WO2003042238A3 - Estrogen induced transcription modulating protein met - Google Patents

Estrogen induced transcription modulating protein met Download PDF

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Publication number
WO2003042238A3
WO2003042238A3 PCT/GB2002/005114 GB0205114W WO03042238A3 WO 2003042238 A3 WO2003042238 A3 WO 2003042238A3 GB 0205114 W GB0205114 W GB 0205114W WO 03042238 A3 WO03042238 A3 WO 03042238A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid fragment
saf
protein containing
isolated nucleic
Prior art date
Application number
PCT/GB2002/005114
Other languages
French (fr)
Other versions
WO2003042238A2 (en
Inventor
Jonathan Harold Tobias
Shane Michael Colley
Original Assignee
Univ Bristol
Jonathan Harold Tobias
Shane Michael Colley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bristol, Jonathan Harold Tobias, Shane Michael Colley filed Critical Univ Bristol
Priority to AU2002339148A priority Critical patent/AU2002339148A1/en
Publication of WO2003042238A2 publication Critical patent/WO2003042238A2/en
Publication of WO2003042238A3 publication Critical patent/WO2003042238A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

An estrogen induced transcription modulatory compound is described. The compound comprises a nucleic acid fragment which is selected from (a) an isolated nucleic acid fragment which encodes a protein containing a SAF Box DNA binding motif and an RNA binding domain; (b) an isolated nucleic acid fragment which hybridises to the isolated nucleic acid fragment of (a) above and which encodes a protein containing a SAF Box DNA binding motif and an RNA binding domain; (c) an isolated nucleic acid fragment differing from fragments of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a protein containing a SAF Box DNA binding motif and an RNA binding domain. Preferably the nucleic acid fragment is a DNA molecule. The nucleic acid fragment codes for a protein containing a SAF Box DNA binding motif and an RNA binding domain.
PCT/GB2002/005114 2001-11-12 2002-11-11 Estrogen induced transcription modulating protein met WO2003042238A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002339148A AU2002339148A1 (en) 2001-11-12 2002-11-11 Estrogen induced transcription modulating protein met

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0127217.8A GB0127217D0 (en) 2001-11-12 2001-11-12 MET a novel suppresser of estrogen induced transcription
GB0127217.8 2001-11-12

Publications (2)

Publication Number Publication Date
WO2003042238A2 WO2003042238A2 (en) 2003-05-22
WO2003042238A3 true WO2003042238A3 (en) 2003-10-16

Family

ID=9925681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/005114 WO2003042238A2 (en) 2001-11-12 2002-11-11 Estrogen induced transcription modulating protein met

Country Status (3)

Country Link
AU (1) AU2002339148A1 (en)
GB (1) GB0127217D0 (en)
WO (1) WO2003042238A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029221A2 (en) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Proteins and polynucleotides encoding them
WO2001063292A2 (en) * 2000-02-22 2001-08-30 Board Of Regents, The University Of Texas System Compositions and methods of use of het, a novel modulator of estrogen action

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029221A2 (en) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Proteins and polynucleotides encoding them
WO2001063292A2 (en) * 2000-02-22 2001-08-30 Board Of Regents, The University Of Texas System Compositions and methods of use of het, a novel modulator of estrogen action

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
OESTERREICH S ET AL: "TAMOXIFEN-BOUND ESTROEN RECEPTOR (ER) STRONGLY INTERACTS WITH THE NUCLEAR MATRIX PROTEIN HET/SAF-B, A NOVEL INHIBITOR OF ER-MEDIATED TRANSACTIVATION", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 14, no. 3, March 2000 (2000-03-01), pages 369 - 381, XP001034970, ISSN: 0888-8809 *
OESTERREICHER S ET AL: "Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells", JOURNAL OF CELLULAR BIOCHEMISTRY, WILEY-LISS INC, US, vol. 67, no. 2, 1 November 1997 (1997-11-01), pages 275 - 286, XP002097726, ISSN: 0730-2312 *
RENZ ANDREA ET AL: "Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA.", NUCLEIC ACIDS RESEARCH, vol. 24, no. 5, 1996, pages 843 - 849, XP002249579, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
WO2003042238A2 (en) 2003-05-22
GB0127217D0 (en) 2002-01-02
AU2002339148A1 (en) 2003-05-26

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