WO2003017972A3 - Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) - Google Patents

Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) Download PDF

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Publication number
WO2003017972A3
WO2003017972A3 PCT/IL2002/000699 IL0200699W WO03017972A3 WO 2003017972 A3 WO2003017972 A3 WO 2003017972A3 IL 0200699 W IL0200699 W IL 0200699W WO 03017972 A3 WO03017972 A3 WO 03017972A3
Authority
WO
WIPO (PCT)
Prior art keywords
peo
thermal gelation
reverse thermal
polymeric systems
component polymeric
Prior art date
Application number
PCT/IL2002/000699
Other languages
French (fr)
Other versions
WO2003017972A8 (en
WO2003017972A2 (en
Inventor
Daniel Cohn
Alejandro Sosnik
Original Assignee
Yissum Res Dev Co
Daniel Cohn
Alejandro Sosnik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL15128802A external-priority patent/IL151288A0/en
Application filed by Yissum Res Dev Co, Daniel Cohn, Alejandro Sosnik filed Critical Yissum Res Dev Co
Priority to AU2002321818A priority Critical patent/AU2002321818A1/en
Publication of WO2003017972A2 publication Critical patent/WO2003017972A2/en
Publication of WO2003017972A3 publication Critical patent/WO2003017972A3/en
Publication of WO2003017972A8 publication Critical patent/WO2003017972A8/en
Priority to US10/789,431 priority patent/US20050008609A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

The invention provides a multi-component environmentally responsive polymeric system (e.g block copolymer comprising PEO and PPO), comprising at least two environmentally responsive polymeric components capable of undergoing a transition that results in a sharp increase in viscosity in response to a change in temperature at a predetermined body site, wherein said at least two components display different reverse thermal gelation behavior.
PCT/IL2002/000699 2001-08-27 2002-08-22 Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) WO2003017972A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002321818A AU2002321818A1 (en) 2001-08-27 2002-08-22 Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)
US10/789,431 US20050008609A1 (en) 2001-08-27 2004-02-27 Multi-component reverse thermo-sensitive polymeric systems

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31464001P 2001-08-27 2001-08-27
US60/314,640 2001-08-27
IL15128802A IL151288A0 (en) 2001-08-27 2002-08-15 Multi-component reverse thermo-sensitive polymeric systems
IL151288 2002-08-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/789,431 Continuation US20050008609A1 (en) 2001-08-27 2004-02-27 Multi-component reverse thermo-sensitive polymeric systems

Publications (3)

Publication Number Publication Date
WO2003017972A2 WO2003017972A2 (en) 2003-03-06
WO2003017972A3 true WO2003017972A3 (en) 2003-10-02
WO2003017972A8 WO2003017972A8 (en) 2003-11-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000699 WO2003017972A2 (en) 2001-08-27 2002-08-22 Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)

Country Status (2)

Country Link
AU (1) AU2002321818A1 (en)
WO (1) WO2003017972A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1023720C2 (en) * 2003-06-23 2004-12-28 Univ Eindhoven Tech Method for changing the transport properties of a material, method for releasing a drug from an implant, as well as implant with drug.
US8217219B2 (en) 2003-12-29 2012-07-10 Kimberly-Clark Worldwide, Inc. Anatomically conforming vaginal insert
KR20110010783A (en) * 2008-06-18 2011-02-07 에프. 호프만-라 로슈 아게 Aryl ketone as mri
WO2011007352A2 (en) 2009-07-13 2011-01-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Intraluminal polymeric devices for the treatment of aneurysms
DE102012223416A1 (en) * 2012-12-17 2014-07-03 Polymaterials Ag Chain extended poloxamers, thermoreversible hydrogels formed therefrom with biological materials, and medical applications thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010849A1 (en) * 1995-09-21 1997-03-27 Sam Yang Co., Ltd. Copolymeric micelle drug composition and method for the preparation thereof
WO2000066085A1 (en) * 1999-04-29 2000-11-09 Macromed, Inc. A bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
WO2001076558A1 (en) * 2000-04-07 2001-10-18 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
WO2001082970A1 (en) * 2000-04-27 2001-11-08 Macromed, Inc. Mixtures of triblock polyesterpolyethylene glycol copolymers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010849A1 (en) * 1995-09-21 1997-03-27 Sam Yang Co., Ltd. Copolymeric micelle drug composition and method for the preparation thereof
WO2000066085A1 (en) * 1999-04-29 2000-11-09 Macromed, Inc. A bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
WO2001076558A1 (en) * 2000-04-07 2001-10-18 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
WO2001082970A1 (en) * 2000-04-27 2001-11-08 Macromed, Inc. Mixtures of triblock polyesterpolyethylene glycol copolymers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JEONG B ET AL: "BIODEGRADABLE BLOCK COPOLYMERS AS INJECTABLE DRUG-DELIVERY SYSTEMS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 388, no. 6645, 28 August 1997 (1997-08-28), pages 860 - 862, XP002068338, ISSN: 0028-0836 *
MARTINI L ET AL: "MICELLISATION AND GELATION OF TRIBLOCK COPOLYMER OF ETHYLENE OXIDE AND EPSILON-CAPROLACTONE, CLNEMCLN, IN AQUEOUS SOLUTION", JOURNAL OF THE CHEMICAL SOCIETY. FARADAY TRANSACTIONS, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, GB, vol. 90, no. 13, 7 July 1994 (1994-07-07), pages 1961 - 1966, XP000454914, ISSN: 0956-5000 *

Also Published As

Publication number Publication date
AU2002321818A1 (en) 2003-03-10
WO2003017972A8 (en) 2003-11-20
WO2003017972A2 (en) 2003-03-06

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