WO2003018799A3 - Modulators of bone homeostasis identified in a high-throughput screen - Google Patents
Modulators of bone homeostasis identified in a high-throughput screen Download PDFInfo
- Publication number
- WO2003018799A3 WO2003018799A3 PCT/EP2002/009530 EP0209530W WO03018799A3 WO 2003018799 A3 WO2003018799 A3 WO 2003018799A3 EP 0209530 W EP0209530 W EP 0209530W WO 03018799 A3 WO03018799 A3 WO 03018799A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- relates
- present
- throughput screen
- methods
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002457879A CA2457879A1 (en) | 2001-08-22 | 2002-08-22 | Modulators of bone homeostasis identified in a high-throughput screen |
JP2003523648A JP2005503792A (en) | 2001-08-22 | 2002-08-22 | Bone homeostasis modulator identified in high-throughput screening |
EP02796279A EP1438402A2 (en) | 2001-08-22 | 2002-08-22 | Modulators of bone homeostasis identified in a high-throughput screen |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31405601P | 2001-08-22 | 2001-08-22 | |
US60/314,056 | 2001-08-22 | ||
EP01870181 | 2001-08-22 | ||
EP01870181.3 | 2001-08-22 | ||
US35693502P | 2002-02-14 | 2002-02-14 | |
US60/356,935 | 2002-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003018799A2 WO2003018799A2 (en) | 2003-03-06 |
WO2003018799A3 true WO2003018799A3 (en) | 2004-03-11 |
Family
ID=56290324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/009530 WO2003018799A2 (en) | 2001-08-22 | 2002-08-22 | Modulators of bone homeostasis identified in a high-throughput screen |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1438402A2 (en) |
JP (1) | JP2005503792A (en) |
CA (1) | CA2457879A1 (en) |
WO (1) | WO2003018799A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003300239A1 (en) | 2003-12-29 | 2005-07-21 | Galapagos Genomics N.V. | Modulators of bone homeostasis identified in a high-throughput screen |
WO2005124343A2 (en) * | 2004-06-16 | 2005-12-29 | Galapagos N.V. | Methods for modulating bone tissue formation, orthogenic agents and pharmaceutical compositions |
WO2005124342A2 (en) | 2004-06-21 | 2005-12-29 | Galapagos N.V. | Methods and means for treatment of osteoarthritis |
US7906116B2 (en) | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
AU2009313560B2 (en) | 2008-11-07 | 2016-04-14 | Fabrus Llc | Combinatorial antibody libraries and uses thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998005775A1 (en) * | 1996-08-01 | 1998-02-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Gene involved in cadasil, method of diagnosis and therapeutic application |
WO1998039446A2 (en) * | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 70 human secreted proteins |
WO1998045434A1 (en) * | 1997-04-04 | 1998-10-15 | Millennium Biotherapeutics, Inc. | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
WO1999064582A2 (en) * | 1998-06-12 | 1999-12-16 | Introgene B.V. | High-throughput screening of gene function using libraries for functional genomics applications |
WO2000006726A2 (en) * | 1998-07-27 | 2000-02-10 | Amgen Inc. | Delta-related polypeptides |
EP1004669A1 (en) * | 1997-05-14 | 2000-05-31 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel differentiation inhibitor |
-
2002
- 2002-08-22 WO PCT/EP2002/009530 patent/WO2003018799A2/en not_active Application Discontinuation
- 2002-08-22 CA CA002457879A patent/CA2457879A1/en not_active Abandoned
- 2002-08-22 EP EP02796279A patent/EP1438402A2/en not_active Withdrawn
- 2002-08-22 JP JP2003523648A patent/JP2005503792A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998005775A1 (en) * | 1996-08-01 | 1998-02-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Gene involved in cadasil, method of diagnosis and therapeutic application |
WO1998039446A2 (en) * | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 70 human secreted proteins |
WO1998045434A1 (en) * | 1997-04-04 | 1998-10-15 | Millennium Biotherapeutics, Inc. | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
EP1004669A1 (en) * | 1997-05-14 | 2000-05-31 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel differentiation inhibitor |
WO1999064582A2 (en) * | 1998-06-12 | 1999-12-16 | Introgene B.V. | High-throughput screening of gene function using libraries for functional genomics applications |
WO2000006726A2 (en) * | 1998-07-27 | 2000-02-10 | Amgen Inc. | Delta-related polypeptides |
Non-Patent Citations (4)
Title |
---|
DALLAS D.J. ET AL: "Stimulation of osteoblast differentiation and bone formation in vitro and in vivo by Notch receptor-ligand interactions", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 14, no. SUPPL 1, September 1999 (1999-09-01), pages S172, XP002237112, ISSN: 0884-0431 * |
LOU J. ET AL.: "Gene therapy: adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo", JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 17, no. 1, January 1999 (1999-01-01), pages 43 - 50, XP002194122 * |
SHUTTER J.R. ET AL.: "Dll4, a novel Notch ligand expressed in arterial endothelium", GENES & DEVELOPMENT, vol. 14, no. 11, 1 June 2000 (2000-06-01), pages 1313 - 1318, XP002237111 * |
TEZUKA K. ET AL.: "Actions of Notch on osteoblastic and chondrogenic cell differentiation", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 15, no. Suppl.1, September 2000 (2000-09-01), pages S217, XP008015904 * |
Also Published As
Publication number | Publication date |
---|---|
CA2457879A1 (en) | 2003-03-06 |
WO2003018799A2 (en) | 2003-03-06 |
JP2005503792A (en) | 2005-02-10 |
EP1438402A2 (en) | 2004-07-21 |
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