WO2003035163A3 - Methods and apparatus for effectuating a lasting change in a neural-function of a patient - Google Patents

Methods and apparatus for effectuating a lasting change in a neural-function of a patient Download PDF

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Publication number
WO2003035163A3
WO2003035163A3 PCT/US2002/031127 US0231127W WO03035163A3 WO 2003035163 A3 WO2003035163 A3 WO 2003035163A3 US 0231127 W US0231127 W US 0231127W WO 03035163 A3 WO03035163 A3 WO 03035163A3
Authority
WO
WIPO (PCT)
Prior art keywords
neural
brain
neuroplasticity
stimulation site
expected
Prior art date
Application number
PCT/US2002/031127
Other languages
French (fr)
Other versions
WO2003035163A2 (en
Inventor
Bradford Evan Gliner
Brad Fowler
Andrew D Firlik
Jeffrey Balzer
Alan J Levy
Original Assignee
Vertis Neuroscience Inc
Bradford Evan Gliner
Brad Fowler
Andrew D Firlik
Jeffrey Balzer
Alan J Levy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertis Neuroscience Inc, Bradford Evan Gliner, Brad Fowler, Andrew D Firlik, Jeffrey Balzer, Alan J Levy filed Critical Vertis Neuroscience Inc
Priority to AU2002330165A priority Critical patent/AU2002330165A1/en
Publication of WO2003035163A2 publication Critical patent/WO2003035163A2/en
Publication of WO2003035163A3 publication Critical patent/WO2003035163A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0531—Brain cortex electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0534—Electrodes for deep brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0539—Anchoring of brain electrode systems, e.g. within burr hole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3756—Casings with electrodes thereon, e.g. leadless stimulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Rehabilitation Therapy (AREA)
  • Electrotherapy Devices (AREA)

Abstract

The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
PCT/US2002/031127 2001-09-28 2002-09-27 Methods and apparatus for effectuating a lasting change in a neural-function of a patient WO2003035163A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002330165A AU2002330165A1 (en) 2001-09-28 2002-09-27 Methods and apparatus for effectuating a lasting change in a neural-function of a patient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32597801P 2001-09-28 2001-09-28
US60/325,978 2001-09-28

Publications (2)

Publication Number Publication Date
WO2003035163A2 WO2003035163A2 (en) 2003-05-01
WO2003035163A3 true WO2003035163A3 (en) 2003-09-18

Family

ID=23270271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/031127 WO2003035163A2 (en) 2001-09-28 2002-09-27 Methods and apparatus for effectuating a lasting change in a neural-function of a patient

Country Status (2)

Country Link
AU (1) AU2002330165A1 (en)
WO (1) WO2003035163A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533155B2 (en) 2014-08-15 2017-01-03 Axonics Modulation Technologies, Inc. Methods for determining neurostimulation electrode configurations based on neural localization
US9555246B2 (en) 2014-08-15 2017-01-31 Axonics Modulation Technologies, Inc. Electromyographic lead positioning and stimulation titration in a nerve stimulation system for treatment of overactive bladder
US11848090B2 (en) 2019-05-24 2023-12-19 Axonics, Inc. Trainer for a neurostimulator programmer and associated methods of use with a neurostimulation system

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153256B2 (en) 2003-03-07 2006-12-26 Neuronetics, Inc. Reducing discomfort caused by electrical stimulation
US8118722B2 (en) 2003-03-07 2012-02-21 Neuronetics, Inc. Reducing discomfort caused by electrical stimulation
US7107104B2 (en) 2003-05-30 2006-09-12 Medtronic, Inc. Implantable cortical neural lead and method
US7104947B2 (en) 2003-11-17 2006-09-12 Neuronetics, Inc. Determining stimulation levels for transcranial magnetic stimulation
US7651459B2 (en) 2004-01-06 2010-01-26 Neuronetics, Inc. Method and apparatus for coil positioning for TMS studies
US8177702B2 (en) 2004-04-15 2012-05-15 Neuronetics, Inc. Method and apparatus for determining the proximity of a TMS coil to a subject's head
US7601115B2 (en) 2004-05-24 2009-10-13 Neuronetics, Inc. Seizure therapy method and apparatus
US7857746B2 (en) 2004-10-29 2010-12-28 Nueronetics, Inc. System and method to reduce discomfort using nerve stimulation
US8088058B2 (en) 2005-01-20 2012-01-03 Neuronetics, Inc. Articulating arm
US7396326B2 (en) 2005-05-17 2008-07-08 Neuronetics, Inc. Ferrofluidic cooling and acoustical noise reduction in magnetic stimulators
US7824324B2 (en) 2005-07-27 2010-11-02 Neuronetics, Inc. Magnetic core for medical procedures
US8128549B2 (en) 2007-02-20 2012-03-06 Neuronetics, Inc. Capacitor failure detection
US9884200B2 (en) 2008-03-10 2018-02-06 Neuronetics, Inc. Apparatus for coil positioning for TMS studies
WO2009131726A1 (en) * 2008-04-21 2009-10-29 Medtronic, Inc. Spiral lead
US10092762B2 (en) 2014-08-15 2018-10-09 Axonics Modulation Technologies, Inc. Integrated electromyographic clinician programmer for use with an implantable neurostimulator
US11439829B2 (en) 2019-05-24 2022-09-13 Axonics, Inc. Clinician programmer methods and systems for maintaining target operating temperatures

Citations (5)

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US5224491A (en) * 1991-01-07 1993-07-06 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5255678A (en) * 1991-06-21 1993-10-26 Ecole Polytechnique Mapping electrode balloon
WO1994007564A2 (en) * 1992-10-01 1994-04-14 Cardiac Pacemakers, Inc. Stent-type defibrillation electrode structures
US5423864A (en) * 1992-12-11 1995-06-13 Siemens Elema Ab Difibrillation system
US5722401A (en) * 1994-10-19 1998-03-03 Cardiac Pathways Corporation Endocardial mapping and/or ablation catheter probe

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US4140133A (en) 1977-04-26 1979-02-20 Moskovsky Oblastnoi Nauchno-Issledovatelsky Institut Akusherstva I Ginekolog Ii Device for pulse current action on central nervous system
US4844075A (en) 1984-01-09 1989-07-04 Pain Suppression Labs, Inc. Transcranial stimulation for the treatment of cerebral palsy
US4646744A (en) 1984-06-29 1987-03-03 Zion Foundation Method and treatment with transcranially applied electrical signals
US5092835A (en) 1990-07-06 1992-03-03 Schurig Janet L S Brain and nerve healing power apparatus and method
US5540736A (en) 1993-08-02 1996-07-30 Haimovich; Yechiel Transcranial electrostimulation apparatus having two electrode pairs and independent current generators
US5885976A (en) 1995-05-08 1999-03-23 Sandyk; Reuven Methods useful for the treatment of neurological and mental disorders related to deficient serotonin neurotransmission and impaired pineal melatonin functions
ES2290967T3 (en) 1996-08-15 2008-02-16 Neotonus, Inc. APPARATUS FOR TRANSCRANEAL BRAIN STIMULATION.
US5938688A (en) 1997-10-22 1999-08-17 Cornell Research Foundation, Inc. Deep brain stimulation method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5224491A (en) * 1991-01-07 1993-07-06 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5255678A (en) * 1991-06-21 1993-10-26 Ecole Polytechnique Mapping electrode balloon
WO1994007564A2 (en) * 1992-10-01 1994-04-14 Cardiac Pacemakers, Inc. Stent-type defibrillation electrode structures
US5423864A (en) * 1992-12-11 1995-06-13 Siemens Elema Ab Difibrillation system
US5722401A (en) * 1994-10-19 1998-03-03 Cardiac Pathways Corporation Endocardial mapping and/or ablation catheter probe

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533155B2 (en) 2014-08-15 2017-01-03 Axonics Modulation Technologies, Inc. Methods for determining neurostimulation electrode configurations based on neural localization
US9555246B2 (en) 2014-08-15 2017-01-31 Axonics Modulation Technologies, Inc. Electromyographic lead positioning and stimulation titration in a nerve stimulation system for treatment of overactive bladder
US9561372B2 (en) 2014-08-15 2017-02-07 Axonics Modulation Technologies, Inc. Electromyographic lead positioning and stimulation titration in a nerve stimulation system for treatment of overactive bladder
US11848090B2 (en) 2019-05-24 2023-12-19 Axonics, Inc. Trainer for a neurostimulator programmer and associated methods of use with a neurostimulation system

Also Published As

Publication number Publication date
WO2003035163A2 (en) 2003-05-01
AU2002330165A1 (en) 2003-05-06

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