WO2003031461A3 - N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response - Google Patents

N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response Download PDF

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Publication number
WO2003031461A3
WO2003031461A3 PCT/US2002/031800 US0231800W WO03031461A3 WO 2003031461 A3 WO2003031461 A3 WO 2003031461A3 US 0231800 W US0231800 W US 0231800W WO 03031461 A3 WO03031461 A3 WO 03031461A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune response
peptide receptor
formyl peptide
platelet
activation
Prior art date
Application number
PCT/US2002/031800
Other languages
French (fr)
Other versions
WO2003031461A2 (en
Inventor
Julie A Lekstrom-Himes
Allan D Kirk
Meggan Czapiga
David E Kleiner
Original Assignee
Us Navy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Navy filed Critical Us Navy
Priority to AU2002332042A priority Critical patent/AU2002332042A1/en
Publication of WO2003031461A2 publication Critical patent/WO2003031461A2/en
Publication of WO2003031461A3 publication Critical patent/WO2003031461A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to N-formyl peptides that induce an immune response, specifically, stimulating mobilization of platelets to a site of injury, thereby healing wounds. Further, the invention relates to N-formyl peptide receptor inhibitors, specifically N-formyl peptide receptor antibodies, that inhibit an immune response, thereby blocking inflammation and the mobilization of platelets and other phagocytic cells to a site of injury.
PCT/US2002/031800 2001-10-05 2002-10-04 N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response WO2003031461A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002332042A AU2002332042A1 (en) 2001-10-05 2002-10-04 N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32747701P 2001-10-05 2001-10-05
US60/327,477 2001-10-05

Publications (2)

Publication Number Publication Date
WO2003031461A2 WO2003031461A2 (en) 2003-04-17
WO2003031461A3 true WO2003031461A3 (en) 2003-07-03

Family

ID=23276701

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/031800 WO2003031461A2 (en) 2001-10-05 2002-10-04 N-formyl peptide receptor mediation of platelet chemotaxis toward injured cells and activation of immune response

Country Status (2)

Country Link
AU (1) AU2002332042A1 (en)
WO (1) WO2003031461A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7074891B2 (en) * 2003-02-07 2006-07-11 Posco Leukocyte stimulating peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398143A1 (en) * 1989-05-09 1990-11-22 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
WO1993011784A1 (en) * 1991-12-13 1993-06-24 Duke University Methods for inhibition or stimulation of the inflammatory response
WO2000066622A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T20/dp178 and t21/dp107 are activators of human phagocyte formyl peptide receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398143A1 (en) * 1989-05-09 1990-11-22 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
WO1993011784A1 (en) * 1991-12-13 1993-06-24 Duke University Methods for inhibition or stimulation of the inflammatory response
WO2000066622A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T20/dp178 and t21/dp107 are activators of human phagocyte formyl peptide receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LOITTO V.M. ET AL.: "Assessment of neutrophil N-formyl peptide receptors by using antibodies and fluorescent peptides", J. LEUKOC. BIOL., vol. 69, no. 5, May 2001 (2001-05-01), pages 762 - 771, XP002962245 *
MULLER-LADNER U. ET AL.: "Enhanced expression of chemotactic receptors in multiple sclerosis lesions", J. NEUROL. SCI., vol. 144, no. 1-2, December 1996 (1996-12-01), pages 135 - 141, XP002962248 *
NIEDEL J. ET AL.: "Receptor-mediated up-take and degradation of 1241-chemotactic peptide by human neutropils", J. BIOL. CHEM., vol. 254, no. 21, 10 November 1979 (1979-11-10), pages 10700 - 10706, XP002962246 *
SCHREIBER R.E. ET AL.: "Reconstitution of recombinant N-formyl chemotactic peptide receptor with G protein", J. LEUKOC. BIOL., vol. 53, no. 4, April 1993 (1993-04-01), pages 470 - 474, XP002962247 *

Also Published As

Publication number Publication date
AU2002332042A1 (en) 2003-04-22
WO2003031461A2 (en) 2003-04-17

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