WO2003045498A1 - Machine de thermotherapie a ultrasons et procede de prevision de la temperature de foyer - Google Patents
Machine de thermotherapie a ultrasons et procede de prevision de la temperature de foyer Download PDFInfo
- Publication number
- WO2003045498A1 WO2003045498A1 PCT/CN2002/000165 CN0200165W WO03045498A1 WO 2003045498 A1 WO2003045498 A1 WO 2003045498A1 CN 0200165 W CN0200165 W CN 0200165W WO 03045498 A1 WO03045498 A1 WO 03045498A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- temperature
- focus
- wave source
- comparison table
- theoretical
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
Definitions
- the invention relates to a medical device for killing a diseased tissue by utilizing the effect of a high-energy focused ultrasonic wave emitted from a patient's external ultrasound (HIFU) wave source, and specifically relates to an ultrasonic hyperthermia machine and a method for predicting a focal temperature thereof.
- HIFU external ultrasound
- HIFU treatment device is one of the hot spots in medical research at home and abroad, and the clinical application has obtained good results.
- Practical external HIFU hyperthermia machines generally consist of the following parts:
- High-energy focused ultrasound source and driving circuit are used to generate high-energy focused ultrasound waves.
- Positioning system one by one is used to find the treatment target and move it to the focal point of the ultrasonic transducer. It includes a medical imaging system (mostly a B ultrasound machine), a patient-carrying device (such as a bed surface), and a displacement system that spatially moves the device relative to the wave source.
- a medical imaging system mostly a B ultrasound machine
- a patient-carrying device such as a bed surface
- a displacement system that spatially moves the device relative to the wave source.
- High-energy ultrasonic conductive structure and conductive medium processing system-Since the ultrasonic waves applicable to HIFU must be introduced into the patient's body through a special conductive medium (multi-purpose degassed water), there must be a Structures that contain conductive media (such as water tanks, leeches, etc.), and devices that add and discharge conductive media and process the media.
- a special conductive medium multi-purpose degassed water
- conductive media such as water tanks, leeches, etc.
- thermotherapy machine the most direct method to obtain the temperature at the focal point of the thermotherapy machine is physical measurement, which is divided into two types: non-destructive temperature measurement and non-destructive temperature measurement:
- Non-destructive temperature measurement is relatively simple, in which a temperature sensor is directly inserted into the human body to obtain the temperature at the focal point. Since it is directly measured, the focal point can be accurately obtained temperature.
- this method requires the temperature sensor to be inserted into the human body, this not only causes patient pain, but also brings wound infection, so direct physical measurement methods are difficult to apply to the actual treatment of the hyperthermia machine.
- Nondestructive temperature measurement is a method that directly obtains the temperature in the human body without causing physical harm to the human body. There are many principles of nondestructive temperature measurement, such as CT and ultrasound, but they are currently in the theoretical research stage.
- the purpose of the present invention is to provide a hyperthermia machine which can avoid the use of destructive temperature measurement to a patient and can obtain the focus temperature more accurately, and a method for predicting the focus temperature thereof, wherein the temperature at the focus is predicted by computer simulation calculation.
- the ultrasonic thermotherapy machine of the present invention includes: a high-energy focused ultrasound source, a B-ultrasound probe installed inside the wave source, a computer, and a console, wherein: the computer includes an input for inputting treatment parameters A unit, a focus temperature query unit connected to the input unit for querying the corrected temperature comparison table to obtain the focus temperature according to the input parameters, and an output unit for outputting the focus temperature.
- the method for predicting the focus temperature of the thermotherapy machine includes the following steps: inputting a treatment parameter to a focus temperature query unit through an input unit; and according to the input condition, the focus temperature query unit queries the stored corrected focus temperature comparison The table obtains the focus temperature; and outputs the focus temperature through an output unit.
- the present invention Since the present invention does not need to directly measure the temperature at the focal point, the present invention is free of In addition to the patient's pain caused by inserting the temperature sensor into the human body, there is no problem of wound infection. In addition, it also overcomes the problem of large arbitrariness in the selection of treatment parameters in the prior art hyperthermia machines. Since the principle of the hyperthermia machine is to kill the tumor cells by using the high temperature generated by ultrasound focusing, therefore, in practice, using this hyperthermia machine and its temperature measurement method, doctors can adjust the treatment parameters according to the focus temperature provided by the invention In order to ensure that the focus has a sufficiently high temperature, this improves the actual treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS
- FIG. 1 is a structural barrel diagram of a hyperthermia machine according to the present invention
- FIG. 2 is a main configuration diagram of a computer of a hyperthermia machine according to the present invention.
- FIG. 3 is a diagram used in the calculation of the sound intensity of a wafer used in the present invention.
- FIG. 4 is a diagram used in the calculation of the sound intensity of the wave source of the present invention.
- FIG. 6 is a schematic diagram for calculating a corrected temperature comparison table according to the present invention.
- FIG. 7 is a schematic diagram of a method for predicting a focal temperature of a hyperthermia machine according to the present invention. detailed description
- reference numeral 1 is the console of the hyperthermia machine
- reference numeral 2 is the computer on the console
- reference numeral 3 is the B-ultrasound display
- reference numeral 12 is the bed surface of the treatment bed for carrying the patient
- a mechanism for displacement in both horizontal and vertical directions reference numeral 9 is a high-energy focused ultrasonic source
- reference numeral 7 is a B-ultrasound probe installed inside the wave source
- reference numerals 6 and 8 respectively drive the B-ultrasound probe to rotate and lift in the wave source.
- the computer of the present invention will be described in detail below.
- the computer of the thermotherapy machine of the present invention has a function for predicting a focus temperature, and its main structure is shown in FIG. 2, which mainly includes an input unit 21, a focus temperature query unit, and an output unit 22.
- An input unit (such as a keyboard) is used to enter treatment parameters.
- the focus temperature query unit 23 is connected to the input unit for querying the corrected temperature comparison table according to the input parameters to output the focus temperature.
- the output unit may be a display or other well-known output device for outputting (or displaying) the focus temperature queried by the focus temperature query unit.
- the treatment parameters are input through an input unit (such as a keyboard), and the parameters may be parameters that directly affect the temperature at the focal point, such as: input electric power, transmitter conversion efficiency, transmission parameters, tissue characteristics, target skin distance, and wave source characteristics.
- the transmission parameters include: transmission time, interval time, and number of single-point transmissions.
- the characteristics of the wave source include: the radius of the disc, the start and end angles of the wave source distribution, and the number of discs. Since a wave source is used in actual use, the wave source parameters and the conversion efficiency of the transmitter are fixed. Then execute the following algorithm:
- the algorithm mainly consists of two parts: the calculation of the sound field distribution of the wave source and the calculation of the temperature field distribution.
- the surface of the wafer is divided into an infinite number of small facets. Every small facet It can be regarded as a point source.
- the sound pressure generated by the surface element at the observation point P is: dp:) ⁇ u a dS ⁇
- the entire wave source is composed of 300-500 small discs. According to the principle of acoustic wave superposition, the field strength at any point in time is the superposition of these hundreds of small discs.
- the sound intensity of any small disc in space can be determined by ( 3), as shown in FIG. 4.
- the small discs are uniformly distributed on a sphere with a radius R, the initial distribution angle is ⁇ 1, the end distribution angle is ⁇ 2, and the total number of discs is N.
- the wave source parameters are as follows:
- the heat conduction equation in the tissue is (assuming that the biological tissue is isotropic):
- p, C, and K are the effective density, specific heat, and thermal conductivity of the human tissue
- Wb and Cb are the blood flow rate and the specific heat of the blood flow
- Tb is the blood temperature entering the heating zone
- T is the tissue temperature
- Qm Qv is the volumetric heat source brought by the conversion of acoustic energy, which is the heat generation rate of biological metabolism.
- T 0 ⁇ T b Q (W h0 C b )
- FIG. 5 shows a flowchart of the above-mentioned calculation of the theoretical focus temperature.
- the theoretical calculation module by changing parameters such as input electric power, emission parameters, tissue characteristics, and target skin pitch, the above method is used to obtain the theoretical focus temperature under different conditions.
- liver From 600w to launch time, it is divided into: liver, pancreas, from 50mm to
- interval lOOw break time from 150ms bladder, rectum, front 130 mm, interval 10
- FIG. 6 and FIG. 7 respectively show a flowchart of calculating the corrected temperature comparison table and a schematic diagram of predicting a focus temperature.
- the doctor inputs the treatment parameters into the computer; the computer output calculates the sound field distribution and temperature field of the patient through the focus temperature query unit; the doctor can adjust according to the calculation results
- the treatment parameters are re-checked and calculated until the results meet the expectations. After the treatment parameters are selected, the doctor starts the treatment.
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002242588A AU2002242588A1 (en) | 2001-11-28 | 2002-03-15 | An ultrasonic heat therapeutic machine and a predicting method of focus's temperature |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011397160A CN1160136C (zh) | 2001-11-28 | 2001-11-28 | 超声波热疗机及其焦点温度的预测方法 |
CN01139716.0 | 2001-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003045498A1 true WO2003045498A1 (fr) | 2003-06-05 |
Family
ID=4675358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2002/000165 WO2003045498A1 (fr) | 2001-11-28 | 2002-03-15 | Machine de thermotherapie a ultrasons et procede de prevision de la temperature de foyer |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN1160136C (zh) |
AU (1) | AU2002242588A1 (zh) |
WO (1) | WO2003045498A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100401975C (zh) * | 2004-06-04 | 2008-07-16 | 北京源德生物医学工程有限公司 | 超声反演法测量人或动物体内的温度 |
WO2010033940A1 (en) * | 2008-09-22 | 2010-03-25 | Minnow Medical, Inc | Inducing desirable temperature effects on body tissue using alternate energy sources |
CN102284136B (zh) * | 2011-05-11 | 2014-06-25 | 常州瑞神安医疗器械有限公司 | 一种用于植入式医疗仪器的体外程控设备 |
EP2638932A1 (en) * | 2012-03-14 | 2013-09-18 | Theraclion | Device for therapeutic treatment and method for controlling a treatment device |
CN109960293B (zh) * | 2017-12-26 | 2021-07-20 | 深圳先进技术研究院 | 一种热疗的温度控制方法、装置及系统 |
CN109999376B (zh) * | 2019-03-19 | 2021-06-29 | 深圳市声科生物医学研究院 | 一种hifu设备控制系统及其无损测温方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0468847A1 (fr) * | 1990-07-23 | 1992-01-29 | Edap International | Appareil d'hyperthermie ultrasonore extracorporelle ultrarapide |
US5558092A (en) * | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
CN1265929A (zh) * | 1999-03-09 | 2000-09-13 | 北京贝仪医疗设备厂 | 高能超声体外聚焦热疗机功率超声发射器 |
-
2001
- 2001-11-28 CN CNB011397160A patent/CN1160136C/zh not_active Expired - Lifetime
-
2002
- 2002-03-15 AU AU2002242588A patent/AU2002242588A1/en not_active Abandoned
- 2002-03-15 WO PCT/CN2002/000165 patent/WO2003045498A1/zh not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0468847A1 (fr) * | 1990-07-23 | 1992-01-29 | Edap International | Appareil d'hyperthermie ultrasonore extracorporelle ultrarapide |
US5558092A (en) * | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
CN1265929A (zh) * | 1999-03-09 | 2000-09-13 | 北京贝仪医疗设备厂 | 高能超声体外聚焦热疗机功率超声发射器 |
Also Published As
Publication number | Publication date |
---|---|
CN1358549A (zh) | 2002-07-17 |
CN1160136C (zh) | 2004-08-04 |
AU2002242588A1 (en) | 2003-06-10 |
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