WO2003052053A3 - Bibliotheques nucleosidiques et composes obtenus au moyen de strategies combinatoires mcc realisees sur support solide - Google Patents

Bibliotheques nucleosidiques et composes obtenus au moyen de strategies combinatoires mcc realisees sur support solide Download PDF

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Publication number
WO2003052053A3
WO2003052053A3 PCT/US2002/034025 US0234025W WO03052053A3 WO 2003052053 A3 WO2003052053 A3 WO 2003052053A3 US 0234025 W US0234025 W US 0234025W WO 03052053 A3 WO03052053 A3 WO 03052053A3
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WO
WIPO (PCT)
Prior art keywords
mcc
nucleoside
compounds
libraries
solid support
Prior art date
Application number
PCT/US2002/034025
Other languages
English (en)
Other versions
WO2003052053A2 (fr
Inventor
Zhi Hong
Frank Rong
Haoyun An
Weijian Zhang
Original Assignee
Ribapharm Inc
Zhi Hong
Frank Rong
Haoyun An
Weijian Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribapharm Inc, Zhi Hong, Frank Rong, Haoyun An, Weijian Zhang filed Critical Ribapharm Inc
Priority to AU2002349905A priority Critical patent/AU2002349905A1/en
Publication of WO2003052053A2 publication Critical patent/WO2003052053A2/fr
Publication of WO2003052053A3 publication Critical patent/WO2003052053A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Structural Engineering (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des bibliothèques d'analogues nucléosidiques et des composés contenus dans ces bibliothèques, qui sont préparés selon une approche mettant en oeuvre des bibliothèques combinatoires en phase solide. Dans quelques aspects préférés de l'invention, diverses bases hétérocycliques et/ou divers substituants nucléosidiques sont préparés par condensation à plusieurs constituants (MCC). Dans d'autres aspects préférés de l'invention, la diversité des bibliothèques est obtenue par l'utilisation de nucléosides couplés en phase solide, dans une série d'au moins deux réactions de modification. Des composés particulièrement préférés comprennent des analogues nucléosidiques obtenus par la mise en oeuvre de bibliothèques de l'invention, qui peuvent être utiles pour le traitement de diverses affections, en particulier des infections virales ou des maladies néoplatiques.
PCT/US2002/034025 2001-12-17 2002-10-23 Bibliotheques nucleosidiques et composes obtenus au moyen de strategies combinatoires mcc realisees sur support solide WO2003052053A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002349905A AU2002349905A1 (en) 2001-12-17 2002-10-23 Nucleoside libraries and compounds by mcc combinatorial strategies on solid support

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34233701P 2001-12-17 2001-12-17
US60/342,337 2001-12-17

Publications (2)

Publication Number Publication Date
WO2003052053A2 WO2003052053A2 (fr) 2003-06-26
WO2003052053A3 true WO2003052053A3 (fr) 2004-03-18

Family

ID=23341394

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/034025 WO2003052053A2 (fr) 2001-12-17 2002-10-23 Bibliotheques nucleosidiques et composes obtenus au moyen de strategies combinatoires mcc realisees sur support solide

Country Status (2)

Country Link
AU (1) AU2002349905A1 (fr)
WO (1) WO2003052053A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
CN114404427A (zh) 2014-02-13 2022-04-29 配体药物公司 前药化合物及其用途
US9994600B2 (en) 2014-07-02 2018-06-12 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
EP3737676B1 (fr) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Composés acétal et leurs utilisations thérapeutiques

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996030392A1 (fr) * 1995-03-28 1996-10-03 Novartis Ag Procede de production de bibliotheques combinatoires de composes
US5858670A (en) * 1990-07-02 1999-01-12 The Arizona Board Of Regents Bio-oligomer libraries and a method of use thereof
WO1999034378A1 (fr) * 1997-12-23 1999-07-08 Siemens Aktiengesellschaft Dispositif pour la commande d'un actionneur electromecanique
WO2002090536A2 (fr) * 2001-05-10 2002-11-14 Novozymes A/S Methode de production de polynucleotides recombines
WO2002103012A1 (fr) * 2001-06-15 2002-12-27 Crucell Holland B.V. Phages chimeriques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858670A (en) * 1990-07-02 1999-01-12 The Arizona Board Of Regents Bio-oligomer libraries and a method of use thereof
WO1996030392A1 (fr) * 1995-03-28 1996-10-03 Novartis Ag Procede de production de bibliotheques combinatoires de composes
WO1999034378A1 (fr) * 1997-12-23 1999-07-08 Siemens Aktiengesellschaft Dispositif pour la commande d'un actionneur electromecanique
WO2002090536A2 (fr) * 2001-05-10 2002-11-14 Novozymes A/S Methode de production de polynucleotides recombines
WO2002103012A1 (fr) * 2001-06-15 2002-12-27 Crucell Holland B.V. Phages chimeriques

Also Published As

Publication number Publication date
AU2002349905A1 (en) 2003-06-30
AU2002349905A8 (en) 2003-06-30
WO2003052053A2 (fr) 2003-06-26

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