WO2003015500A3 - Methods for the identification of inhibitors of phytochrome e expression or activity in plants - Google Patents

Methods for the identification of inhibitors of phytochrome e expression or activity in plants Download PDF

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Publication number
WO2003015500A3
WO2003015500A3 PCT/US2002/025919 US0225919W WO03015500A3 WO 2003015500 A3 WO2003015500 A3 WO 2003015500A3 US 0225919 W US0225919 W US 0225919W WO 03015500 A3 WO03015500 A3 WO 03015500A3
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WO
WIPO (PCT)
Prior art keywords
identification
methods
phytochrome
expression
activity
Prior art date
Application number
PCT/US2002/025919
Other languages
French (fr)
Other versions
WO2003015500A2 (en
Inventor
Neil Hoffman
Keith Davis
Adel Zayed
Robert Ascenzi
Douglas Boyes
Rao Mulpuri
Jorn Gorlach
Jeffrey Woessner
Carol Hamilton
Kenneth Phillips
Original Assignee
Paradigm Genetics Inc
Neil Hoffman
Keith Davis
Adel Zayed
Robert Ascenzi
Douglas Boyes
Rao Mulpuri
Jorn Gorlach
Jeffrey Woessner
Carol Hamilton
Kenneth Phillips
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paradigm Genetics Inc, Neil Hoffman, Keith Davis, Adel Zayed, Robert Ascenzi, Douglas Boyes, Rao Mulpuri, Jorn Gorlach, Jeffrey Woessner, Carol Hamilton, Kenneth Phillips filed Critical Paradigm Genetics Inc
Priority to AU2002355961A priority Critical patent/AU2002355961A1/en
Publication of WO2003015500A2 publication Critical patent/WO2003015500A2/en
Publication of WO2003015500A3 publication Critical patent/WO2003015500A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C12N15/8289—Male sterility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C12N15/829—Female sterility
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present inventors have discovered that the polypeptide phytochrome E, which is encoded by SEQ ID NO: 1, is essential for plant growth. Thus, the polypetide can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit the expression or activity of the polypeptide set forth in SEQ ID NO.2. Such compounds have use as herbicides. In addition, methods and compositions for modulating plant growth and development are provided.
PCT/US2002/025919 2001-08-15 2002-08-14 Methods for the identification of inhibitors of phytochrome e expression or activity in plants WO2003015500A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002355961A AU2002355961A1 (en) 2001-08-15 2002-08-14 Methods for the identification of inhibitors of phytochrome e expression or activity in plants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31248101P 2001-08-15 2001-08-15
US60/312,481 2001-08-15

Publications (2)

Publication Number Publication Date
WO2003015500A2 WO2003015500A2 (en) 2003-02-27
WO2003015500A3 true WO2003015500A3 (en) 2004-03-11

Family

ID=23211668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/025919 WO2003015500A2 (en) 2001-08-15 2002-08-14 Methods for the identification of inhibitors of phytochrome e expression or activity in plants

Country Status (2)

Country Link
AU (1) AU2002355961A1 (en)
WO (1) WO2003015500A2 (en)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CLACK ET AL.: "The phytochrome apoprotein family in arabidopsis is encoded by five genes: the sequences and expression of PHYD and PHYE", PLANT MOLECULAR BIOLOGY, vol. 25, no. 3, June 1994 (1994-06-01), pages 413 - 427, XP002931010 *
DATABASE GENBANK [online] August 1994 (1994-08-01), CLACK ET AL.: "A thaliana phyE gene", XP002965068, Database accession no. (X76610) *
DATABASE PROTEIN [online] January 1995 (1995-01-01), CLACK ET AL.: "Phytochrome E - arabidopsis thaliana", XP002965067, Database accession no. (S46313) *
DEVLIN ET AL.: "Phytochrome E influences internode elongation and flowering time in arabidopsis", THE PLANT CELL, vol. 10, no. 9, September 1998 (1998-09-01), pages 1479 - 1487, XP002965055 *
PALECANDA ET AL.: "Molecular and phenotypic specificity of an antisense PHYB gene in arabidopsis", PLANT MOLECULAR BIOLOGY, vol. 46, no. 1, May 2001 (2001-05-01), pages 89 - 97, XP002965054 *

Also Published As

Publication number Publication date
AU2002355961A1 (en) 2003-03-03
WO2003015500A2 (en) 2003-02-27

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