WO2003022308A3 - Therapeutic insert and therapeutic method - Google Patents

Therapeutic insert and therapeutic method Download PDF

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Publication number
WO2003022308A3
WO2003022308A3 PCT/GB2002/004185 GB0204185W WO03022308A3 WO 2003022308 A3 WO2003022308 A3 WO 2003022308A3 GB 0204185 W GB0204185 W GB 0204185W WO 03022308 A3 WO03022308 A3 WO 03022308A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
implant
therapeutic
radiotherapy
insert
Prior art date
Application number
PCT/GB2002/004185
Other languages
French (fr)
Other versions
WO2003022308A2 (en
Inventor
Nicholas Miller
Miles William Noel Hember
Original Assignee
Scient Generics Ltd
Nicholas Miller
Miles William Noel Hember
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0122152A external-priority patent/GB0122152D0/en
Priority claimed from GB0122175A external-priority patent/GB0122175D0/en
Application filed by Scient Generics Ltd, Nicholas Miller, Miles William Noel Hember filed Critical Scient Generics Ltd
Priority to AU2002324193A priority Critical patent/AU2002324193A1/en
Publication of WO2003022308A2 publication Critical patent/WO2003022308A2/en
Publication of WO2003022308A3 publication Critical patent/WO2003022308A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/048—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A61N1/406—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia using implantable thermoseeds or injected particles for localized hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A thin preformed therapeutic implant contains minute particles, and has a polymeric material at least on the outside. The particles may be radioactive for radiotherapy, radio-opaque for easy imaging, and ferromagnetic for thermal therapy, and are preferably ferrite particles. The particles and the implant as a whole may be biodegradable, and drugs or other chemicals may be associated with the particles or otherwise combined in the implant to allow combination therapies. The implant may be in the form of seeds, a filament, a ribbon or a sheet, and therapeutic performance can be tailored by a non-uniform distribution of particles in the implant. The ferrite particles can be used in localised heat therapy either in the implants or separately, to provide a combination of heat therapy with radiotherapy and/or chemotherapy.
PCT/GB2002/004185 2001-09-13 2002-09-13 Therapeutic insert and therapeutic method WO2003022308A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002324193A AU2002324193A1 (en) 2001-09-13 2002-09-13 Therapeutic insert and therapeutic method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0122152.2 2001-09-13
GB0122152A GB0122152D0 (en) 2001-09-13 2001-09-13 Radioactive seeds
GB0122175A GB0122175D0 (en) 2001-09-13 2001-09-13 Combination therapy using multifunctional particle
GB0122175.3 2001-09-13

Publications (2)

Publication Number Publication Date
WO2003022308A2 WO2003022308A2 (en) 2003-03-20
WO2003022308A3 true WO2003022308A3 (en) 2003-05-30

Family

ID=26246538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/004185 WO2003022308A2 (en) 2001-09-13 2002-09-13 Therapeutic insert and therapeutic method

Country Status (2)

Country Link
AU (1) AU2002324193A1 (en)
WO (1) WO2003022308A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018107425B4 (en) 2018-03-28 2022-12-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for stimulating a tissue structure using an electric field strength, system for stimulating a tissue structure and magnet structure for implanting in a tissue structure

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502998A1 (en) * 1985-01-30 1986-07-31 Detlef Dr. 5100 Aachen Müller-Schulte Compositions for selective tumour therapy and processes for the preparation and use thereof
EP0361797A1 (en) * 1988-09-26 1990-04-04 Kyoto University Heat-generating ceramics body for hyperthermia and method of producing the same
WO1993005815A1 (en) * 1991-09-16 1993-04-01 Syngenix Limited Synthetic transfection vectors
DE4427821A1 (en) * 1993-03-17 1996-02-01 Silica Gel Gmbh Stabilised super-paramagnetic aggregate particles
WO1996003112A1 (en) * 1993-05-04 1996-02-08 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
WO2001013949A2 (en) * 1999-08-19 2001-03-01 Magforce Applications Gmbh Medical preparation for treating arthrosis, arthritis and other rheumatic joint diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3502998A1 (en) * 1985-01-30 1986-07-31 Detlef Dr. 5100 Aachen Müller-Schulte Compositions for selective tumour therapy and processes for the preparation and use thereof
EP0361797A1 (en) * 1988-09-26 1990-04-04 Kyoto University Heat-generating ceramics body for hyperthermia and method of producing the same
WO1993005815A1 (en) * 1991-09-16 1993-04-01 Syngenix Limited Synthetic transfection vectors
DE4427821A1 (en) * 1993-03-17 1996-02-01 Silica Gel Gmbh Stabilised super-paramagnetic aggregate particles
WO1996003112A1 (en) * 1993-05-04 1996-02-08 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
WO2001013949A2 (en) * 1999-08-19 2001-03-01 Magforce Applications Gmbh Medical preparation for treating arthrosis, arthritis and other rheumatic joint diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JORDAN A ET AL: "Inductive heating of ferrimagnetic particles and magnetic fluids: Physical evaluation of their potential for hyperthermia", INTERNATIONAL JOURNAL OF HYPERTHERMIA 1993 UNITED KINGDOM, vol. 9, no. 1, 1993, pages 51 - 68, XP008015370, ISSN: 0265-6736 *

Also Published As

Publication number Publication date
AU2002324193A1 (en) 2003-03-24
WO2003022308A2 (en) 2003-03-20

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