WO2003042379A3 - A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide - Google Patents

A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide Download PDF

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Publication number
WO2003042379A3
WO2003042379A3 PCT/EP2002/012534 EP0212534W WO03042379A3 WO 2003042379 A3 WO2003042379 A3 WO 2003042379A3 EP 0212534 W EP0212534 W EP 0212534W WO 03042379 A3 WO03042379 A3 WO 03042379A3
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WO
WIPO (PCT)
Prior art keywords
new
disintegrin
metalloproteinase
polynucleotide
repeats
Prior art date
Application number
PCT/EP2002/012534
Other languages
French (fr)
Other versions
WO2003042379A2 (en
Inventor
Alain Colige
Charles-Maurice Lapiere
Berthe Nusgens
Original Assignee
Univ Liege
Alain Colige
Charles-Maurice Lapiere
Berthe Nusgens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Liege, Alain Colige, Charles-Maurice Lapiere, Berthe Nusgens filed Critical Univ Liege
Priority to AU2002351945A priority Critical patent/AU2002351945A1/en
Publication of WO2003042379A2 publication Critical patent/WO2003042379A2/en
Publication of WO2003042379A3 publication Critical patent/WO2003042379A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention is related to a new isolated and purified polynucleotide sequence that encodes an ADAMTS polypeptide, to said polypeptide, to the various pharmaceutical and industrial applications.
PCT/EP2002/012534 2001-11-13 2002-11-08 A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide WO2003042379A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002351945A AU2002351945A1 (en) 2001-11-13 2002-11-08 A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01204335 2001-11-13
EP01204335.2 2001-11-13

Publications (2)

Publication Number Publication Date
WO2003042379A2 WO2003042379A2 (en) 2003-05-22
WO2003042379A3 true WO2003042379A3 (en) 2004-02-19

Family

ID=8181229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/012534 WO2003042379A2 (en) 2001-11-13 2002-11-08 A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide

Country Status (2)

Country Link
AU (1) AU2002351945A1 (en)
WO (1) WO2003042379A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101283106A (en) * 2005-07-27 2008-10-08 肿瘤疗法科学股份有限公司 Method of diagnosing small cell lung cancer
EP4413134A1 (en) 2021-10-08 2024-08-14 Boehringer Ingelheim International GmbH Adamts14 inhibition

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001059133A1 (en) * 2000-02-14 2001-08-16 Merck Patent Gmbh Larynx carcinoma-associated protein larcap-1
WO2001083782A2 (en) * 2000-05-04 2001-11-08 Sugen, Inc. Novel proteases
WO2001098468A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases
WO2002010216A2 (en) * 2000-07-28 2002-02-07 Curagen Corporation Proteins and nucleic acids encoding same
WO2002016564A2 (en) * 2000-08-22 2002-02-28 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
WO2002024927A2 (en) * 2000-09-20 2002-03-28 Bayer Aktiengesellschaft Regulation of human adam-ts 1 precursor-like protein
WO2002051995A1 (en) * 2000-12-22 2002-07-04 Millennium Pharmaceuticals, Inc. A human metallo protease member of the adamts family, and uses thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001059133A1 (en) * 2000-02-14 2001-08-16 Merck Patent Gmbh Larynx carcinoma-associated protein larcap-1
WO2001083782A2 (en) * 2000-05-04 2001-11-08 Sugen, Inc. Novel proteases
WO2001098468A2 (en) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases
WO2002010216A2 (en) * 2000-07-28 2002-02-07 Curagen Corporation Proteins and nucleic acids encoding same
WO2002016564A2 (en) * 2000-08-22 2002-02-28 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
WO2002024927A2 (en) * 2000-09-20 2002-03-28 Bayer Aktiengesellschaft Regulation of human adam-ts 1 precursor-like protein
WO2002051995A1 (en) * 2000-12-22 2002-07-04 Millennium Pharmaceuticals, Inc. A human metallo protease member of the adamts family, and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOLZ^A^1 H ET AL: "Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family", BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1522, no. 3, 30 December 2001 (2001-12-30), pages 221 - 225, XP004331262, ISSN: 0167-4781 *
CAL S ET AL: "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 283, no. 1-2, 23 January 2002 (2002-01-23), pages 49 - 62, XP004339892, ISSN: 0378-1119 *
COLIGE A ET AL: "HUMAN EHLERS-DANLOS SYNDROME TYPE VII C AND BOVINE DERMATOSPARAXIS ARE CAUSED BY MUTATIONS IN THE PROCOLLAGEN I N-PROTEINASE GENE", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 65, 1999, pages 308 - 317, XP002950308, ISSN: 0002-9297 *
COLIGE ALAIN ET AL: "Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 8, 22 February 2002 (2002-02-22), February 22, 2002, pages 5756 - 5766, XP002237830, ISSN: 0021-9258 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES VII. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICHCAN CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 4, no. 2, 1997, pages 141 - 150, XP001052821, ISSN: 1340-2838 *
PROCKOP D J ET AL: "PROCOLLAGEN N-PROTEINASE AND PROCOLLAGEN C-PROTEINASE TWO UNUSUAL METALLOPROTEINASES THAT ARE ESSENTIAL FOR PROCOLLAGEN PROCESSING PROBABLY HAVE IMPORTANT ROLES IN DEVELOPMENT AND CELL SIGNALING", MATRIX BIOLOGY, XX, XX, vol. 16, no. 7, 1997, pages 399 - 408, XP001042352 *

Also Published As

Publication number Publication date
AU2002351945A1 (en) 2003-05-26
WO2003042379A2 (en) 2003-05-22

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