WO2003035692A3 - Modified peptides and their uses - Google Patents

Modified peptides and their uses Download PDF

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Publication number
WO2003035692A3
WO2003035692A3 PCT/GB2002/004785 GB0204785W WO03035692A3 WO 2003035692 A3 WO2003035692 A3 WO 2003035692A3 GB 0204785 W GB0204785 W GB 0204785W WO 03035692 A3 WO03035692 A3 WO 03035692A3
Authority
WO
WIPO (PCT)
Prior art keywords
terminal domain
chain
pro
procollagen
modified peptides
Prior art date
Application number
PCT/GB2002/004785
Other languages
French (fr)
Other versions
WO2003035692A2 (en
Inventor
Karl Ernest Kadler
Neil John Bulleid
Original Assignee
Univ Manchester
Karl Ernest Kadler
Neil John Bulleid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0125369A external-priority patent/GB0125369D0/en
Priority claimed from GB0125372A external-priority patent/GB0125372D0/en
Application filed by Univ Manchester, Karl Ernest Kadler, Neil John Bulleid filed Critical Univ Manchester
Publication of WO2003035692A2 publication Critical patent/WO2003035692A2/en
Publication of WO2003035692A3 publication Critical patent/WO2003035692A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A modified pro-α chain comprising a triple helix forming domain linked to at least an N-terminal domain, the N-terminal domain containing a polypeptide from at least part of a proteoglycan core, such as decorin. The pro-α chain may form part of a procollagen molecule that has the N-terminal domain retained. The procollagen molecules may be incorporated into collagen polymers, matrices and gels and be used for such applications as wound healing, tissue replacement and cosmetic treatments.
PCT/GB2002/004785 2001-10-23 2002-10-23 Modified peptides and their uses WO2003035692A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0125369.9 2001-10-23
GB0125369A GB0125369D0 (en) 2001-10-23 2001-10-23 Wound healing
GB0125372A GB0125372D0 (en) 2001-10-23 2001-10-23 Modified peptides
GB0125372.3 2001-10-23

Publications (2)

Publication Number Publication Date
WO2003035692A2 WO2003035692A2 (en) 2003-05-01
WO2003035692A3 true WO2003035692A3 (en) 2003-10-30

Family

ID=26246686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/004785 WO2003035692A2 (en) 2001-10-23 2002-10-23 Modified peptides and their uses

Country Status (1)

Country Link
WO (1) WO2003035692A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0309064D0 (en) 2003-04-22 2003-05-28 Univ Manchester Modified peptides and their uses

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0704532A2 (en) * 1994-06-10 1996-04-03 United States Surgical Corporation Recombinant chimeric proteins and methods of use thereof
US5986052A (en) * 1993-01-06 1999-11-16 The General Hospital Corporation Fusion polypeptide containing fragments of cartilage matrix protein and link protein
EP0985732A2 (en) * 1998-09-07 2000-03-15 Terumo Kabushiki Kaisha Trimeric chimera protein and collagen matrix containing chimera protein
EP0992586A2 (en) * 1998-10-09 2000-04-12 United States Surgical Corporation Extracellular matrix proteins with modified amino acid
WO2001034647A2 (en) * 1999-11-12 2001-05-17 Fibrogen, Inc. Animal collagens and gelatins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986052A (en) * 1993-01-06 1999-11-16 The General Hospital Corporation Fusion polypeptide containing fragments of cartilage matrix protein and link protein
EP0704532A2 (en) * 1994-06-10 1996-04-03 United States Surgical Corporation Recombinant chimeric proteins and methods of use thereof
EP0985732A2 (en) * 1998-09-07 2000-03-15 Terumo Kabushiki Kaisha Trimeric chimera protein and collagen matrix containing chimera protein
EP0992586A2 (en) * 1998-10-09 2000-04-12 United States Surgical Corporation Extracellular matrix proteins with modified amino acid
WO2001034647A2 (en) * 1999-11-12 2001-05-17 Fibrogen, Inc. Animal collagens and gelatins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GRAHAM HK ET AL.: "Identification of Collagen Fibril Fusion during Vertebrate Tendon Morphogenesis. The Process Relies on Unipolar Fibrills and is Regulated by Collagen-proteoglycan Interaction", JOURNAL OF MOLECULAR BIOLOGY, vol. 295, no. 4, 28 January 2000 (2000-01-28), pages 891 - 902, XP001161220 *

Also Published As

Publication number Publication date
WO2003035692A2 (en) 2003-05-01

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