WO2003040100A1 - Compositions, methods and kits pertaining to luminescent compounds - Google Patents
Compositions, methods and kits pertaining to luminescent compounds Download PDFInfo
- Publication number
- WO2003040100A1 WO2003040100A1 PCT/US2002/034972 US0234972W WO03040100A1 WO 2003040100 A1 WO2003040100 A1 WO 2003040100A1 US 0234972 W US0234972 W US 0234972W WO 03040100 A1 WO03040100 A1 WO 03040100A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- heteroalkyl
- alkyl
- enzyme
- group
- Prior art date
Links
- DAACCLRNUQVTEQ-UHFFFAOYSA-N CC(O)Oc1ccc(Cc(nc2[n]3cc(-c(cc4)ccc4OC(C)=O)nc2Cc2ccccc2)c3OC(C)=O)cc1 Chemical compound CC(O)Oc1ccc(Cc(nc2[n]3cc(-c(cc4)ccc4OC(C)=O)nc2Cc2ccccc2)c3OC(C)=O)cc1 DAACCLRNUQVTEQ-UHFFFAOYSA-N 0.000 description 1
- QQEYFVVBWCPVRU-UHFFFAOYSA-N Nc(cc1)ccc1C1=CN(C(C(Cc(cc2)ccc2O)=N2)=O)C2=C(Cc2ccccc2)N1 Chemical compound Nc(cc1)ccc1C1=CN(C(C(Cc(cc2)ccc2O)=N2)=O)C2=C(Cc2ccccc2)N1 QQEYFVVBWCPVRU-UHFFFAOYSA-N 0.000 description 1
- MWOYPGFRXPPBOX-UHFFFAOYSA-N O=C(C(Cc1ccccc1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 Chemical compound O=C(C(Cc1ccccc1)=N1)N2C1=C(Cc1ccccc1)NC(c1ccccc1)=C2 MWOYPGFRXPPBOX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02802815A EP1451155B1 (en) | 2001-11-02 | 2002-11-01 | Compositions, methods and kits pertaining to luminescent compounds |
DE60227408T DE60227408D1 (en) | 2001-11-02 | 2002-11-01 | CONCERNING ORNAMENTAL CONNECTIONS |
DK02802815T DK1451155T3 (en) | 2001-11-02 | 2002-11-01 | Compositions, methods and kits for luminescent compounds |
JP2003542146A JP4958388B2 (en) | 2001-11-02 | 2002-11-01 | Composition, method and kit for luminescent compounds |
CA2462506A CA2462506C (en) | 2001-11-02 | 2002-11-01 | Compositions, methods and kits pertaining to luminescent compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/053,482 | 2001-11-02 | ||
US10/053,482 US7268229B2 (en) | 2001-11-02 | 2001-11-02 | Compounds to co-localize luminophores with luminescent proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003040100A1 true WO2003040100A1 (en) | 2003-05-15 |
Family
ID=21984572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/034972 WO2003040100A1 (en) | 2001-11-02 | 2002-11-01 | Compositions, methods and kits pertaining to luminescent compounds |
Country Status (10)
Country | Link |
---|---|
US (2) | US7268229B2 (en) |
EP (2) | EP1894933B1 (en) |
JP (1) | JP4958388B2 (en) |
CN (2) | CN100439338C (en) |
AT (1) | ATE399784T1 (en) |
CA (1) | CA2462506C (en) |
DE (1) | DE60227408D1 (en) |
DK (1) | DK1451155T3 (en) |
ES (1) | ES2307829T3 (en) |
WO (1) | WO2003040100A1 (en) |
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EP1546162A2 (en) * | 2002-09-20 | 2005-06-29 | Promega Corporation | Luminescence-based methods and probes for measuring cytochrome p450 activity |
US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
US7951550B2 (en) | 2005-05-31 | 2011-05-31 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
WO2012061530A2 (en) | 2010-11-02 | 2012-05-10 | Promega Corporation | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use |
WO2012061477A1 (en) | 2010-11-02 | 2012-05-10 | Promega Corporation | Coelenterazine derivatives and methods of using same |
US8183007B2 (en) | 2008-07-22 | 2012-05-22 | Promega Corporation | ADP detection based methods using adenylate cyclase and bioluminescence |
US8288559B2 (en) | 2008-08-18 | 2012-10-16 | Promega Corporation | Luminogenic compounds and methods to detect cytochrome P450 3A enzymes |
US8557970B2 (en) | 2009-05-01 | 2013-10-15 | Promega Corporation | Synthetic Oplophorus luciferases with enhanced light output |
US8883432B2 (en) | 2010-04-06 | 2014-11-11 | Jnc Corporation | Coelenterazine analogues and coelenteramide analogues |
WO2015116867A1 (en) | 2014-01-29 | 2015-08-06 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
US9273343B2 (en) | 2011-09-02 | 2016-03-01 | Promega Corporation | Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H |
USRE46199E1 (en) | 2006-10-24 | 2016-11-08 | Gene Stream Pty Ltd. | Luciferase signal enhancing compositions |
US9506104B2 (en) | 2013-02-28 | 2016-11-29 | Jnc Corporation | Codon-optimized gene for mutated shrimp luciferase and method for use thereof |
WO2016210294A1 (en) | 2015-06-25 | 2016-12-29 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
US9567623B2 (en) | 2013-04-08 | 2017-02-14 | Jnc Corporation | Coelenterazine analogs |
US9574224B2 (en) | 2013-12-26 | 2017-02-21 | Jnc Corporation | Mutated genes for the catalytic protein of Oplophorus luciferase and use thereof |
US9677117B2 (en) | 2014-10-08 | 2017-06-13 | Promega Corporation | Bioluminescent succinate detection assay |
US9924073B2 (en) | 2016-02-15 | 2018-03-20 | Promega Corporation | Substituted imidazo[1,2-a]pyrazines as luciferase substrates and preparation method thereof |
US9927430B2 (en) | 2014-01-29 | 2018-03-27 | Promega Corporation | Pro-substrates for live cell applications |
US9957487B2 (en) | 2013-10-21 | 2018-05-01 | Jnc Corporation | Mutated genes for the catalytic protein of Oplophorus luciferase and use thereof |
WO2018125992A1 (en) | 2016-12-28 | 2018-07-05 | Promega Corporation | Functionalized nanoluc inhibitors |
WO2019010094A1 (en) * | 2017-07-06 | 2019-01-10 | Promega Corporation | Serum stable pro-coelenterazine analogues |
US10280447B2 (en) | 2016-11-01 | 2019-05-07 | Promega Corporation | Substituted imidazo[1,2-A]pyrazines tethered to energy acceptors |
US10316070B2 (en) | 2016-09-09 | 2019-06-11 | Promega Corporation | Dual protected pro-coelenterazine substrates |
US10377995B2 (en) | 2014-04-16 | 2019-08-13 | Jnc Corporation | Mutated genes for the catalytic protein of Oplophorus luciferase and use thereof |
WO2019213119A1 (en) | 2018-05-01 | 2019-11-07 | Promega Corporation | Coelenterazine compounds as nanoluc suicide substrates |
WO2019232384A1 (en) | 2018-06-01 | 2019-12-05 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
WO2020023871A1 (en) | 2018-07-27 | 2020-01-30 | Promega Corporation | Quinone-containing conjugates |
US10577370B2 (en) | 2016-12-01 | 2020-03-03 | Promega Corporation | Cell impermeable coelenterazine analogues |
WO2020072775A2 (en) | 2018-10-03 | 2020-04-09 | Promega Corporation | Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof |
WO2021108765A1 (en) | 2019-11-27 | 2021-06-03 | Promega Corporation | Multipartite luciferase peptides and polypeptides |
WO2021119149A1 (en) | 2019-12-10 | 2021-06-17 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
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WO2023215514A2 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Bioluminescence-triggered photocatalytic labeling |
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JP2007081050A (en) * | 2005-09-13 | 2007-03-29 | Fujifilm Corp | Organic electroluminescence element |
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2001
- 2001-11-02 US US10/053,482 patent/US7268229B2/en not_active Expired - Lifetime
-
2002
- 2002-11-01 CA CA2462506A patent/CA2462506C/en not_active Expired - Fee Related
- 2002-11-01 ES ES02802815T patent/ES2307829T3/en not_active Expired - Lifetime
- 2002-11-01 WO PCT/US2002/034972 patent/WO2003040100A1/en active Application Filing
- 2002-11-01 CN CNB028266773A patent/CN100439338C/en not_active Expired - Fee Related
- 2002-11-01 JP JP2003542146A patent/JP4958388B2/en not_active Expired - Lifetime
- 2002-11-01 EP EP07025040.2A patent/EP1894933B1/en not_active Expired - Lifetime
- 2002-11-01 EP EP02802815A patent/EP1451155B1/en not_active Expired - Lifetime
- 2002-11-01 AT AT02802815T patent/ATE399784T1/en not_active IP Right Cessation
- 2002-11-01 DE DE60227408T patent/DE60227408D1/en not_active Expired - Lifetime
- 2002-11-01 DK DK02802815T patent/DK1451155T3/en active
- 2002-11-01 CN CNA2008101694033A patent/CN101440089A/en active Pending
-
2007
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US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
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US8802411B2 (en) | 2008-07-22 | 2014-08-12 | Promega Corporation | ADP detection based luminescent phosphotransferase or ATP hydrolase assay |
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EP1894933A2 (en) | 2008-03-05 |
CN100439338C (en) | 2008-12-03 |
ATE399784T1 (en) | 2008-07-15 |
DK1451155T3 (en) | 2008-11-10 |
US7537912B2 (en) | 2009-05-26 |
JP2005515977A (en) | 2005-06-02 |
ES2307829T3 (en) | 2008-12-01 |
CA2462506C (en) | 2010-04-06 |
EP1894933B1 (en) | 2013-07-03 |
EP1451155B1 (en) | 2008-07-02 |
US7268229B2 (en) | 2007-09-11 |
JP4958388B2 (en) | 2012-06-20 |
EP1894933A3 (en) | 2008-03-26 |
EP1451155A1 (en) | 2004-09-01 |
US20030153090A1 (en) | 2003-08-14 |
CA2462506A1 (en) | 2003-05-15 |
CN1612860A (en) | 2005-05-04 |
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EP1451155A4 (en) | 2006-03-01 |
US20080050760A1 (en) | 2008-02-28 |
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