WO2003029882A3 - Method and device for sampling part of a light beam, particularly for a fluorescence analysis apparatus - Google Patents

Method and device for sampling part of a light beam, particularly for a fluorescence analysis apparatus Download PDF

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Publication number
WO2003029882A3
WO2003029882A3 PCT/FR2002/003337 FR0203337W WO03029882A3 WO 2003029882 A3 WO2003029882 A3 WO 2003029882A3 FR 0203337 W FR0203337 W FR 0203337W WO 03029882 A3 WO03029882 A3 WO 03029882A3
Authority
WO
WIPO (PCT)
Prior art keywords
order
modulator
fluorescence analysis
light beam
analysis apparatus
Prior art date
Application number
PCT/FR2002/003337
Other languages
French (fr)
Other versions
WO2003029882A2 (en
Inventor
Philippe Peltie
Olivier Peyssonneaux
Raymond Campagnolo
Original Assignee
Commissariat Energie Atomique
Philippe Peltie
Olivier Peyssonneaux
Raymond Campagnolo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Philippe Peltie, Olivier Peyssonneaux, Raymond Campagnolo filed Critical Commissariat Energie Atomique
Publication of WO2003029882A2 publication Critical patent/WO2003029882A2/en
Publication of WO2003029882A3 publication Critical patent/WO2003029882A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/29—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the position or the direction of light beams, i.e. deflection
    • G02F1/33—Acousto-optical deflection devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The invention relates to a method and device for sampling part of a light beam, particularly for a fluorescence analysis apparatus. According to the invention, at least one acousto-optic modulator (30) is positioned on the path of the beam and said modulator is activated in order to produce a diffracted beam (38) of the order of +1 or 1. The latter diffracted beam is subsequently sent to an optical apparatus (A) which only receives said beam when the modulator is activated. In this way, the modulator forms a shutter with respect to the apparatus. The aforementioned apparatus is intended to take measurements and the beam of the order of 0 is used as the reference beam in order to correct said measurements.
PCT/FR2002/003337 2001-10-04 2002-10-01 Method and device for sampling part of a light beam, particularly for a fluorescence analysis apparatus WO2003029882A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR01/12757 2001-10-04
FR0112757A FR2830629B1 (en) 2001-10-04 2001-10-04 METHOD AND DEVICE FOR COLLECTING A PART OF A BRIGHT BEAM, IN PARTICULAR FOR A FLUORESCENCE ANALYSIS APPARATUS

Publications (2)

Publication Number Publication Date
WO2003029882A2 WO2003029882A2 (en) 2003-04-10
WO2003029882A3 true WO2003029882A3 (en) 2004-02-26

Family

ID=8867906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/003337 WO2003029882A2 (en) 2001-10-04 2002-10-01 Method and device for sampling part of a light beam, particularly for a fluorescence analysis apparatus

Country Status (2)

Country Link
FR (1) FR2830629B1 (en)
WO (1) WO2003029882A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12038372B2 (en) 2023-05-17 2024-07-16 Becton, Dickinson And Company Multi-modal fluorescence imaging flow cytometry system

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110290A1 (en) 2013-01-09 2014-07-17 The Regents Of The University Of California Apparatus and methods for fluorescence imaging using radiofrequency-multiplexed excitation
EP3120130B1 (en) 2014-03-18 2023-07-26 The Regents of the University of California Parallel flow cytometer using radiofrequency mulitplexing, and method
AU2016339956B2 (en) 2015-10-13 2021-07-01 Omega Biosystems Incorporated Multi-modal fluorescence imaging flow cytometry system
CN109564151B (en) 2016-03-17 2023-01-24 贝克顿·迪金森公司 Cell sorting using high throughput fluorescence flow cytometer
KR102381176B1 (en) 2016-05-12 2022-04-01 비디 바이오사이언시스 Fluorescence Imaging Flow Cytometry with Improved Image Resolution
EP4242631A3 (en) 2016-09-13 2024-03-06 Becton, Dickinson and Company Flow cytometer with optical equalization
CN114303050A (en) 2019-07-10 2022-04-08 贝克顿·迪金森公司 Reconfigurable integrated circuit for adjusting cell sorting classification
CN116209888A (en) 2020-05-19 2023-06-02 贝克顿·迪金森公司 Method for modulating intensity distribution of laser beam and system thereof
US11680889B2 (en) 2020-06-26 2023-06-20 Becton, Dickinson And Company Dual excitation beams for irradiating a sample in a flow stream and methods for using same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56123521A (en) * 1980-03-05 1981-09-28 Ricoh Co Ltd Optical scanner
JPS59142524A (en) * 1983-02-03 1984-08-15 Fuji Xerox Co Ltd Laser exposing device
JPH02125764A (en) * 1988-11-04 1990-05-14 Konica Corp Quantity-of-light stabilizing light source device
US6210973B1 (en) * 1994-12-05 2001-04-03 John W. Pettit Method for automated flourescent tagged sample detecting
WO2001095026A1 (en) * 2000-06-08 2001-12-13 Brimrose Corporation Of America High speed optical intelligent switch

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56123521A (en) * 1980-03-05 1981-09-28 Ricoh Co Ltd Optical scanner
JPS59142524A (en) * 1983-02-03 1984-08-15 Fuji Xerox Co Ltd Laser exposing device
JPH02125764A (en) * 1988-11-04 1990-05-14 Konica Corp Quantity-of-light stabilizing light source device
US6210973B1 (en) * 1994-12-05 2001-04-03 John W. Pettit Method for automated flourescent tagged sample detecting
WO2001095026A1 (en) * 2000-06-08 2001-12-13 Brimrose Corporation Of America High speed optical intelligent switch

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 005, no. 201 (P - 094) 19 December 1981 (1981-12-19) *
PATENT ABSTRACTS OF JAPAN vol. 008, no. 275 (P - 321) 15 December 1984 (1984-12-15) *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 357 (M - 1005) 2 August 1990 (1990-08-02) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12038372B2 (en) 2023-05-17 2024-07-16 Becton, Dickinson And Company Multi-modal fluorescence imaging flow cytometry system

Also Published As

Publication number Publication date
FR2830629B1 (en) 2004-01-09
FR2830629A1 (en) 2003-04-11
WO2003029882A2 (en) 2003-04-10

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