WO2003036298A3 - Closed substrate platforms suitable for analysis of biomolecules - Google Patents

Closed substrate platforms suitable for analysis of biomolecules Download PDF

Info

Publication number
WO2003036298A3
WO2003036298A3 PCT/IB2002/004726 IB0204726W WO03036298A3 WO 2003036298 A3 WO2003036298 A3 WO 2003036298A3 IB 0204726 W IB0204726 W IB 0204726W WO 03036298 A3 WO03036298 A3 WO 03036298A3
Authority
WO
WIPO (PCT)
Prior art keywords
analysis
container
biomolecules
sample analysis
closed substrate
Prior art date
Application number
PCT/IB2002/004726
Other languages
French (fr)
Other versions
WO2003036298A2 (en
Inventor
Mikkel Norholm
Soren Moller
Lars Kongsbak
Mogens Havsteen Jakobsen
Original Assignee
Exiqon As
Mikkel Norholm
Soren Moller
Lars Kongsbak
Mogens Havsteen Jakobsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2001/002902 external-priority patent/WO2002097398A2/en
Priority claimed from US10/057,841 external-priority patent/US20030138969A1/en
Application filed by Exiqon As, Mikkel Norholm, Soren Moller, Lars Kongsbak, Mogens Havsteen Jakobsen filed Critical Exiqon As
Priority to AU2002348982A priority Critical patent/AU2002348982A1/en
Publication of WO2003036298A2 publication Critical patent/WO2003036298A2/en
Publication of WO2003036298A3 publication Critical patent/WO2003036298A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a closed substrate platform comprising: a container comprising an area for sample analysis and a microfluidic analysis platform, the container comprising (i) at least one inlet for the introduction of fluid to the sample analysis area and (ii) an outlet for removal of fluid to the sample analysis area; and a vent for expulsion of air from the container. The substrate platform may be used for covalent immobilization of polypeptides and nucleic acids and may be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide, such as a scanner.
PCT/IB2002/004726 2001-10-25 2002-10-25 Closed substrate platforms suitable for analysis of biomolecules WO2003036298A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002348982A AU2002348982A1 (en) 2001-10-25 2002-10-25 Closed substrate platforms suitable for analysis of biomolecules

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
PCT/IB2001/002902 WO2002097398A2 (en) 2000-10-25 2001-10-25 Closed substrate platforms suitable for analysis of biomolecules
US10/032,381 2001-10-25
US10/032,381 US20030152927A1 (en) 2000-10-25 2001-10-25 Closed substrate platforms suitable for analysis of biomolecules
IBPCT/IB01/02902 2001-10-25
US10/057,841 2002-01-24
US10/057,841 US20030138969A1 (en) 2002-01-24 2002-01-24 Closed substrate platforms suitable for analysis of biomolecules
DKPA200200133 2002-01-25
DKPA200200133 2002-01-25

Publications (2)

Publication Number Publication Date
WO2003036298A2 WO2003036298A2 (en) 2003-05-01
WO2003036298A3 true WO2003036298A3 (en) 2003-10-16

Family

ID=27439854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/004726 WO2003036298A2 (en) 2001-10-25 2002-10-25 Closed substrate platforms suitable for analysis of biomolecules

Country Status (2)

Country Link
AU (1) AU2002348982A1 (en)
WO (1) WO2003036298A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524672B2 (en) 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
JP5254040B2 (en) 2006-01-18 2013-08-07 アルゴス セラピューティクス，インコーポレイティド System and method for processing samples in a closed container and associated apparatus
KR101051385B1 (en) * 2006-11-30 2011-07-22 아크레이 가부시키가이샤 Primer set for obesity gene amplification, reagent for amplifying obesity gene comprising same and use thereof
JP2011124253A (en) 2009-12-08 2011-06-23 Sony Corp Method of manufacturing semiconductor laser, semiconductor laser, optical disk device, method of manufacturing semiconductor device and semiconductor device
CN101817495B (en) * 2010-03-25 2012-03-14 湖南大学 Micro fluid control chip and preparation method and application thereof
CH703278B1 (en) * 2010-06-15 2016-11-15 Csem Centre Suisse D'electronique Et De Microtechnique Sa - Rech Et Développement Device and platform for multiplex analysis.
US10222391B2 (en) 2011-12-07 2019-03-05 The Johns Hopkins University System and method for screening a library of samples
EP3581275B1 (en) * 2016-06-15 2022-08-10 Hamilton Company Pipette tip coupling device and pipette tip assembly
CN111304058B (en) * 2020-03-26 2023-11-28 河南科技大学 Microfluidic chip for detecting gram-negative bacteria genes and detection method
MX2021013866A (en) * 2021-11-11 2023-05-12 Jesus Raul Beltran Ramirez Biological sample reading device.

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225163A (en) * 1989-08-18 1993-07-06 Angenics, Inc. Reaction apparatus employing gravitational flow
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
WO2001026813A2 (en) * 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
US20010006785A1 (en) * 1997-04-28 2001-07-05 J. Michael Ramsey Method and apparatus for analyzing nucleic acids
WO2001054813A2 (en) * 2000-01-11 2001-08-02 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
EP1201304A2 (en) * 2000-10-25 2002-05-02 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Microstructured platform for examining a liquid
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225163A (en) * 1989-08-18 1993-07-06 Angenics, Inc. Reaction apparatus employing gravitational flow
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
US20010006785A1 (en) * 1997-04-28 2001-07-05 J. Michael Ramsey Method and apparatus for analyzing nucleic acids
WO2001026813A2 (en) * 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
WO2001054813A2 (en) * 2000-01-11 2001-08-02 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
EP1201304A2 (en) * 2000-10-25 2002-05-02 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Microstructured platform for examining a liquid
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays

Also Published As

Publication number Publication date
AU2002348982A1 (en) 2003-05-06
WO2003036298A2 (en) 2003-05-01

Similar Documents

Publication Publication Date Title
WO2002061387A3 (en) Open substrate platforms suitable for analysis of biomolecules
WO2005003723A3 (en) Method for uniform application of fluid into a reactive reagent area
GB0312800D0 (en) Biological apparatus
WO2003036298A3 (en) Closed substrate platforms suitable for analysis of biomolecules
EP1710587A3 (en) Nucleic acid detection method
CA2181190A1 (en) Mesoscale Sample Preparation Device and Systems for Determination and Processing of Analytes
AU2002367839A1 (en) Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
WO2003036265A8 (en) Assay systems with adjustable fluid communication
WO2005019836A8 (en) Apparatus for processing a fluid sample
CA2461734A1 (en) Container uncapping apparatus and method
EP2423667A3 (en) Unitary Cartridge for Particle Processing
WO2002044703A3 (en) High throughput capillary electrophoresis system
WO2002095396A3 (en) In line test device and methods of use
EP2299256A3 (en) Microfabricated crossflow devices and methods
EP1188482A3 (en) Apparatus & method for conducting assays
WO2001055691A3 (en) Waveguide plate and sensor platforms based thereon, arrangements of sample containers and detection methods
EP2305809A3 (en) Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
WO2003060157A3 (en) Fluid manipulation in a microfabricated reaction chamber system
WO2004064972A3 (en) Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
WO2000038838A8 (en) Apparatus and methods for efficient processing of biological samples on slides
AU2002367965A1 (en) High throughput methods and devices for assaying analytes in a fluid sample
CA2262739A1 (en) Low background multi-well plates for fluorescence measurements of biological and biochemical samples
CA2500407A1 (en) Diagnostic devices
DE69723349D1 (en) Device for taking harmful liquid samples, especially those loaded with solid particles
WO2004073862A3 (en) Biological specimen handling apparatus and method

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP