WO2003030970A1

WO2003030970A1 - Medicinal liquid injector having filling auxiliary function

Info

Publication number: WO2003030970A1
Application number: PCT/JP2002/009597
Authority: WO
Inventors: Keiichi Yamada; Takeharu Kobayashi
Original assignee: Daiken Iki Kabushiki Kaisha
Priority date: 2001-10-02
Filing date: 2002-09-19
Publication date: 2003-04-17
Also published as: JP2003111839A

Abstract

A medicinal liquid injector for injecting a medicinal liquid filled in a tubular expansion container into a patient, comprising an injection port (3) for injecting a medicinal liquid into a tubular expansion container (2) in order to lighten the operator’s burden of medicinal liquid filling operation, a delivery line (4) disposed at one end of the expansion container (2) for delivering a discharged medicinal liquid toward a patient, a flow rate adjuster (5) installed in this delivery line (4), a protective case (6) for protecting the expansion container (2), a medicinal liquid filling auxiliary means (7) for assisting the medicinal liquid filling operation, and a shape retaining member (9) having the initial expansion form of the expansion container (2).

Description

Description Chemical liquid injector with filling assist function Technical field

The present invention relates to a drug solution injection device used in the medical field, and more particularly to a drug solution injection device that reduces the burden on a user and improves the injection accuracy. Background art

Conventionally, as a drug solution injection device used to inject a drug solution into a patient at a medical site, a device such as Japanese Patent Publication No. 4-36072 is known. This is a long, generally cylindrical elastomeric hollow bag 202 having an open end as shown in FIG. 8 and a long, roughly cylindrical cylinder extending into the bag 202. Stress member 204 having an expanded diameter greater than the inner diameter of the bag 202 to radially prestress the bag 202. give. Further, means for attaching the both ends of the bag 202 to the stress member 204 to apply a prestress to the bag in the axial direction are provided, and the liquid is not filled. In this state, the bag 202 is fixed to the stress member 204 with some stress applied in both the radial direction and the axial direction. In addition, in this device, the first lumen 2 13 communicating with the inflow duct 214 at the periphery of the stress member 204 and the backflow of fluid from the bag 202 into the inflow duct 2 14 And a second lumen 225 substantially parallel to the first lumen 213. The second lumen 225 communicates with the outflow duct 224 located near the periphery of the stress member 204 and the middle thereof. In addition, a capillary 228 is provided in the second lumen 225 as a flow adjusting means, and the second lumen 225 is connected to the outlet port 212 via the capillary 228.

Further, this device is provided with a plurality of indicator bumps 2 16 for indicating that the bag 202 placed on the stress member 204 as shown in FIG. 9 which is a partial cross-sectional side view is almost empty. Is provided. In the case of using the liquid injector with the above configuration, if an appropriate liquid is injected into the device through the filling port 2 11 using a syringe, etc., the first lumen 2 13 and the one-way valve means 2 2 1 As a result, the chemical liquid enters the bag 202, and due to the effect of the valve means 221, no reverse flow of the chemical liquid toward the filling port occurs, and the chemical liquid is stored in the bag 202. Then, the chemical solution pressurized by the shrinking force of the bag 202 enters the capillary tube 228 via the outflow duct 222, and as a result, the chemical solution whose flow is restricted has a predetermined flow rate, and Lumen 2 25 and injected into the patient via outlet port 2 1 2 In addition, indicator bump 2 16 is invisible when bag 202 is inflated, but as bag 202 approaches emptying Since the stress members 204 become visible in order from both ends, it is possible to determine the discharge amount of the chemical solution and the filling amount.

In this apparatus, the bag 202 is in a stressed state (pre-stressed state) in both the diameter direction and the axial direction before filling with the chemical solution, so that the bag 200 at the time of maximum filling of the chemical solution and immediately before the discharge is completed. The pressure inside is kept almost unchanged. Fig. 6 shows the relationship between the pressure of the drug solution and the time when the drug solution is injected by the drug solution injector using an extensible container. The pressure line (dotted line) of this device is higher than the pressure line (dotted line) of the liquid injector that does not have a prestressed structure, and the pressure drop over time is reduced. You can see that there is.

However, the conventional liquid injector injects a liquid drug into a patient through a thin tube such as a catheter, so that a large pressure is generated. Therefore, when filling the device with the chemical solution, the chemical solution is filled against this pressure. For example, using a syringe barrel requires a healthcare professional to press hard on the pusher. Each time it is used, the volume must be filled.For example, if a volume of 300 ml is filled with a 20 ml syringe, 15 operations will be required, and each of the 15 operations will require expansion and contraction. The burden on the operator is considerably large because the operation is performed with the contraction force of the sex container.

In addition, a conventional drug solution injection device using a stretchable container is characterized in that when the stretchable container expands and contracts, its cross-sectional shape changes rapidly from an expanded shape (bale type) to a contracted shape (linear type), resulting in 弹 -shrinkage. As the force increases, the resulting rapid pressure increase (pressure increase A in Figure 6) cannot be avoided. As such, it is very dangerous clinically.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a drug solution injector using a stretchable container that reduces the burden of a filling operation performed by a user and improves the drug solution injection accuracy. . Disclosure of the invention

The present invention relates to a drug solution injector for injecting a drug solution filled in a tube-shaped elastic container into a patient, comprising: an injection port for injecting the drug solution into the elastic container; A delivery pipe for delivering the drug solution discharged from one end toward the patient, a flow rate adjusting device is provided in the delivery pipe, and a body case for protecting the elastic container; and a drug solution. A chemical liquid injection device characterized by providing a chemical liquid filling auxiliary means for assisting the filling operation of the liquid chemical.

According to this medicinal solution injector, when a predetermined medicinal solution is filled into the elastic container via the injection port, the medicinal solution is injected into the patient via the delivery line by the contraction force of the elastic container. Furthermore, since this chemical liquid injection device is provided with a chemical liquid filling auxiliary means, when using this device, the burden of the filling work which must be performed by the medical staff can be reduced.

In this chemical liquid injection device, the filling auxiliary means assists the liquid chemical filling operation, for example, by a relative pressure difference between the elastic container and the elastic container caused by negative pressure inside the main body case.

In this way, by setting the inside of the main body case to a negative pressure (because the negative pressure is set in advance) before the use of the liquid injector, the pressure inside the main body case and outside the elastic container ( Since the pressure difference between the negative pressure) and the pressure inside the elastic container (atmospheric pressure) is generated, the elastic container has the power to expand itself while it is empty. Therefore, when using this medicinal solution injection device, the pushing force (the force of expanding the elastic container by injecting the medicinal solution) when the medical staff fills the medicinal solution using the injection tube is reduced.

The relative pressure difference between the main body case and the elastic container in the filling auxiliary means is set to a differential pressure sufficient to generate a self-expanding force of the elastic container. It should just be.

In this way, when filling the liquid medicine before use of the liquid medicine injection device, the injection tube filled with the liquid medicine is connected to the injection port, and the pressure (negative pressure) inside the main body case and outside the elastic container and By setting the differential pressure of the pressure (atmospheric pressure) in the elastic container to a differential pressure sufficient to generate the self-expanding force of the elastic container, the liquid medicine in the syringe is automatically filled into the device. .

Further, in the drug solution injector of the present invention, it is preferable that a shape maintaining member having a shape at the time of initial expansion in the elastic container is provided in the elastic container.

In this way, a sudden change in the cross-sectional shape of the elastic container from an expanded shape (bale type) to a contracted state (linear type) can be avoided when the elastic container is expanded and contracted. Abrupt pressure changes caused by force changes can also be avoided. As a result, the amount of the drug solution injected into the patient is stabilized. Conversely, this means that the pressure required at the beginning of filling when filling the chemical solution is low, and here also the pressing force for filling the chemical solution is reduced.

Further, in the drug solution injection device of the present invention, an indicator is provided at a free end of the elastic container so that the inside of the main body case can move in the axial direction, and the behavior of the indicator is confirmed from outside the main body case. It is preferable to be able to calculate the remaining amount of the chemical solution or the filling amount in the elastic container from the position relative to the main body case.

According to this configuration, by providing an indicator that can move the inside of the main body case in the axial direction at the free end of the elastic container, the remaining amount of the chemical solution in the elastic container or the filling of the elastic container from the position relative to the main body case is obtained. The amount can be calculated. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a perspective view of a chemical liquid injector according to the present invention.

FIG. 2 is a cross-sectional view taken along the line AA of the drug solution injection device according to the present invention before filling with the drug solution. FIG. 3 is a cross-sectional view taken along the line AA of the chemical liquid injector according to the present invention after filling with the chemical liquid. 4A and 4B are diagrams showing a filling auxiliary means of the drug solution injection device according to the present invention, wherein (a) is a partial cross-sectional view showing a steady state of the filling auxiliary means, (b) is a fiber diagram of a varireb, (c) is a partial cross-sectional view showing a state when the filling auxiliary means is actually used, and (d) is a partial cross-sectional view showing a state when operating with an open stopper.

FIGS. 5A and 5B are cross-sectional views of a chemical solution check unit according to the present invention, wherein FIG. 5A shows a state immediately before a check valve body is mounted, and FIG. 5B shows a state in which the check valve body is mounted. Is shown.

FIG. 6 is a graph showing the relationship between the discharge pressure of the chemical injection device and time.

FIG. 7 shows another embodiment of the filling auxiliary means according to the present invention.

FIG. 8 is a cross-sectional view for explaining a conventional technique.

FIG. 9 is a cross-sectional view for explaining a conventional technique. BEST MODE FOR CARRYING OUT THE INVENTION

FIG. 1 is an external appearance 1 view of a drug solution injector having a filling assist function according to an embodiment of the present invention. (The ink container 10 inside the main body case 6 described later, the elastic container 2, etc. are actually visible from the outside, but are indicated by dotted lines for convenience.) As shown in this figure, the chemical liquid injector 1 A tubular elastic container 2 made of, for example, silicone resin or the like, which is inert and elastic, and an injection port 3 for filling the elastic container 2 with a chemical solution; A delivery pipe 4 composed of a synthetic resin tube for sending the drug solution discharged from one end of the elastic container 2 toward the patient is connected to the delivery pipe 4, and a flow rate adjusting device 5 for adjusting the flow rate of the drug solution 5 And a synthetic resin or metal main body case 6 that protects the elastic container 2 and makes the whole or a part transparent, and filling the elastic container 2 with a chemical solution. A chemical liquid filling auxiliary means 7 is provided to assist the work. That.

The chemical liquid filling auxiliary means 7 is constituted by a suction port 8 for making the inside of the main body case 6 a negative pressure, and the inside of the elastic container 2 is provided with a shape holding member 9 (FIG. 2) having a shape at the time of initial expansion. At the free end of the elastic container 2, a columnar indicator 10 that is movable in the axial direction inside the main body case 6 is provided.

In the present embodiment, the main body case 6 is made of synthetic resin, metal, or glass, and includes an injection-side case 6a that is opaque and a cylindrical suction-side case 6b that has transparency. It is joined so that it is airtight by a method such as bonding. . In the present embodiment, the main body case 6 is divided into the injection side case 6a and the suction side case 6b, but may be formed integrally.

FIG. 2 is a cross-sectional view of an apparatus according to an embodiment of the present invention before filling with a chemical solution, and a detailed description will be given below based on this. As shown in this figure, the injection-side case 6a is connected and fixed in a liquid-tight manner to the cylindrical connection tube 11 to which the injection port 3 is mounted, and the delivery line 4, and the liquid solution to the patient. And a shape retaining member 9 having an initial expansion form of the elastic container 2 at the base end of the injection side case 6a extending through a cylindrical fixed column 15 at the base end. Is established. The inlet side case 6 a has a flow passage 16 therein penetrating from the connection cylinder 11 to the shape holding member 9, and an outflow passage penetrating from the flow passage 16 to the discharge port 14. 17 is provided.

In the suction side case 6b, the suction port 8 extends outside the distal end, and a cylindrical tubular storage portion 19 that stores a valve 18 described later extends inside the distal end.

The indicator 10 is made of synthetic resin, metal or glass, and is a columnar part having an outer diameter slightly smaller than the inner diameter of the suction bow I-side case 6b. It can move (slide) in the axial direction. In addition, the indicator 10 is provided with a fixed shaft 20 having a small outer diameter concentric with the outer periphery and an index line 29 (FIG. 1) on the outer periphery. Further, the suction side case 6b is provided with a scale 30 (FIG. 1) that allows the remaining amount of the chemical solution or the filling amount to be confirmed based on the relative positional relationship with the index line 29.

The elastic container 2 is formed so as to cover the outer periphery of each of the fixed columns 15, the shape retaining members 9 in the injection-side case 6 a, and the fixed shaft 20 in the ink container 10. The outer periphery of the fixed column 15 and the fixed shaft 20 is further covered with the fixing tool 21. The fixing tool 21 has a pipe shape, and its inner diameter is set slightly smaller than the outer circumference of the elastic container 2 covering the fixing column 15 and the fixing shaft 20. By covering the elastic container 1, the elastic container 2 is pressed in the diameter direction, and is fixed airtight to the fixed column 15 and the fixed shaft 20. Further, in the present embodiment, the fixing method using the fixing tool 21 is employed, but the fixing may be performed in an airtight manner by a known method such as adhesion.

The filling auxiliary means 7 in the present embodiment will be described with reference to FIGS. 4 (a), (b), (c) and (d). And will be described specifically.

FIG. 4 (a) is a cross-sectional view showing a steady state of the filling auxiliary means 7, and the suction side case 6b has a suction port 8 at the end of which an external thread 22 is extended. The inside of the suction port 8 is provided with a taper 23 sized so that the tip of the syringe can be inserted into it. Through this taper 23, a cylindrical tubular storage portion 19 in a gas communication state is provided. It will be extended. The storage portion 19 has one or a plurality of communication ports 24 provided on the outer peripheral wall thereof, and has a flange 25 protruding into the storage sound 1519 at an end portion. Inside the storage section 19, a knob 18 made of an elastic rubber material is stored. The knob 18 has a frustoconical valve body 18a and a small-diameter cylindrical knob. Acting part 18b. The length of the Norbu body 18a is set to be longer than the distance from the flange 25 to the top surface 19a of the storage section, and the lower end (left end in the figure) is held by the flange 25. And the upper end (right end in the figure) is stored in close contact with the top surface 19a of the storage section. Therefore, in the state of FIG. 4 (a), due to the close contact of the norbu main body 18a on the top surface 19a, communication between the gas on the taper 23 side and the gas in the suction side case 6b is prevented.

Further, the valve action portion 18b is set so as to protrude to the inside of the suction port 8 in the accommodated state, and has a cut groove 18c at its end as shown in FIG. 4 (b). I have.

Due to the configuration of the filling auxiliary means 7, the main body case 6 is depressurized during actual use, for example, as shown in FIG. 4 (c).

That is, by inserting the distal end portion 26 a of the injection cylinder 26 into the taper 23, the outer periphery of the distal end portion 26 a and the taper 23 are airtightly fitted, and A force acts on the end face 26 a of the tip 26 a to push the valve action section 18 b toward the accommodation section 19. The valve 18 made of a flexible material is compressed in the direction of the accommodating portion 19 by the pushing force, and the close contact of the valve body 18a on the top surface 19a is released.

Subsequently, when suction is started by the syringe 26, the groove shown in FIG. 4 (c) passes through the passage indicated by the arrow in FIG. 4C, that is, the communication port 24 passes through the gap between the top surface 19a and the valve body 18a. The gas in the body case 6 moves into the syringe barrel 26 via 1 8c, and as a result Negative pressure is generated in the area 6 (the dotted line in Fig. 2). Further, by withdrawing the syringe cylinder 26 from the suction port 8, the valve 18 restores its close contact with the top surface 19a due to its elasticity, thereby preventing gas communication.

FIG. 4 (d) relates to an open plug 27 described later.

The opening stopper 27 is a stopper formed of synthetic tree Ji, metal, etc., and has a large outer diameter part 27a and an engaging part which is dimensioned substantially the same as the tip part 26a of the syringe barrel. 27b, and the vent hole 27c penetrates along the central axis. The large outer diameter portion 27a is in the shape of a pipe, and is provided with a female screw portion 28 which can be screwed with the male screw portion 22 on the inner periphery. By using the screwing of the male screw part 22 and the female screw part 28, the opening plug 27 is inserted into the taper 23. Then, when the engaging portion 27 b pushes the valve 18, the vent 27 c and the gas communication with the outside are opened. In addition, the screwing allows the opening plug 27 to be fixed to the suction port 8 constantly, and as a result, the open state of the valve 18 can be maintained.

The injection port 3 is used for filling the liquid medicine into the elastic container 2 using a syringe or the like, and may have any function as a normally used check valve, as shown in FIG. 5 (a). Such a backflow prevention unit 50 may be used (refer to Japanese Patent Application Laid-Open No. 2000-955917). According to this backflow prevention unit, with the insertion cylinder 53 a of the pressing cylinder 53 inserted into the iiih valve body 52 made of a rubber elastic material, the insertion cylinder 53 is inserted into the support cylinder 51, and the locking convex piece 5 is inserted. The backflow prevention unit 50 is formed by fixing with 1 e and the locking recess 53 g.

The backflow prevention unit 50 is fitted into the connection cylinder 11 in the injection case 6a as shown in FIG. 5 (b), and is further formed with a lid 13 integrally formed with the cap 13 (FIG. 1). At the same time that the body 12 is externally fitted to the connecting tube 11, the position is fixed by the wedge effect of the locking convex piece 12a and the annular groove 11a. With such a configuration, the beak-shaped check valve 5 2c of the check valve body 52 allows the flow in the direction of the solid arrow in FIG. 5B, but in the opposite direction (from left to right in the figure). Stop the flow. On the other hand, the annular valve 52b is dimensioned so as to be tightly fitted over the entire circumference at the annular arc edge 51d of the support cylinder 51 in FIG. Dotted arrow direction flow Is allowed within an arbitrary range of pressure change, but in the opposite direction (from right to left in the figure), the flow is stopped.

By using the backflow prevention unit 50 having the above configuration, when the medicinal solution injection device 1 of the present embodiment is filled with the medicinal solution using a syringe or the like, the medicinal solution is filled in the elastic container 2 to prevent backflow. At the same time, the filled drug solution and the air in the elastic container 2 can be evacuated by suction with the syringe.

The flow rate adjusting device 5 adjusts the flow rate of the chemical solution discharged by the contraction force of the elastic container 2. For example, by using a flow control device as disclosed in Japanese Patent Application Laid-Open No. 2000-147777, the drug solution in the elastic container 2 can be selectively injected into a patient. The chemical liquid injector 1 having the above configuration will be described in detail with reference to FIGS.

The first procedure of the liquid injector 1 is to create a negative pressure from the suction port 8 into the main body case 6 (dotted portion in Fig. 2) using a syringe. Since the inside is still at atmospheric pressure, the elastic container 2 tries to expand in the direction of the arrow in FIG. That is, the pushing force of the pusher of the injection cylinder performed by the doctor when filling the elastic container 2 with the drug solution is remarkably reduced.

Furthermore, by connecting the syringe filled with the drug solution to the injection port 3 and forming a negative pressure sufficient to generate the self-expanding force of the elastic container 2 according to the above procedure, the drug solution in the syringe is The device is automatically filled.

As a second procedure, when a predetermined drug solution is filled from the injection port 3 using an injection tube, the elastic container 2 starts to expand as shown in FIG. 3, and the ink container 10 moves backward (to the right in the figure). Moving. Fig. 1 shows a view of the appearance of the bowl at this time.Indicator Itoizumi 29 moves at the same time as the movement of Injike 10 is relative to the scale 30 of the suction case J b 6b. Can be used to determine the filling amount.

As a third procedure, the negative pressure in the main body case 6 is released by attaching the above-described opening plug 27 shown in FIG. 3 to the suction port 8. Then, the chemical solution in the elastic container 2 is pushed out to the delivery pipe 4 via the flow path 16 and the outflow path 17 by the stretching force, and the flow rate provided downstream of the delivery pipe 4 The flow rate is adjusted to a predetermined value via the regulator 5 (Fig. 1) and injected into the patient. The chemical solution discharged according to the above procedure is marked by a solid line in FIG. 6 because the shape retaining member 9 is installed to prevent the elastic container 2 from suddenly changing its shape immediately before the end of the injection. Enter pressure line.

If the chemical liquid filling auxiliary means 7 in the above embodiment is a cock 31 that can be opened and closed as shown in FIG. 7, the work during negative pressure formation can be reduced, and the opening plug 27 in the above embodiment is not required, and the cost can be reduced. Is also obtained.

In addition, in the above embodiment, a syringe was used as a means for forming a shadow, but the use of a vacuum pipe that is permanently installed in a hospital facility reduces the burden on the medical staff. Furthermore, if the negative pressure in the stippling part in Fig. 2 is created in advance (at the time of shipment), the negative pressure creating operation itself becomes unnecessary. Industrial applicability

ADVANTAGE OF THE INVENTION The medical-solution injection | pouring apparatus of this invention can reduce the pressing force at the time of a medical worker filling a medical solution into an elastic container, and can reduce the burden on the user of the said apparatus.

Claims

The scope of the claims

1. A drug solution injection device for injecting a drug solution filled in a tubular elastic container into a patient, wherein an injection port for injecting the drug solution into the elastic container and one end of the elastic container. It is provided with a delivery pipe for delivering the ejected drug solution to the patient, further provided with a main body case for protecting the elastic container, and a drug solution filling assisting device for assisting the filling operation of the drug solution. Liquid injector.

2. The chemical liquid filling operation is assisted by a relative pressure difference between the inside of the elastic container and the inside of the elastic container, which is generated by the chemical liquid filling auxiliary means making the inside of the main body case a negative pressure. The drug solution injection device according to the above.

3. The relative pressure difference between the inside of the main body case and the elastic container in the filling auxiliary means is set to a differential pressure sufficient to generate a self-expanding force of the elastic container. 3. A chemical liquid injector according to claim 2, wherein:

4. The chemical injection according to any one of claims 1 to 3, wherein a shape maintaining member having a shape at the time of initial expansion in the elastic container is provided in the elastic container.

5. At the free end of the stretchable container, an indicator that allows the inside of the main body case to move in the axial direction is provided so that the behavior of the indicator can be checked from the outside of the main body case. The drug solution injector according to any one of claims 1 to 4, wherein a remaining amount or a filling amount of the drug solution in the elastic container can be calculated from a relative position.