WO2003050139A2 - Peptides d'inhibition de prion et leurs derives - Google Patents

Peptides d'inhibition de prion et leurs derives Download PDF

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Publication number
WO2003050139A2
WO2003050139A2 PCT/EP2002/013915 EP0213915W WO03050139A2 WO 2003050139 A2 WO2003050139 A2 WO 2003050139A2 EP 0213915 W EP0213915 W EP 0213915W WO 03050139 A2 WO03050139 A2 WO 03050139A2
Authority
WO
WIPO (PCT)
Prior art keywords
derivative
present
peptide
peptides
prp
Prior art date
Application number
PCT/EP2002/013915
Other languages
English (en)
Other versions
WO2003050139A3 (fr
Inventor
Céline Adessi
Serge Halazy
Gabriela Saborio
Claudio Soto-Jara
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Priority to EP02792940A priority Critical patent/EP1481001A2/fr
Priority to US10/497,160 priority patent/US20050181998A1/en
Priority to AU2002358647A priority patent/AU2002358647A1/en
Priority to IL16233302A priority patent/IL162333A0/xx
Priority to JP2003551163A priority patent/JP2005514385A/ja
Priority to CA002467914A priority patent/CA2467914A1/fr
Publication of WO2003050139A2 publication Critical patent/WO2003050139A2/fr
Publication of WO2003050139A3 publication Critical patent/WO2003050139A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention concerne des peptides courts et des dérivés ou analogues de ceux-ci, destinés au traitement ou à la prévention d'encéphalopathies spongiformes transmissibles, en particulier de la maladie de Creutzfeldt-Jacob. Ces peptides et/ou leurs dérivés ont été élaborés pour bloquer les changements de conformations qui touchent la protéine prion (PrP) et qui sont impliqués dans la pathogenèse des encéphalopathies spongiformes transmissibles, et pour dissoudre les dépôts fibrillaires déjà formés.
PCT/EP2002/013915 2001-12-10 2002-12-09 Peptides d'inhibition de prion et leurs derives WO2003050139A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP02792940A EP1481001A2 (fr) 2001-12-10 2002-12-09 Peptides d'inhibition de prion et leurs derives
US10/497,160 US20050181998A1 (en) 2001-12-10 2002-12-09 Prion inhibiting peptides and derivatives thereof
AU2002358647A AU2002358647A1 (en) 2001-12-10 2002-12-09 Prion inhibiting peptides and derivatives thereof
IL16233302A IL162333A0 (en) 2001-12-10 2002-12-09 Peptides inhibiting prions
JP2003551163A JP2005514385A (ja) 2001-12-10 2002-12-09 プリオン阻害ペプチド及びその誘導体
CA002467914A CA2467914A1 (fr) 2001-12-10 2002-12-09 Peptides d'inhibition de prion et leurs derives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01000733 2001-12-10
EP01000733.4 2001-12-10

Publications (2)

Publication Number Publication Date
WO2003050139A2 true WO2003050139A2 (fr) 2003-06-19
WO2003050139A3 WO2003050139A3 (fr) 2003-10-02

Family

ID=8176108

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/013915 WO2003050139A2 (fr) 2001-12-10 2002-12-09 Peptides d'inhibition de prion et leurs derives

Country Status (7)

Country Link
US (1) US20050181998A1 (fr)
EP (1) EP1481001A2 (fr)
JP (1) JP2005514385A (fr)
AU (1) AU2002358647A1 (fr)
CA (1) CA2467914A1 (fr)
IL (1) IL162333A0 (fr)
WO (1) WO2003050139A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7439041B2 (en) 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US7834144B2 (en) 2005-09-09 2010-11-16 Novartis Ag Prion-specific peptoid reagents

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (fr) * 2001-05-31 2013-02-27 Adlyfe, Inc. Procede de detection de proteines mal pliees
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP5048522B2 (ja) * 2005-02-15 2012-10-17 エイディーライフ インコーポレイティッド 誤って折り畳まれたタンパク質およびプリオンを検出する方法
US8673579B2 (en) * 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
CA2619157A1 (fr) * 2007-02-08 2008-08-08 Michel Serrano Composition contre le papillomavirus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THOMSON A ET AL: "THE SPECIFICITY OF THE S-1 AND S-2 SUBSITES OF ELASTASE EC-3.4.21.11" EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 102, no. 1, 1979, pages 111-116, XP001062191 ISSN: 0014-2956 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7439041B2 (en) 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US7834144B2 (en) 2005-09-09 2010-11-16 Novartis Ag Prion-specific peptoid reagents

Also Published As

Publication number Publication date
WO2003050139A3 (fr) 2003-10-02
EP1481001A2 (fr) 2004-12-01
CA2467914A1 (fr) 2003-06-19
AU2002358647A1 (en) 2003-06-23
JP2005514385A (ja) 2005-05-19
IL162333A0 (en) 2005-11-20
US20050181998A1 (en) 2005-08-18

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