
WO2005046714A3 (en) Cytokine antagonist molecules
DE60235809D1 (en) NUCLEIC ACID-FREE GHOST COMPOSITIONS
WO2004104574A3 (en) Diagnostics and therapeutics for diseases associated with c-c chemokine receptor type 7 (ccr7)
WO2005011728A3 (en) Use of soluble cd164 in inflammatory and/or autoimmune disorders
WO2001072334A3 (en) Methods for treating disease with antibodies to cxcr3
WO2004041296A3 (en) Pharmaceutical composition comprising a tissue factor antagonist and protein c polypeptides
WO2005023979A3 (en) Isolated s. mansoni nucleic acid molecules and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP