WO2003029819A1 - Method of screening preventive/remedy for bone/joint diseases - Google Patents

Method of screening preventive/remedy for bone/joint diseases Download PDF

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Publication number
WO2003029819A1
WO2003029819A1 PCT/JP2002/009949 JP0209949W WO03029819A1 WO 2003029819 A1 WO2003029819 A1 WO 2003029819A1 JP 0209949 W JP0209949 W JP 0209949W WO 03029819 A1 WO03029819 A1 WO 03029819A1
Authority
WO
WIPO (PCT)
Prior art keywords
remedy
bone
joint diseases
screening
preventive
Prior art date
Application number
PCT/JP2002/009949
Other languages
French (fr)
Japanese (ja)
Inventor
Koji Yoshimura
Yuichi Hikichi
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of WO2003029819A1 publication Critical patent/WO2003029819A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins

Abstract

As a method of screening a preventive/remedy for bone/joint diseases, a method of screening a compound or its salt promoting or inhibiting the decomposition of proteoglycan characterized by using cells expressing both of MMP-19 and MT3-MMP is provided.
PCT/JP2002/009949 2001-09-28 2002-09-26 Method of screening preventive/remedy for bone/joint diseases WO2003029819A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-303314 2001-09-28
JP2001303314 2001-09-28

Publications (1)

Publication Number Publication Date
WO2003029819A1 true WO2003029819A1 (en) 2003-04-10

Family

ID=19123415

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009949 WO2003029819A1 (en) 2001-09-28 2002-09-26 Method of screening preventive/remedy for bone/joint diseases

Country Status (1)

Country Link
WO (1) WO2003029819A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1080283A (en) * 1996-04-25 1998-03-31 Takeda Chem Ind Ltd New protein and its dna
WO2001049309A2 (en) * 1999-12-29 2001-07-12 Pfizer Limited Combinations of growth factors and i: upa or i: mmp for the treatment of damaged tissue
WO2001066766A2 (en) * 2000-03-06 2001-09-13 Darwin Molecular Corporation A matrix metalloproteinase (mmp-25) expressed in skin cell

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1080283A (en) * 1996-04-25 1998-03-31 Takeda Chem Ind Ltd New protein and its dna
WO2001049309A2 (en) * 1999-12-29 2001-07-12 Pfizer Limited Combinations of growth factors and i: upa or i: mmp for the treatment of damaged tissue
WO2001066766A2 (en) * 2000-03-06 2001-09-13 Darwin Molecular Corporation A matrix metalloproteinase (mmp-25) expressed in skin cell

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TAKAHISA T. ET AL.: "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library", J. BIOL. CHEM., vol. 270, no. 39, 29 September 1995 (1995-09-29), pages 23013 - 23020, XP002925884 *

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