WO2003026577A3 - P-amidobenzylethers in drug delivery agents - Google Patents

P-amidobenzylethers in drug delivery agents Download PDF

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Publication number
WO2003026577A3
WO2003026577A3 PCT/US2002/030282 US0230282W WO03026577A3 WO 2003026577 A3 WO2003026577 A3 WO 2003026577A3 US 0230282 W US0230282 W US 0230282W WO 03026577 A3 WO03026577 A3 WO 03026577A3
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WO
WIPO (PCT)
Prior art keywords
compounds
amidobenzylethers
drug delivery
delivery agents
group
Prior art date
Application number
PCT/US2002/030282
Other languages
French (fr)
Other versions
WO2003026577A2 (en
Inventor
Peter D Senter
Brian E Toki
Original Assignee
Seattle Genetics Inc
Peter D Senter
Brian E Toki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/963,103 external-priority patent/US7091186B2/en
Application filed by Seattle Genetics Inc, Peter D Senter, Brian E Toki filed Critical Seattle Genetics Inc
Priority to AU2002339993A priority Critical patent/AU2002339993A1/en
Publication of WO2003026577A2 publication Critical patent/WO2003026577A2/en
Publication of WO2003026577A3 publication Critical patent/WO2003026577A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the fonnulas L-[-An-Z-X-Ww-]-D and B-[-Z-X-Ww-]-D, wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and/or excipient, and methods of delivery the drug D via the compounds.
PCT/US2002/030282 2001-09-24 2002-09-24 P-amidobenzylethers in drug delivery agents WO2003026577A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002339993A AU2002339993A1 (en) 2001-09-24 2002-09-24 P-amidobenzylethers in drug delivery agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/963,103 2001-09-24
US09/963,103 US7091186B2 (en) 2001-09-24 2001-09-24 p-Amidobenzylethers in drug delivery agents
US10/252,947 US7553816B2 (en) 2001-09-24 2002-09-23 p-amidobenzylethers in drug delivery agents
US10/252,947 2002-09-23

Publications (2)

Publication Number Publication Date
WO2003026577A2 WO2003026577A2 (en) 2003-04-03
WO2003026577A3 true WO2003026577A3 (en) 2004-09-16

Family

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Family Applications (1)

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PCT/US2002/030282 WO2003026577A2 (en) 2001-09-24 2002-09-24 P-amidobenzylethers in drug delivery agents

Country Status (1)

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WO (1) WO2003026577A2 (en)

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