WO2003026635A3 - Procede ameliore de traitement du syndrome du diabete de type 2 chez les humains - Google Patents
Procede ameliore de traitement du syndrome du diabete de type 2 chez les humains Download PDFInfo
- Publication number
- WO2003026635A3 WO2003026635A3 PCT/US2002/018419 US0218419W WO03026635A3 WO 2003026635 A3 WO2003026635 A3 WO 2003026635A3 US 0218419 W US0218419 W US 0218419W WO 03026635 A3 WO03026635 A3 WO 03026635A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diabetes
- syndrome
- treating
- type
- opiates
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/878,751 US20020045572A1 (en) | 2000-08-15 | 2001-06-11 | Method of treating the syndrome of type 2 diabetes in humans |
US09/878,751 | 2001-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003026635A2 WO2003026635A2 (fr) | 2003-04-03 |
WO2003026635A3 true WO2003026635A3 (fr) | 2004-04-01 |
Family
ID=25372756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/018419 WO2003026635A2 (fr) | 2001-06-11 | 2002-06-11 | Procede ameliore de traitement du syndrome du diabete de type 2 chez les humains |
Country Status (2)
Country | Link |
---|---|
US (1) | US20020045572A1 (fr) |
WO (1) | WO2003026635A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8969288B2 (en) | 2008-12-19 | 2015-03-03 | Indiana University Research And Technology Corporation | Amide based glucagon and superfamily peptide prodrugs |
US9156902B2 (en) | 2011-06-22 | 2015-10-13 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6528520B2 (en) | 2000-08-15 | 2003-03-04 | Cpd, Llc | Method of treating the syndrome of coronary heart disease risk factors in humans |
US6846831B2 (en) | 2000-08-15 | 2005-01-25 | Cpd, Llc | Method of treating the syndrome of lipodystrophy |
DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
CA2628241C (fr) | 2005-11-07 | 2016-02-02 | Indiana University Research And Technology Corporation | Analogues de glucagon a solubilite et a stabilite physiologiques ameliorees |
PT2001456E (pt) * | 2006-04-04 | 2010-03-03 | Emodys Gmbh | Utilização de composições contendo antagonistas dos receptores opióides kappa no tratamento de distúrbios dissociativos |
SI2724722T1 (sl) | 2006-10-20 | 2017-07-31 | Neurendo Pharma, Llc | Postopek za obnovitev učinka inkretina |
AU2008205229B2 (en) | 2007-01-05 | 2014-03-27 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological pH buffers |
KR20150116465A (ko) | 2007-02-15 | 2015-10-15 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루카곤/glp-1 수용체 공동-항진물질 |
CA2702289A1 (fr) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Composes presentant une activite d'antagoniste de glucagon et d'agoniste du glp-1 |
CA2707861A1 (fr) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Antagonistes du glucagon |
WO2009073627A1 (fr) * | 2007-11-30 | 2009-06-11 | The Research Foundation Of State University Of New York | Biomarqueur de remplacement de combustible métabolique |
JP5753779B2 (ja) | 2008-06-17 | 2015-07-22 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | 生理学的pHの緩衝液中で向上した溶解性及び安定性を示すグルカゴン類縁体 |
NZ589847A (en) | 2008-06-17 | 2013-01-25 | Univ Indiana Res & Tech Corp | Glucagon/glp-1 receptor co-agonists |
EP2952202B1 (fr) | 2008-06-17 | 2017-10-18 | Indiana University Research and Technology Corporation | Agonistes mixtes basés sur gip destinés au traitement de troubles métaboliques et de l'obésité |
KR20120087875A (ko) | 2009-06-16 | 2012-08-07 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | Gip 수용체-활성 글루카곤 화합물 |
EP2512503A4 (fr) | 2009-12-18 | 2013-08-21 | Univ Indiana Res & Tech Corp | Co-agonistes du récepteur du glucagon/glp-i |
MX2012008603A (es) | 2010-01-27 | 2013-01-25 | Univ Indiana Res & Tech Corp | Conjugados de antagonista de glucagon-agonista de gip y composiciones para el tratamiento de desordenes metabolicos y obesidad. |
CA2797095A1 (fr) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Peptides de la superfamille des glucagons presentant une activite de recepteur nucleaire d'hormone |
CA2797089A1 (fr) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Peptides de la superfamille du glucagon manifestant une activite de recepteur couple a une proteine g |
WO2011163012A2 (fr) | 2010-06-24 | 2011-12-29 | Indiana University Research And Technology Corporation | Promédicaments peptidiques à base d'amides de la superfamille du glucagon |
BR112013015389A2 (pt) | 2010-12-22 | 2016-11-22 | Univ Indiana Res & Tech Corp | análogo de glucagon exibindo atividade de receptor gip |
RU2014101697A (ru) | 2011-06-22 | 2015-07-27 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Коагонисты рецепторов глюкагона/glp-1 |
KR20130017859A (ko) * | 2011-08-12 | 2013-02-20 | 솔젠트 (주) | 피니톨과 약물을 포함하는 당뇨병 치료용 병용제 |
RU2014117678A (ru) | 2011-11-17 | 2015-12-27 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Пептиды глюкагонового суперсемейства, обладающие глюкокортикоидной рецепторной активностью |
EP2864351B1 (fr) | 2012-06-21 | 2016-08-10 | Indiana University Research and Technology Corporation | Analogues du glucagon présentant une activité sur le récepteur du gip |
KR20140027594A (ko) * | 2012-07-23 | 2014-03-07 | 씨지케이바이오 주식회사 | 항당뇨 및 항비만 활성을 갖는 약학 조성물 |
EP3215154B1 (fr) | 2014-11-07 | 2020-01-29 | Regents of the University of Minnesota | Sels et compositions utiles pour le traitement de maladie |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997035608A1 (fr) * | 1996-03-22 | 1997-10-02 | The University Of Birmingham | Traitement du diabete |
WO2002100390A2 (fr) * | 2001-06-11 | 2002-12-19 | Cpd Llc | Methode amelioree de traitement du syndrome des facteurs de risque de coronaropathie chez l'etre humain |
-
2001
- 2001-06-11 US US09/878,751 patent/US20020045572A1/en not_active Abandoned
-
2002
- 2002-06-11 WO PCT/US2002/018419 patent/WO2003026635A2/fr not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997035608A1 (fr) * | 1996-03-22 | 1997-10-02 | The University Of Birmingham | Traitement du diabete |
WO2002100390A2 (fr) * | 2001-06-11 | 2002-12-19 | Cpd Llc | Methode amelioree de traitement du syndrome des facteurs de risque de coronaropathie chez l'etre humain |
Non-Patent Citations (15)
Title |
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AHREN B: "Effects of [beta]-endorphin, met-enkephalin, and dynorphin A on basal and stimulated insulin secretion in the mouse", INTERNATIONAL JOURNAL OF PANCREATOLOGY 1989 UNITED STATES, vol. 5, no. 2, 1989, pages 165 - 178, XP008023242, ISSN: 0169-4197 * |
BERKOW R.; FLETCHER A.J (EDS.).: "MERCK MANUAL OF DIAGNOSIS AND THERAPY (17th Ed.)", 1999, MERCK RESEARCH LABORATORIES, NEW JERSEY, XP002257951, 236240 * |
BIOCHIMICA ET BIOPHYSICA ACTA. NETHERLANDS 19 SEP 1986, vol. 888, no. 2, 19 September 1986 (1986-09-19), pages 217 - 224, ISSN: 0006-3002 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AHLGREN, GUNNAR: "Insulin -like action of morphine and certain morphine derivatives", XP002257953, accession no. STN Database accession no. 24:20275 * |
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1982, GIUGLIANO D ET AL: "Impaired insulin secretion in human diabetes mellitus. The effect of naloxone-induced opiate receptor blockade", XP002257628, Database accession no. EMB-1982097228 * |
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1987, GIUGLIANO D ET AL: "[beta]-Endorphin and islet hormone release in type-2 diabetes mellitus. The effects of normoglycemia, enkephalin, naloxone and somatostatin", XP002257952, Database accession no. EMB-1988087121 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 19 September 1986 (1986-09-19), VERSPOHL E J ET AL: "The significance of mu- and delta-receptors in rat pancreatic islets for the opioid-mediated insulin release.", XP002257627, Database accession no. NLM2874836 * |
DIABETE ET METABOLISME 1987 FRANCE, vol. 13, no. 6, 1987, pages 618 - 624, ISSN: 0338-1684 * |
DIABETES 1982 UNITED STATES, vol. 31, no. 4, 1982, pages 367 - 370 * |
GOT I ET AL: "Medical treatment in diabetic patients with peripheral occlusive arterial disease", JOURNAL DES MALADIES VASCULAIRES 1993 FRANCE, vol. 18, no. 1, 1993, pages 30 - 36, XP008023367, ISSN: 0398-0499 * |
GUPTA B ET AL: "GLUCOSE HOMEOSTATIS AND DRUGS ACTING ON CNS: INTERACTIONS WITH ANTIDIABETIC AGENTS", INDIAN JOURNAL OF PHARMACOLOGY, XX, XX, vol. 26, no. 3, 1994, pages 169 - 178, XP008022532, ISSN: 0253-7613 * |
KHAWAJA X Z ET AL: "Increased sensitivity to insulin-releasing and glucoregulatory effects of dynorphin A1-13 and U 50488h in ob/ob versus lean mice", DIABETES 1990 UNITED STATES, vol. 39, no. 10, 1990, pages 1289 - 1297, XP008023244, ISSN: 0012-1797 * |
LESLIE R D G ET AL: "SENSITIVITY TO ENKEPHALIN AS A CAUSE OF NON-INSULIN DEPENDENT DIABETES", LANCET, LITTLE, BROWM AND CO., BOSTON,, US, no. 8112, 17 January 1979 (1979-01-17), pages 341 - 343, XP008022453, ISSN: 0099-5355 * |
SACHSE G ET AL: "OPIATES INFLUENCE ENDOCRINE PANCREAS SECRETION", DIABETOLOGIA, BERLIN, DE, vol. 21, no. 3, 1981, pages 444, XP008022526, ISSN: 0012-186X * |
SKANDINAVISCHES ARCHIV FUER PHYSIOLOGIE (1930), 58, 153-72 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8969288B2 (en) | 2008-12-19 | 2015-03-03 | Indiana University Research And Technology Corporation | Amide based glucagon and superfamily peptide prodrugs |
US9156902B2 (en) | 2011-06-22 | 2015-10-13 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
Also Published As
Publication number | Publication date |
---|---|
WO2003026635A2 (fr) | 2003-04-03 |
US20020045572A1 (en) | 2002-04-18 |
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