WO2003017768A2 - Infusion of inula viscosa for controlling hematophagic insects, mosquitos, flies, and horseflies - Google Patents

Infusion of inula viscosa for controlling hematophagic insects, mosquitos, flies, and horseflies Download PDF

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Publication number
WO2003017768A2
WO2003017768A2 PCT/IT2002/000550 IT0200550W WO03017768A2 WO 2003017768 A2 WO2003017768 A2 WO 2003017768A2 IT 0200550 W IT0200550 W IT 0200550W WO 03017768 A2 WO03017768 A2 WO 03017768A2
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WO
WIPO (PCT)
Prior art keywords
infusion
mosquitos
insects
horseflies
flies
Prior art date
Application number
PCT/IT2002/000550
Other languages
French (fr)
Other versions
WO2003017768A3 (en
Inventor
Cosimo Virruso
Original Assignee
Cosimo Virruso
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosimo Virruso filed Critical Cosimo Virruso
Priority to AU2002334400A priority Critical patent/AU2002334400A1/en
Publication of WO2003017768A2 publication Critical patent/WO2003017768A2/en
Publication of WO2003017768A3 publication Critical patent/WO2003017768A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/12Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • insects With the common noun of mosquito are indicated the different species of insects “Dipteron Nematocera” of the family “Culex". They have a thin body which is long from 3 mm to 15 mm, provided with antennas and long and thin legs. The males feed on sugary substance of vegetable origin, while the she- mosquitos need a rich in proteins diet, so they resort to the "feed of blood” preferring as “blood donor” the human specie. Many species are annoying only for the stings, while many others, in addition to the irritation of their stings, can pass pathologies more or less dangerous. The anopheles pass the plasmodium of the malaria, the mosquitos of the genus "aedes” pass the virus of the yellow fever and of the "dengue", for example.
  • the corporal temperature and the transpiration indicate them the point of attack.
  • the mosquitos begin their "feed of blood".
  • the mosquitos provide for drilling of the skin executed by a series of alternate movements of the two jaws, next to which the alimentary duct and the salivary duct, ipopharinx, are situated.
  • the mosquito Inserted her proboscis in the skin of the host, the mosquito injects her saliva which causes a vasodilatation which determines a greater afflux of blood.
  • the saliva of the insect besides to produce an allergic reaction, can insert in the organism of the prey patogenic agents.
  • the fnula Viscosa is a perennial plant of the family of the Composite, a little woody at the base and considerably branched. It is , in full, covered by a velum of grandular and microscopic hairs, which gives her the charatteristic stickiness.
  • the leaves have lanceolate shape, dentate edges, and are sessile, stalkless.
  • the yellow flowers are disposed in flower-head and form long and pyramidal clusters at the extremity of the stalk.
  • This plant which was known in distant times for her antiseptic, antibacterial, hemostatic and cicatrizant properties, to day it is held in esteem for antimycotic properties of her substances. It is largely diffused in Italy, France, Spain, Turkey, Israel.
  • object of this invention have been used parts of plant drawn in the area of Casteldaccia in province of Palermo.
  • Infusion n.l 100 grams of vegetable oil in 50 leaves of Inula Viscosa, in erme tic pot for 48 h at room temperature.
  • Infusion n.2 100 grams of water in 50 leaves of Inula Viscosa, in ermetic pot for 48 h at room temperature.
  • Ir ⁇ fusionn.3 100 grams of ethilic amide in 50 leaves of Inula Viscosa, in ermetic pot for 48 h at room temperature.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Biotechnology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Botany (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention refers to infusions of Inula Viscosa, and a process to obtain the mentioned infusions by treatment with ethyl alcohol, vegetable oil, or water. The infusions show activity against hematophagic insects, mosquitos, flies, and horseflies.

Description

Description of the industrial invention having for title: Infusion of Inula Viscosa having properties against hematophage insects, mosquitos, flies, horseflies. Name: Virruso Cosimo State of nationality: Italia resident in Casteldaccia (Palermo) viaMatteotti n. 5 Summary: the present invention refers to infusion of Inula Viscosa. It concerns the process to obtain the mentioned infusion in bath of ethilic alcool, vegetable oil, water. The liquid obtained from the infusions present a considerable activity against hematophage insects, mosquitos, flies, horseflies. State of the technique:
With the common noun of mosquito are indicated the different species of insects "Dipteron Nematocera" of the family "Culex". They have a thin body which is long from 3 mm to 15 mm, provided with antennas and long and thin legs. The males feed on sugary substance of vegetable origin, while the she- mosquitos need a rich in proteins diet, so they resort to the "feed of blood" preferring as "blood donor" the human specie. Many species are annoying only for the stings, while many others, in addition to the irritation of their stings, can pass pathologies more or less dangerous. The anopheles pass the plasmodium of the malaria, the mosquitos of the genus "aedes" pass the virus of the yellow fever and of the "dengue", for example. The changed standards of living and of habitat make sure that, owing to the movings from a continent to the other, some species territorialize regions and countries where they have been always absent, being a danger for the spreading of new pathologies. The mosquito-tiger, always absent, made her appearence in Italy in 1990 and she is already present in Lombardia, Liguria, Lazio, Veneto. Few living organisms could adjust to the changes in the environment, taking advantage of the progressive pollution as the mosquitos have done. Sheet No. 2
In fact their grubs, which are able to live in polluted waters, aren't any more attacked by the fishes, great predator of grubs, which don't survive there for lack of oxygen. The mosquitos need some chemichal and physical stimuli, one for example is the carbon dioxide produced in abundance by the man and animals during the transpiration.
This permits to the mosquitos to recognize, even from an interval of several hundreds of meters, the possible prey. In the short distance olfactory signals, as those which rise from the sweat or from the urina, supply the mosquitos with the pecularities of the prey.
The corporal temperature and the transpiration indicate them the point of attack.
Reached the prey by this way, the mosquitos begin their "feed of blood".For sucking blood from the body of the preys, the mosquitos provide for drilling of the skin executed by a series of alternate movements of the two jaws, next to which the alimentary duct and the salivary duct, ipopharinx, are situated.
Inserted her proboscis in the skin of the host, the mosquito injects her saliva which causes a vasodilatation which determines a greater afflux of blood.
The saliva of the insect, besides to produce an allergic reaction, can insert in the organism of the prey patogenic agents.
As said we deduce that it is absolutely necessary to limit as greatly as possible the development of this insect by a full and differentiated struggle.
This struggle has to be carried out, responsibly by all the organisms which operate in the community, particularly by public and private body: the public body in defence and care of the public spaces, the citizens in the private spaces of own competence.
The struggle is carried out by mechanical and chemical action and by defences of natural origin.
Mechanical action by the removal of all those conditions which create suitable conditions for the development of the mosquitos. Sheet No. 3 Chemical action by insecticides aimed at the grown up insect or at grubs. By defences of natural origin, unguents, creams, various repellents in defence of the person, candles and others expedients to the essences of geranium, citronella etc like expedients in defence of the house. Aim of this invention is to obtain, by infusion, the enrichment of the liquids of the same infusions with substances of Inula Viscosa. These liquids, appropriately used, have carried out a significant and inhibitory action towards the olfactory system and the apparatus-sting of the mosquitos. Description of the invention:
The fnula Viscosa is a perennial plant of the family of the Composite, a little woody at the base and considerably branched. It is , in full, covered by a velum of grandular and microscopic hairs, which gives her the charatteristic stickiness. The leaves have lanceolate shape, dentate edges, and are sessile, stalkless. The yellow flowers are disposed in flower-head and form long and pyramidal clusters at the extremity of the stalk.
This plant, which was known in distant times for her antiseptic, antibacterial, hemostatic and cicatrizant properties, to day it is held in esteem for antimycotic properties of her substances. It is largely diffused in Italy, France, Spain, Turkey, Israel.
For the infusions, object of this invention, have been used parts of plant drawn in the area of Casteldaccia in province of Palermo.
Infusion n.l: 100 grams of vegetable oil in 50 leaves of Inula Viscosa, in erme tic pot for 48 h at room temperature. Infusion n.2: 100 grams of water in 50 leaves of Inula Viscosa, in ermetic pot for 48 h at room temperature. Irιfusionn.3: 100 grams of ethilic alcool in 50 leaves of Inula Viscosa, in ermetic pot for 48 h at room temperature. Sheet No.4
It is possible, further, to mix the infusions with all those substances existing on the market for the struggle against these insects.
The substances of Inula Viscosa have been analysed by the "Dipartimento di Chimica farmacologica della Universita di Palermo" with a Cromatografy of mass by the following strument:
MICROMASS AUTOSPEC-ULTLMA MAGNET
SYSTEM OF PUT-LN GAS CROMATOGRAFO
HEWLETT PACKARD HP 6890 Iniector splitless a 280°
Initial isotherm 120°C x 5 minutes
7 minute up to 280°
107minute up to 300°C isotherm of 10 minutes to 300° Colonna gas cromatografic: Atm -5-30mt-ID0,25mm-film thikness
0,25microm
The identification of the substances analysed has been done for comparison with library NIST-98 interfaced with the strument.
Substance 0 scanning line 210 12,36 2% gamma-gurjunene, 1,2,3 ,4,5,6,7- ocmaidro-l,4-dimethyl-7-(l-methylethenil)-azulene
Substance 1 scanning line 301 16,45 20% acid ilicic
Substance 2 scanning line 309 17,08 3% alcool at branched chain
Substance 3 scanning line 339 18,26 1,5% alcool at branched chain
Substance 4 scanning line 373 19,58 1% phitolo diterpene C20H40O Substance 5 scanning line 376 20,14 28% tomentosine C15H20O3 costituent oil specie Inula
Substance 6 scarming line 388-391 20,47 19% tayuina C15H20O3
Substance 7 scarining line 390-392 20.51 19% inuviscolide (4-hydrox-
10(14),1 l(13)-guaiadien-12,6-olide) Sheet No.5 Substance 8 scanning line 413-414 21,54 6% butilcitroso butyl ester of citric acid.

Claims

Sheet No.6 CLAIMS
1. Infusion of vegetable oil in Inula viscosa
2. Infusion of water in Inula Viscosa
3. usion of ethilic alcool in Inula Viscosa
4. Infusion of the claim 1 which owns properties against hematopfage insects
5. Infusion of the claim 2 which owns properties against hematophage insects
6. Infusion of the claim 3 which owns properties against hematophage insects
7. Infusion of the claim 4 to use against hematophage insects, mosquitos, flies and horseflies 8. Infusion of the claim 5 to use against hematophage insects, mosquitos, flies and horseflies 9. Infusion of the claim 6 to use against hematophage insects, mosquitos, flies and horseflies
PCT/IT2002/000550 2001-08-29 2002-08-27 Infusion of inula viscosa for controlling hematophagic insects, mosquitos, flies, and horseflies WO2003017768A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002334400A AU2002334400A1 (en) 2001-08-29 2002-08-27 Infusion of inula viscosa for controlling hematophagic insects, mosquitos, flies, and horseflies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2001A000513 2001-08-29
IT2001RM000513A ITRM20010513A1 (en) 2001-08-29 2001-08-29 INFUSION OF VISCOUS INULA HAVING PROPERTY AGAINST HEMATOPHAGIC INSECTS AND IN PARTICULAR AGAINST MOSQUITOES.

Publications (2)

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WO2003017768A2 true WO2003017768A2 (en) 2003-03-06
WO2003017768A3 WO2003017768A3 (en) 2003-09-25

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254112A (en) * 1978-05-31 1981-03-03 Laboratoire Debat Inula extract, its method of preparation and its use as pharmaceutical
US5837253A (en) * 1996-07-26 1998-11-17 Agrogene Ltd. Preparation and use of Inula extracts as a fungicide for the control of plant diseases
WO1999037316A1 (en) * 1998-01-23 1999-07-29 Safescience, Inc. Alkaline preparations of inula for the control of fungal diseases in plants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254112A (en) * 1978-05-31 1981-03-03 Laboratoire Debat Inula extract, its method of preparation and its use as pharmaceutical
US5837253A (en) * 1996-07-26 1998-11-17 Agrogene Ltd. Preparation and use of Inula extracts as a fungicide for the control of plant diseases
WO1999037316A1 (en) * 1998-01-23 1999-07-29 Safescience, Inc. Alkaline preparations of inula for the control of fungal diseases in plants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAOZ M ET AL: "ANTIMICROBIAL EFFECTS OF AQUEOUS PLANT EXTRACTS ON THE FUNGI MICROSPORUM CANIS AND TRICHOPHYTON RUBRUM AND ON THREE BACTERIAL SPECIES" LETTERS IN APPLIED MICROBIOLOGY, OXFORD, GB, vol. 26, January 1998 (1998-01), pages 61-63, XP002917741 *
MARZELL H: "W\RTERBUCH DER DEUTSCHEN PFLANZENNAMEN. BAND 2" 1972 , HIRZEL VERLAG , LEIPZIG XP002231485 171510 columns 1009-1011, entry Inula conyza column 1010, last paragraph -column 1011, paragraph 2 *

Also Published As

Publication number Publication date
WO2003017768A3 (en) 2003-09-25
ITRM20010513A1 (en) 2003-03-01
AU2002334400A1 (en) 2003-03-10
ITRM20010513A0 (en) 2001-08-29

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