WO2003036258A3 - System and method for determining radius of gyration, molecular weight, and intrinsic viscosity of a polymeric distribution using gel permeation chromatography and light-scattering detection - Google Patents

System and method for determining radius of gyration, molecular weight, and intrinsic viscosity of a polymeric distribution using gel permeation chromatography and light-scattering detection Download PDF

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Publication number
WO2003036258A3
WO2003036258A3 PCT/US2002/033945 US0233945W WO03036258A3 WO 2003036258 A3 WO2003036258 A3 WO 2003036258A3 US 0233945 W US0233945 W US 0233945W WO 03036258 A3 WO03036258 A3 WO 03036258A3
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WO
WIPO (PCT)
Prior art keywords
gyration
gel permeation
permeation chromatography
molecular weight
light
Prior art date
Application number
PCT/US2002/033945
Other languages
French (fr)
Other versions
WO2003036258A2 (en
Inventor
Rong Xie
Yefim Brun
Marc V Gorenstein
Original Assignee
Waters Investments Ltd
Rong Xie
Yefim Brun
Marc V Gorenstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Investments Ltd, Rong Xie, Yefim Brun, Marc V Gorenstein filed Critical Waters Investments Ltd
Priority to JP2003538708A priority Critical patent/JP2005507077A/en
Priority to AU2002348395A priority patent/AU2002348395A1/en
Priority to EP02782217A priority patent/EP1438575A4/en
Publication of WO2003036258A2 publication Critical patent/WO2003036258A2/en
Publication of WO2003036258A3 publication Critical patent/WO2003036258A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8693—Models, e.g. prediction of retention times, method development and validation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N2011/0026—Investigating specific flow properties of non-Newtonian fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • G01N2030/885—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds involving polymers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/78—Detectors specially adapted therefor using more than one detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8651—Recording, data aquisition, archiving and storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/44—Resins; Plastics; Rubber; Leather
    • G01N33/442—Resins; Plastics

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A system and method for analyzing data from a gel permeation chromatography (GPC) or size exclusion chromatography (SEC) system for determining a polymeric sample's radius of gyration. Data from two or more detectors (18) is used with a least-squares minimization fit (20). A novel method includes the simultaneous determination of a sample's radius of gyration using data from a light scattering detector that collects data from at least two incident angles. Detectors within the inventive method include a multi-angle light scattering (LS) detector, viscometer (V) and a refractive index (RI) detector.
PCT/US2002/033945 2001-10-23 2002-10-23 System and method for determining radius of gyration, molecular weight, and intrinsic viscosity of a polymeric distribution using gel permeation chromatography and light-scattering detection WO2003036258A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2003538708A JP2005507077A (en) 2001-10-23 2002-10-23 System and method for determining the turning radius, molecular weight and intrinsic viscosity of polymer distributions using gel permeation chromatography and light scattering detection
AU2002348395A AU2002348395A1 (en) 2001-10-23 2002-10-23 System and method for determining radius of gyration, molecular weight, and intrinsic viscosity of a polymeric distribution using gel permeation chromatography and light-scattering detection
EP02782217A EP1438575A4 (en) 2001-10-23 2002-10-23 System and method for determining radius of gyration, molecular weight, and intrinsic viscosity of a polymeric distribution using gel permeation chromatography and light-scattering detection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33525401P 2001-10-23 2001-10-23
US60/335,254 2001-10-23

Publications (2)

Publication Number Publication Date
WO2003036258A2 WO2003036258A2 (en) 2003-05-01
WO2003036258A3 true WO2003036258A3 (en) 2003-06-05

Family

ID=23310959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033945 WO2003036258A2 (en) 2001-10-23 2002-10-23 System and method for determining radius of gyration, molecular weight, and intrinsic viscosity of a polymeric distribution using gel permeation chromatography and light-scattering detection

Country Status (4)

Country Link
EP (1) EP1438575A4 (en)
JP (1) JP2005507077A (en)
AU (1) AU2002348395A1 (en)
WO (1) WO2003036258A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7579403B2 (en) 2006-04-04 2009-08-25 E. I. Du Pont De Nemours And Company Stain resist comprising hyperbranched maleic anhydride-diene polymers
US7579420B2 (en) 2006-04-04 2009-08-25 E. I. Du Pont De Nemours And Company Hyperbranched maleic anhydride-diene polymers
KR101412629B1 (en) 2013-01-14 2014-06-26 한국수력원자력 주식회사 Device for measuring viscosity
CN104280494B (en) * 2013-07-17 2017-03-15 湖北航天化学技术研究所 Methyl vinyl phenyl raw-silastic continuously MPVQ molecular weight determinations
US11938145B2 (en) 2018-07-27 2024-03-26 ARC Medical Inc. Low endotoxin fucan compositions, systems, and methods
MX2021000865A (en) * 2019-03-05 2021-06-15 Arc Medical Devices Inc Method for predicting a molecular weight distribution of a biopolymer blend.
WO2020261321A1 (en) * 2019-06-24 2020-12-30 日本電信電話株式会社 Analysis method
CN113866047B (en) * 2021-10-21 2024-04-02 南京信息工程大学 Viscosity coefficient optical measurement device and method based on machine learning

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6064945A (en) * 1998-02-20 2000-05-16 Waters Investments Limited System and method for determining molecular weight and intrinsic viscosity of a polymeric distribution using gel permeation chromatography

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265226B1 (en) * 1998-04-03 2001-07-24 Symyx Technologies, Inc. Automated sampling methods for rapid characterization of polymers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6064945A (en) * 1998-02-20 2000-05-16 Waters Investments Limited System and method for determining molecular weight and intrinsic viscosity of a polymeric distribution using gel permeation chromatography

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PROSA ET AL.: "A SAXS study of the internal structure of dendritic polymer systems", JOURNAL OF POLYMER SCIENCE: PART B: POLYMER PHYSICS, vol. 35, 15 May 1997 (1997-05-15), pages 2913 - 2924, XP002961658 *
See also references of EP1438575A4 *
TOBITA HIDETAKA: "Dimensions of branched polymers formed in simultaneous long-chain branching and random scission", JOURNAL OF POLYMER SCIENCE: PART B: POLYMER PHYSICS, vol. 39, 18 June 2001 (2001-06-18), pages 2960 - 2968, XP002961659 *

Also Published As

Publication number Publication date
JP2005507077A (en) 2005-03-10
AU2002348395A1 (en) 2003-05-06
EP1438575A4 (en) 2009-05-13
WO2003036258A2 (en) 2003-05-01
EP1438575A2 (en) 2004-07-21

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