WO2003033703A3 - Human gtp-activator protein for rab-like gtpase - Google Patents

Human gtp-activator protein for rab-like gtpase Download PDF

Info

Publication number
WO2003033703A3
WO2003033703A3 PCT/US2002/032597 US0232597W WO03033703A3 WO 2003033703 A3 WO2003033703 A3 WO 2003033703A3 US 0232597 W US0232597 W US 0232597W WO 03033703 A3 WO03033703 A3 WO 03033703A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
gap
human
antibodies
proteins
Prior art date
Application number
PCT/US2002/032597
Other languages
French (fr)
Other versions
WO2003033703A2 (en
Inventor
Jian Zhang
Original Assignee
Amersham Biosciences Sv Corp
Jian Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Sv Corp, Jian Zhang filed Critical Amersham Biosciences Sv Corp
Publication of WO2003033703A2 publication Critical patent/WO2003033703A2/en
Publication of WO2003033703A3 publication Critical patent/WO2003033703A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity

Abstract

The invention provides isolated nucleic acids that encode a human GTP-activator protein for RAE-like GTPase (GAP N) , and fragments thereof, vectors for propagating and expressing GAP N nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel GAP N isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human GAP N nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human GAP N gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the GAP N nucleic acids, proteins, and antibodies of the present invention.
PCT/US2002/032597 2001-10-15 2002-10-11 Human gtp-activator protein for rab-like gtpase WO2003033703A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33032301P 2001-10-15 2001-10-15
US60/330,323 2001-10-15

Publications (2)

Publication Number Publication Date
WO2003033703A2 WO2003033703A2 (en) 2003-04-24
WO2003033703A3 true WO2003033703A3 (en) 2003-10-30

Family

ID=23289252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032597 WO2003033703A2 (en) 2001-10-15 2002-10-11 Human gtp-activator protein for rab-like gtpase

Country Status (1)

Country Link
WO (1) WO2003033703A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000055350A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human cancer associated gene sequences and polypeptides
WO2000077197A1 (en) * 1999-06-11 2000-12-21 Human Genome Sciences, Inc. 47 human secreted proteins
WO2001029221A2 (en) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Proteins and polynucleotides encoding them
WO2001042451A2 (en) * 1999-12-08 2001-06-14 Genset FULL-LENGTH HUMAN cDNAs ENCODING POTENTIALLY SECRETED PROTEINS
WO2002059260A2 (en) * 2000-11-17 2002-08-01 Hyseq, Inc. Nucleic acids and polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000055350A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human cancer associated gene sequences and polypeptides
WO2000077197A1 (en) * 1999-06-11 2000-12-21 Human Genome Sciences, Inc. 47 human secreted proteins
WO2001029221A2 (en) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Proteins and polynucleotides encoding them
WO2001042451A2 (en) * 1999-12-08 2001-06-14 Genset FULL-LENGTH HUMAN cDNAs ENCODING POTENTIALLY SECRETED PROTEINS
WO2002059260A2 (en) * 2000-11-17 2002-08-01 Hyseq, Inc. Nucleic acids and polypeptides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 1 March 2001 (2001-03-01), KAWABATA A ET AL: "Hypothetical protein FLJ22474.", XP002246896, Database accession no. Q9H695 *
DATABASE EMBL [online] 29 September 2000 (2000-09-29), SUGANO S ET AL: "Homo sapiens cDNA: FLJ22474 fis, clone HRC10568.", XP002246895, Database accession no. AK026127 *
DATABASE EMBL [online] 8 February 2001 (2001-02-08), ADACHI J ET AL: "Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810059F03 product:GH REGULATED TBC PROTEIN-1, full insert sequence.", XP002246894, Database accession no. AK007905; Q9D8L8 *
DEHLINGER P J ET AL: "An Inventor's Guide to Patenting Polynucleotide Inventions", BIOTECHNOLOGY LAW REPORT, LIEBERT, NEW YORK, NY, US, vol. 19, no. 2, 2000, pages 155 - 163, XP000995652, ISSN: 0730-031X *
LU CHUNXIA ET AL: "Grtp1, a novel gene regulated by growth hormone.", ENDOCRINOLOGY, vol. 142, no. 10, October 2001 (2001-10-01), pages 4568 - 4571, XP002246893, ISSN: 0013-7227 *

Also Published As

Publication number Publication date
WO2003033703A2 (en) 2003-04-24

Similar Documents

Publication Publication Date Title
WO2003042362A3 (en) PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
WO2001087978A3 (en) Human abc transporter and its use
MXPA04004561A (en) A human matrix metalloproteinase and uses therefor.
EP1239051A3 (en) Human posh-like protein 1
AU2002320301A1 (en) Novel pgc-1 isoforms and uses therefor
EP1281758A3 (en) Four human zinc-finger-containing proteins : MDZ3, MDZ4, MDZ7 and MDZ12
WO2002055701A3 (en) Human sugar transporter proteins, potassium channel proteins, phospholipid transporter proteins and methods of use thereof
WO2003033660A3 (en) 9136, a human aldehyde dehydrogenase family member and uses therefor
WO2001092493A3 (en) 21956 and 25856, human aminopeptidases and uses thereof
WO2003054144A8 (en) Human ras interacting protein
WO2003037931A3 (en) Human angiomotin-like protein 1
WO2002024750A3 (en) Human kidney tumor overexpressed membrane protein 1
AU2001280639A1 (en) 13237,18480,2245 or 16228 human protein kinase molecules and uses therefor
WO2003033703A3 (en) Human gtp-activator protein for rab-like gtpase
WO2003031621A3 (en) A human g protein coupled receptor
WO2002026818A3 (en) Human nedd-1
EP1229132A3 (en) Human ralgds-like protein 3
EP1273660A3 (en) Human sodium-hydrogen exchanger like protein 1
EP1262488A3 (en) Human LCCL-domain containing protein
WO2001075121A3 (en) 16836, a human phospholipase c family member and uses thereof
EP1231216A3 (en) Human gtp-rho binding protein 2
EP1243660A3 (en) Human udp-Galnac:polypeptide n-acetylgalatosaminyltransferase 10
EP1229046A3 (en) Human testis expressed patched like protein
EP1227156A3 (en) A human protein kinase domain-containing protein
EP1430070A4 (en) Novel clark protein and nucleic acid molecules and uses therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP